DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPR and GPR139

DIOPT Version :9

Sequence 1:NP_001368972.1 Gene:SPR / 31463 FlyBaseID:FBgn0029768 Length:512 Species:Drosophila melanogaster
Sequence 2:NP_001002911.1 Gene:GPR139 / 124274 HGNCID:19995 Length:353 Species:Homo sapiens


Alignment Length:362 Identity:86/362 - (23%)
Similarity:146/362 - (40%) Gaps:96/362 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 DNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSK---KSMATPTNFVLMGMAI 132
            ::::|:|:......|.: :|:..|.:  ||.:.:.:|.|.|::||:   :...:..|: |:.:|.
Human    11 NSSLSWWSPGSACGLGF-VPVVYYSL--LLCLGLPANILTVIILSQLVARRQKSSYNY-LLALAA 71

  Fly   133 CDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMP------------AMCHTISVWL 185
            .|:|.:.|        ..|         |...|...|.|..||            :..|| |:|:
Human    72 ADILVLFF--------IVF---------VDFLLEDFILNMQMPQVPDKIIEVLEFSSIHT-SIWI 118

  Fly   186 TLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWNGSPTEV 250
            |:.|.:.|||.|||.....|.....|.|:....:.:..||..:|.::          |       
Human   119 TVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYW----------W------- 166

  Fly   251 CHLETSMWVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQERRKLLFRENRK 315
                .::|..|||...:::...:: ....|:|:||.|...||.::...:     |||..||    
Human   167 ----PNIWTEDYISTSVHHVLIWI-HCFTVYLVPCSIFFILNSIIVYKL-----RRKSNFR---- 217

  Fly   316 KECKKLR--ETNCTTLMLIVVVSVFLLAEIPIAVVTAMHIVSSLIIEFLDYG-------LANICI 371
                 ||  .|..||.:|..:.|:|.....|..::...|:          ||       |.:|..
Human   218 -----LRGYSTGKTTAILFTITSIFATLWAPRIIMILYHL----------YGAPIQNRWLVHIMS 267

  Fly   372 MLTNFFLVFSYPINFGIYCGMSRQFR----ETFKEIF 404
            .:.|...:.:..|||.:||.:|::||    .|.|..|
Human   268 DIANMLALLNTAINFFLYCFISKRFRTMAAATLKAFF 304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPRNP_001368972.1 7tmA_FMRFamide_R-like 90..400 CDD:410630 80/337 (24%)
TM helix 1 92..116 CDD:410630 7/23 (30%)
TM helix 2 124..146 CDD:410630 6/21 (29%)
TM helix 3 169..191 CDD:410630 10/33 (30%)
TM helix 4 214..230 CDD:410630 2/15 (13%)
TM helix 5 270..293 CDD:410630 6/22 (27%)
TM helix 6 328..353 CDD:410630 5/24 (21%)
TM helix 7 368..393 CDD:410630 7/24 (29%)
GPR139NP_001002911.1 7tmA_GPR139 27..296 CDD:320585 80/336 (24%)
TM helix 1 29..53 CDD:320585 8/25 (32%)
TM helix 2 63..85 CDD:320585 8/39 (21%)
TM helix 3 102..124 CDD:320585 6/22 (27%)
TM helix 4 147..163 CDD:320585 2/15 (13%)
TM helix 5 181..204 CDD:320585 6/23 (26%)
TM helix 6 227..249 CDD:320585 5/21 (24%)
TM helix 7 264..289 CDD:320585 7/24 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157874
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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