DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spoon and akap1b

DIOPT Version :9

Sequence 1:	NP_726992.2	Gene:	spoon / 31459	FlyBaseID:	FBgn0263987	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001091649.2	Gene:	akap1b / 556208	ZFINID:	ZDB-GENE-030131-6844	Length:	837	Species:	Danio rerio

Alignment Length:	577	Identity:	148/577 - (25%)
Similarity:	269/577 - (46%)	Gaps:	104/577 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SSAINDSSIEPTVQARKANGVLQNGKLPQQSASKSMNINGTLVNG---------------SGSGS 111
            |.|.:||::       ..||..::.:||:.:.|::..|...:|||               .|..|
Zfish   329 SEASDDSTL-------ALNGKEESSQLPKSAESRAAQIAEEIVNGCLAPSLWKMPENEKDRGLLS 386

  Fly   112 GSSSDEKDSPTTMLYGKSAPIKIQSNG----RTSNGKHQQQIDSEILKSKIQDAEHKTLCSIDED 172
            ..|.::.:|..|:...::....::.:|    ::.:|...:.:.|..|.|.:.:::        ||
Zfish   387 VPSGEQLESTPTLAKLQAEEALVEDSGCSTCQSEDGVSSEDLHSTGLSSTVSESK--------ED 443

  Fly   173 FENLSSPRDLPDSVNTRVSFYNRKATQ----KTVEPVVIKATRTPKISPENSFLDTNYTNKECEQ 233
            ...:|.               ..|||:    :..|.:.:       |:|:.|.|........||.
Zfish   444 LIQISG---------------TCKATEGQEDRLHESLAL-------IAPQESPLTAENVATVCEA 486

  Fly   234 ---NNNCEPKEEPSKKEADQEELEQDQEQTVLKEEVVDSNGNQKRNVDAASPSLSICSVQSGDSG 295
               |.........|:.:|||                  |.|:...::|    |:..||......|
Zfish   487 ARLNGTGLRNGAASEVDADQ------------------SGGSDVNSMD----SVDSCSTLGAGDG 529

  Fly   296 K--GSSLPRSEATRVKTTYEFLFPISLIGHLYGRKRAFINQIKAKTLASVSVGKNPYSGKVRICT 358
            :  .|...:|:::.: ..:|...|..|:|.|.|::..:::.:|..:.|.:.:...||:.:.:||.
Zfish   530 QLSASQTCQSQSSEL-IVWEIEVPKHLVGRLIGKQGRYVSFLKQSSGAKIYISTLPYTQEFQICH 593

  Fly   359 IEGTESEIDAALAMIRQRLPAKRYPNFTMQRIHFALPQTIVPLSTESL-YNLQLKLIEGINNDVV 422
            ||||:.::|.|||:|     .|::.:..:..::...|.   ||:..|| ....|.|..|:..:|:
Zfish   594 IEGTQQQVDKALALI-----GKKFKDLDLTNLYAPPPP---PLTLPSLPMTSWLLLPSGVTVEVI 650

  Fly   423 VSAVLSGSHIFIQHPLHPSHPSLPLLQKQLYDSYSTMEAPLLPS-LELSAVCVIP-INDVWYRVQ 485
            |..::|..|:|:|...||::.:|..|.:|::..||....|.||| :|:..:|..| ::..|:|.|
Zfish   651 VVNIVSAGHVFVQQHTHPTYHALRSLDQQMFLCYSQPGTPPLPSPVEVGVICAAPAVDGAWWRAQ 715

  Fly   486 IVDTDPEDEERCVIKFLDFGGYMNVGFNTLRQIRTDFMNVPFQSTECILSNIEPIGG--TWSIEA 548
            :: :..:|.....|:::|:|||..|..:||||||:||:.:|||.||.:|.||.|:.|  .:|.||
Zfish   716 VI-SFYKDSTEVEIRYVDYGGYDRVKIDTLRQIRSDFVTLPFQGTEVLLDNIAPLPGEDRFSAEA 779

  Fly   549 AEILNKLTKGIVLQAQVAGY-NSHNLPEIFLFASLGPNNVIFINKELVGRKLAKWVE 604
            ...|.::|:|:.|.|||..| |:..||.:.::..:| ..::.:|:.|..|....||:
Zfish   780 NSALEEMTRGVPLLAQVTNYDNNTGLPLVHMWNMVG-EELVLLNRTLAERGFGTWVD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spoon	NP_726992.2	KH-I	311..373	CDD:238053	20/61 (33%)
		TUDOR	413..536	CDD:278965	46/124 (37%)
		TUDOR	465..522	CDD:295375	21/58 (36%)
akap1b	NP_001091649.2	KH-I	548..608	CDD:238053	20/59 (34%)
		TUDOR	641..765	CDD:278965	46/124 (37%)
		TUDOR	694..751	CDD:197660	20/57 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595320
Domainoid	1	1.000	93	1.000	Domainoid score	I7508
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4068
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006304
OrthoInspector	1	1.000	-	-		otm24206
orthoMCL	1	0.900	-	-		OOG6_107934
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2941
SonicParanoid	1	1.000	-	-		X4588
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.920