Protein Alignment HMGB1 and Sox14

DIOPT Version :10

• Sequence 1: NP_002119.1
• Gene: HMGB1 / 3146
• HGNCID: 4983
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_476894.1
• Gene: Sox14 / 37822
• FlyBaseID: FBgn0005612
• Length: 669
• Species: Drosophila melanogaster
• Alignment Length: 117
• Identity: 35/117 - (29%)
• Similarity: 56/117 - (47%)
• Gaps: 5/117 - (4%)

Human    80 PPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPY 144
            |....|:.|...|...|||.:||.::....|.||....|.|...:::|:||..|...:.||||||
  Fly   172 PYSDATRTKKHSPGHIKRPMNAFMVWSQMERRKICERTPDLHNAEISKELGRRWQLLSKDDKQPY 236

Human   145 EKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEED 196
            ..:|.||::.:..:...|  |.:|   :|...::..|.|..::.:..|...|
  Fly   237 IIEAEKLRKLHMIEYPNY--KYRP---QKKQTRSPGSLKPNQDADGCEARND 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGB1	NP_002119.1	Sufficient for interaction with HAVCR2. /evidence=ECO:0000250|UniProtKB:P63158	1..97		4/16 (25%)
		LPS binding (delipidated). /evidence=ECO:0000269|PubMed:21660935	3..15
		HMG-box_HMGB_rpt1	8..76	CDD:438794
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159	27..43
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..95		4/14 (29%)
		LPS binding (Lipid A). /evidence=ECO:0000269|PubMed:21660935	80..96		4/15 (27%)
		Cytokine-stimulating activity. /evidence=ECO:0000269|PubMed:12765338	89..108		6/18 (33%)
		HMG-box_HMGB_rpt2	93..163	CDD:438795	23/69 (33%)
		Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159	150..183		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..215		8/36 (22%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159	178..184		1/5 (20%)
Sox14	NP_476894.1	HMG-box_SoxC	186..261	CDD:438838	26/79 (33%)