Protein Alignment HMGB1 and Dsp1

DIOPT Version :10

• Sequence 1: NP_002119.1
• Gene: HMGB1 / 3146
• HGNCID: 4983
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_001138203.1
• Gene: Dsp1 / 117294
• FlyBaseID: FBgn0278608
• Length: 397
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 98/214 - (45%)
• Similarity: 146/214 - (68%)
• Gaps: 6/214 - (2%)

Human     8 KPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYE 72
            ||||:|::||:|||||||||||||||.:|.|:|||:||:||||||..|||.:|.:||:.||.|||
  Fly   182 KPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYE 246

Human    73 REMKTYIPPK------GETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGE 131
            .||:.|:|||      |:.:|:.||||||||..||||.||::.|.|:|..:|...:||:||:||.
  Fly   247 AEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGR 311

Human   132 MWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEED 196
            .|::...:.||.||..|.:.|.:||:::..|:..||...:...:..:.:::.:|........::.
  Fly   312 KWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQASMQAQAQKAALLAAAAQQQ 376

Human   197 EEEEEDEEDEDEEEDDDDE 215
            .::.|::.|:|:.:.||||
  Fly   377 HQQLEEQHDDDDGDGDDDE 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HMGB1	NP_002119.1	Sufficient for interaction with HAVCR2. /evidence=ECO:0000250|UniProtKB:P63158	1..97		60/94 (64%)
		LPS binding (delipidated). /evidence=ECO:0000269|PubMed:21660935	3..15		5/6 (83%)
		HMG-box_HMGB_rpt1	8..76	CDD:438794	47/67 (70%)
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159	27..43		11/15 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..95		10/24 (42%)
		LPS binding (Lipid A). /evidence=ECO:0000269|PubMed:21660935	80..96		10/21 (48%)
		Cytokine-stimulating activity. /evidence=ECO:0000269|PubMed:12765338	89..108		14/18 (78%)
		HMG-box_HMGB_rpt2	93..163	CDD:438795	30/69 (43%)
		Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159	150..183		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..215		9/53 (17%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159	178..184		0/5 (0%)
Dsp1	NP_001138203.1	HMG-box_HMGB_rpt1	182..250	CDD:438794	47/67 (70%)
		HMG-box_NHP6-like	262..342	CDD:438792	35/79 (44%)