| Sequence 1: | NP_002119.1 | Gene: | HMGB1 / 3146 | HGNCID: | 4983 | Length: | 215 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001260269.1 | Gene: | SoxN / 44275 | FlyBaseID: | FBgn0029123 | Length: | 761 | Species: | Drosophila melanogaster |
| Alignment Length: | 122 | Identity: | 26/122 - (21%) |
|---|---|---|---|
| Similarity: | 44/122 - (36%) | Gaps: | 32/122 - (26%) |
- Green bases have known domain annotations that are detailed below.
|
Human 396 VSSSTGGQYRCYGAHNLSSEW-SASSEPLDILITGQLPLTPSLSVKPNHTVHSG------ETVSL 453
Human 454 LCWSMDPVDTFILSKEG-----SAQQPLRL--------KSKSHDQQSQAEFSMSAVT 497 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HMGB1 | NP_002119.1 | Sufficient for interaction with HAVCR2. /evidence=ECO:0000250|UniProtKB:P63158 | 1..97 | ||
| LPS binding (delipidated). /evidence=ECO:0000269|PubMed:21660935 | 3..15 | ||||
| HMG-box_HMGB_rpt1 | 8..76 | CDD:438794 | |||
| Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159 | 27..43 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 76..95 | ||||
| LPS binding (Lipid A). /evidence=ECO:0000269|PubMed:21660935 | 80..96 | ||||
| Cytokine-stimulating activity. /evidence=ECO:0000269|PubMed:12765338 | 89..108 | ||||
| HMG-box_HMGB_rpt2 | 93..163 | CDD:438795 | |||
| Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159 | 150..183 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 161..215 | ||||
| Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159 | 178..184 | ||||
| SoxN | NP_001260269.1 | HMG-box_SoxB | 177..252 | CDD:438790 | |
| Blue background indicates that the domain is not in the aligned region. | |||||