DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spoon and akap-1

DIOPT Version :9

Sequence 1:	NP_726992.2	Gene:	spoon / 31459	FlyBaseID:	FBgn0263987	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001370528.1	Gene:	akap-1 / 175898	WormBaseID:	WBGene00016977	Length:	867	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	175/766 - (22%)
Similarity:	292/766 - (38%)	Gaps:	234/766 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RCCCCSG-------KVTIFQYSAKMVSGRPLLYLSLPGVAFILGVFWFRRRYKNCLDKPDDEDSS 63
            ||...|.       .:.:.|.|:  |:.:..|.::|.|.:......|:       ::|.|.:..
Worm    81 RCLLFSSIFFAIDPSLALAQMSS--VASKHALLIALGGFSIAALFVWY-------INKKDKDGR- 135

  Fly    64 AINDSSIEPTVQARKANGVLQNGKLPQQSASKSMNINGTL--VNGSGSGSGSSS----------- 115
                       :.:|...|:.||.....:||.....||.:  .||..:|...||
Worm   136 -----------KKKKVGDVISNGLPKTATASDVQTENGNVKKANGHVNGDVQSSIGVSQKQQQKD 189

  Fly   116 -DEK---------------------DSPTTMLYGKSAPIKIQSNGRTSNGKHQQQIDSEILKSKI 158
             |||                     .:||.....|:..|..:    |....|....||.:: |:.
Worm   190 EDEKTQKKDAVQNEKPSIDKKQPKSQAPTEKKEEKTVEIHTE----TEETDHVAAGDSGVV-SEH 249

  Fly   159 QDAEHKTL------CSIDEDFENLSSPRDLPDSVNTRVSFYNRKATQKTVEPVV----------- 206
            ::.:.||.      .|||:..|.:..|:        :....|.:..:::.|.||
Worm   250 KEHDKKTKQKNDEPVSIDKKSEEIEVPK--------QAGVVNEEPKKQSEETVVEEQFVKKEEPK 306

  Fly   207 IKATRTP--------------------------------------KISP---------ENSFLDT 224
            :|:..||                                      ::||         |.||.:.
Worm   307 LKSAPTPLLTMPSKKKVLENEQIPEEPTPTKMNDATSPLSLDIAAQMSPASFSWSEEMEKSFNEE 371

  Fly   225 NYTNKEC-----------------------------------------EQNNNCEPKEEP----- 243
            .:...|.                                         :|.:..:.|||.
Worm   372 EFRLNESSDIDRSPASPLRHLQQQHNKNRSSQKRKGGRVNGRDGVHQPQQQHQQQKKEEQGQIKK 436

  Fly   244 -----SKKEADQEELEQDQEQTVLKE-----------EVVDSNGNQKRNVDAA-SPSLSI--CSV 289
                 :|:::.:|..|:.|::.|||.           ::::|..::..:.:.: ||.|..  ...
Worm   437 GQRRLTKEKSVEETPEKSQKRVVLKHHENEAGDAAHAQIIESPHHENASYEKSDSPGLDSQNSEA 501

  Fly   290 QSGDSGKGSSLPRSEATRVKTT-------YEFLFPISLIGHLYGRKRAFINQIKAKTLASVSVGK 347
            .|.|||:.:....|......||       |||..|.||:|.:.|.|...|.::..:|...:.:.:
Worm   502 SSQDSGRATGPLASPHEDGLTTEDDFLPMYEFEIPNSLVGLIIGVKGKTIKELSVRTNVRMLIRQ 566

  Fly   348 NPYSGKVR---ICTIEGTESEIDAALAMIRQRLPAKRYPNFTMQRIHFALPQTIVPLSTESLYNL 409
            :..:.||:   ||.:.|...||:..|.|:|:|.|..|:|...:|.:   :| .::|.|...:.:.
Worm   567 HHETDKVKTHQICQVRGKRDEINHCLQMLRRRFPPARFPELNLQPV---VP-PVLPNSNFDMLST 627

  Fly   410 Q---LKLIEGINNDVVVSAVLSGSHIFIQHPLHPSHPSLPLLQKQLYDSYSTMEAPLLPSLEL-- 469
            |   |.|.|.|..:|.||:::|.||.|||.|.|||..||..|...:...|.  |...||.|.:
Worm   628 QPTWLTLPEDIKCEVAVSSIISASHFFIQQPTHPSFASLRHLDMYMGSLYG--EQSNLPELPIPC 690

  Fly   470 --SAVCVIPINDVWYRVQIVDTDPEDEERCVIKFLDFGGYMNVGFNTLRQIRTDFMNVPFQSTEC 532
              ..:|..|:.:.|:|...|....|.:| ..:||:|:|||..:....|||||||.|::||||||.
Worm   691 QNGLLCAAPVGNAWFRAVTVQYFDETDE-VFVKFVDYGGYSKMARQDLRQIRTDLMSLPFQSTEV 754

  Fly   533 ILSNIEPIGGT--WSIEAAEILNKLTKGIVLQAQVAGYNSHN--LPEIFLF 579
            :|:::.|:.||  ||..|.:....:..|.|:..::.| .||:  :|.:.|:
Worm   755 MLAHVRPVDGTTNWSDAAMQKFRAMCIGKVINCKMVG-QSHDTRIPMVELY 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spoon	NP_726992.2	KH-I	311..373	CDD:238053	20/71 (28%)
		TUDOR	413..536	CDD:278965	52/126 (41%)
		TUDOR	465..522	CDD:295375	21/60 (35%)
akap-1	NP_001370528.1	pneumo_PspA	181..>328	CDD:411490	26/159 (16%)
		PTZ00121	<183..>477	CDD:173412	43/306 (14%)
		KH-I_AKAP1	530..600	CDD:411823	22/69 (32%)
		Tudor_AKAP1	686..761	CDD:410478	29/75 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166778
Domainoid	1	1.000	91	1.000	Domainoid score	I4907
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7503
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006304
OrthoInspector	1	1.000	-	-		oto20244
orthoMCL	1	0.900	-	-		OOG6_107934
Panther	1	1.100	-	-	LDO	PTHR22948
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2941
SonicParanoid	1	1.000	-	-		X4588
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.820