DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPR and gpr142

DIOPT Version :9

Sequence 1:	NP_001368972.1	Gene:	SPR / 31463	FlyBaseID:	FBgn0029768	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	XP_001340684.2	Gene:	gpr142 / 100000501	ZFINID:	ZDB-GENE-130603-30	Length:	362	Species:	Danio rerio

Alignment Length:	425	Identity:	100/425 - (23%)
Similarity:	161/425 - (37%)	Gaps:	117/425 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 PCRMEDNNISYWNLTCDSPLEYAMPLYGYCMPFLLIITIISNSLIVLVLSKKSMATPTN-----F 125
            |.:.||...:.....|  .|.| :|:..|..  ||.:.:..|.|.::.|.:..:.|...     .
Zfish    10 PGQREDERSAQERSEC--VLAY-IPVVYYSA--LLCVGVPVNILTLVALYRLVVRTQKALYVYLL 69

  Fly   126 VLMGMAICDMLTVIFPAPGLWYMYTFGNHYKPLHPVSMCLAYSIFNEIMPAM-----------CH 179
            .|.|..|...|.:||                    |...|..::|:..:|.:           .:
Zfish    70 ALTGSDILSQLFIIF--------------------VGFLLETAVFHRDVPVLLLRSVSMMEFSAN 114

  Fly   180 TISVWLTLALAVQRYIYVCHAPMARTWCTMPRVRRCTAYIALLAFLHQLPRFFDRTYMPLVIEWN 244
            ..|:|.|:.|.|.||:.:||..:.|......|.||..|.:..||....:|.|           |.
Zfish   115 HASIWATVPLTVDRYVALCHPLLHRQISYPARARRIIAVVLTLALASGVPFF-----------WW 168

  Fly   245 GSPTEVCH----LETSM-WVHDYIGVDLYYTSYYLFRVLFVHLLPCIILVTLNILLFAAMRQAQE 304
            .....|.|    |:|:: |.|                |..::.|||.|.:.||.|:...:|:.|
Zfish   169 SDMWRVSHEPNNLDTALIWTH----------------VTIIYFLPCCIFLVLNSLIILRLRKRQ- 216

  Fly   305 RRKLLFRENRKKECKKLRETNCTTLMLIVVVSVFLLAEIPIAVVTAMHI-VSSLIIEF---LDYG 365
             |:.:.::...::.........||.||:.|.|||.:...|...|...|: |:|:..::   |.|.
Zfish   217 -RQQMCQDESGQQLAVPSRLGKTTAMLLAVTSVFAVLWAPRTGVVLYHLYVTSVHNDWRVHLAYD 280

  Fly   366 LANICIMLTNFFLVFSYPINFGIYCGMSRQFRETFKEIFLGRLMAKKDSSTKYSIVNGARTCTNT 430
            |||:..||..       .:||.:||.:|:.||...:::.|.|               ||
Zfish   281 LANMLAMLNT-------AVNFFLYCFVSKPFRAAVRDVLLFR---------------GA------ 317

  Fly   431 NETVLXXLVMLVPRRGSSDHRR-SSTSTTTTTTTK 464
                     .|.|||...:.|. ::.||::.::||
Zfish   318 ---------PLHPRRPLRNQRTPANASTSSISSTK 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPR	NP_001368972.1	7tmA_FMRFamide_R-like	90..400	CDD:410630	81/334 (24%)
		TM helix 1	92..116	CDD:410630	6/23 (26%)
		TM helix 2	124..146	CDD:410630	6/26 (23%)
		TM helix 3	169..191	CDD:410630	6/32 (19%)
		TM helix 4	214..230	CDD:410630	4/15 (27%)
		TM helix 5	270..293	CDD:410630	6/22 (27%)
		TM helix 6	328..353	CDD:410630	9/24 (38%)
		TM helix 7	368..393	CDD:410630	7/24 (29%)
gpr142	XP_001340684.2	7tm_4	40..315	CDD:304433	78/330 (24%)
gpr142	XP_001340684.2	7tm_1	46..297	CDD:278431	72/306 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593678
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421120at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940