DRSC/TRiP Functional Genomics Resources

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Protein Alignment HMGB1 and Hmg-2

DIOPT Version :10

Sequence 1:NP_002119.1 Gene:HMGB1 / 3146 HGNCID:4983 Length:215 Species:Homo sapiens
Sequence 2:NP_611553.1 Gene:Hmg-2 / 37407 FlyBaseID:FBgn0026582 Length:376 Species:Drosophila melanogaster


Alignment Length:207 Identity:49/207 - (23%)
Similarity:90/207 - (43%) Gaps:28/207 - (13%)


- Green bases have known domain annotations that are detailed below.


Human    26 EHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKG------- 83
            |...|.||| |..|..|...:.:     :.:....||..:...|:.:::.|.   |||       
  Fly     3 EPTSKTPDA-VPESPVSLPIASQ-----SMDTATIEDFDEDKPAKGKKKAKN---PKGRHSDSDI 58

Human    84 --ETKK----KFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQ 142
              |.||    :.....|||.|.:.:..|.::.|.:::.|.|..:..:..:.:||.|:....:.|.
  Fly    59 GSELKKLAQRRINVAGAPKMPLNGYVRFMNDRREELRREQPQRTALEHTRIIGEEWHQLPEERKL 123

Human   143 PYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKK-----KKEEEEDEEDEEDEEEEED 202
            ||.:.|||.|..|::.:..: .|..|:.....:.||:|:.|     |::..:.|......::.:.
  Fly   124 PYIEAAAKDKAIYQEQLQMF-LKEHPEIVANELAKAKKATKLDGSPKEKTPKGESALGKAKKTKA 187

Human   203 EEDEDEEEDDDD 214
            :..:.:.||.||
  Fly   188 KPVKRQSEDPDD 199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HMGB1NP_002119.1 Sufficient for interaction with HAVCR2. /evidence=ECO:0000250|UniProtKB:P63158 1..97 20/83 (24%)
LPS binding (delipidated). /evidence=ECO:0000269|PubMed:21660935 3..15
HMG-box_HMGB_rpt1 8..76 CDD:438794 11/49 (22%)
Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159 27..43 6/15 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 76..95 7/31 (23%)
LPS binding (Lipid A). /evidence=ECO:0000269|PubMed:21660935 80..96 7/28 (25%)
Cytokine-stimulating activity. /evidence=ECO:0000269|PubMed:12765338 89..108 5/18 (28%)
HMG-box_HMGB_rpt2 93..163 CDD:438795 19/69 (28%)
Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159 150..183 8/32 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 161..215 12/59 (20%)
Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159 178..184 3/10 (30%)
Hmg-2NP_611553.1 HMG-box_HMG20 75..154 CDD:438796 21/79 (27%)
Blue background indicates that the domain is not in the aligned region.

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