DRSC/TRiP Functional Genomics Resources

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Protein Alignment spoon and AKAP1

DIOPT Version :10

Sequence 1:NP_726992.2 Gene:spoon / 31459 FlyBaseID:FBgn0263987 Length:607 Species:Drosophila melanogaster
Sequence 2:NP_003479.1 Gene:AKAP1 / 8165 HGNCID:367 Length:903 Species:Homo sapiens


Alignment Length:587 Identity:151/587 - (25%)
Similarity:265/587 - (45%) Gaps:86/587 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 SSAINDSS--IEPTVQARKANGVLQNGKLPQQSASKSMNINGTLVNGSGSGSGSSSDEKDSPTTM 124
            |..|::::  :..|...:.|..|.|..:|..|.....:.::...|.|..:...::::...:|...
Human   353 SQVISEATEQVLATTVGKVAGRVCQASQLQGQKEESCVPVHQKTVLGPDTAEPATAEAAVAPPDA 417

  Fly   125 LYGKSAPIKIQSNGRTSNGKHQQQIDSEILKSKIQ----------DAEHKTLCSIDEDFENLSSP 179
              |...|      |..:.|....:.....|||.:.          .|.|.:|.|.    ..|::|
Human   418 --GLPLP------GLPAEGSPPPKTYVSCLKSLLSSPTKDSKPNISAHHISLASC----LALTTP 470

  Fly   180 -RDLPDSVNTRVSFYNRKATQKTVEPVVIKATRTPKISPENSFLDTNYTNKECEQNNNCEPKEEP 243
             .:|||    |.......||  .|..:...:...|.::......|:..|:   ...::|   .|.
Human   471 SEELPD----RAGILVEDAT--CVTCMSDSSQSVPLVASPGHCSDSFSTS---GLEDSC---TET 523

  Fly   244 SKKEADQEELEQDQEQT------VLKEEVVD---------------SNGNQKRNVDAASPSLSIC 287
            |....|:.......|.|      |||.|:.|               |.|:.:.::|:.....|:.
Human   524 SSSPRDKAITPPLPESTVPFSNGVLKGELSDLGAEDGWTMDAEADHSGGSDRNSMDSVDSCCSLK 588

  Fly   288 SVQSGDSGKGSSLPRSEATRVKTTYEFLFPISLIGHLYGRKRAFINQIKAKTLASVSVGKNPYSG 352
            ..:|..:.:..|.|:.....:   :|...|..|:|.|.|::..:::.:|..:.|.:.:...||:.
Human   589 KTESFQNAQAGSNPKKVDLII---WEIEVPKHLVGRLIGKQGRYVSFLKQTSGAKIYISTLPYTQ 650

  Fly   353 KVRICTIEGTESEIDAALAMIRQRLPAKRYPNFTMQRIH------FALPQTIVPLSTESLYNLQL 411
            .|:||.|||::..:|.||.:|     .|::....:..|:      .|||.  :|:::      .|
Human   651 SVQICHIEGSQHHVDKALNLI-----GKKFKELNLTNIYAPPLPSLALPS--LPMTS------WL 702

  Fly   412 KLIEGINNDVVVSAVLSGSHIFIQHPLHPSHPSLPLLQKQLYDSYSTMEAPLLPS-LELSAVCVI 475
            .|.:||..:|:|...::..|:|:|...||:..:|..|.:|:|..||....|.||: :|::.:|..
Human   703 MLPDGITVEVIVVNQVNAGHLFVQQHTHPTFHALRSLDQQMYLCYSQPGIPTLPTPVEITVICAA 767

  Fly   476 PIND-VWYRVQIVDTDPEDEERCVIKFLDFGGYMNVGFNTLRQIRTDFMNVPFQSTECILSNIEP 539
            |..| .|:|.|:|.:..|..| ..|:::|:|||..|..:.|||||:||:.:|||..|.:|.::.|
Human   768 PGADGAWWRAQVVASYEETNE-VEIRYVDYGGYKRVKVDVLRQIRSDFVTLPFQGAEVLLDSVMP 831

  Fly   540 IG--GTWSIEAAEILNKLTKGIVLQAQVAGYNSHNLPEIFLFASLGPNNVIFINKELVGRKLAKW 602
            :.  ..:|.||...::::|....|.|||..|:...||.|.|::.:| :.|:.||:.||.|.||:|
Human   832 LSDDDQFSPEADAAMSEMTGNTALLAQVTSYSPTGLPLIQLWSVVG-DEVVLINRSLVERGLAQW 895

  Fly   603 VE 604
            |:
Human   896 VD 897

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spoonNP_726992.2 KH-I 311..378 CDD:469614 20/66 (30%)
Tudor_AKAP1 463..539 CDD:410478 30/77 (39%)
AKAP1NP_003479.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..128
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 175..210
PRK00106 181..>380 CDD:178867 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..260
RNase_Y_N <307..>368 CDD:463456 3/14 (21%)
protein kinase Atethering region: binding RII subunits of protein kinase A 331..389 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 513..544 7/36 (19%)
KH-I_AKAP1 609..676 CDD:411823 21/74 (28%)
Tudor_AKAP1 755..831 CDD:410478 30/76 (39%)
Blue background indicates that the domain is not in the aligned region.

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