Protein Alignment Usp16-45 and USP3

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_006528.2
• Gene: USP3 / 9960
• HGNCID: 12626
• Length: 520
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 110/483 - (22%)
• Similarity: 174/483 - (36%)
• Gaps: 157/483 - (32%)

  Fly    88 ASEGAVGPGGNPVTF-----EFDNTLWLCLKCGSQLCGRARHKHALEHYQ------TPHSDS--- 138
            |.:.|..|.|:|.::     ..:.:.|:||.|.|..|||..:.||.:||:      |.|..|
Human    13 APDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQ 77

  Fly   139 ----HALAMNTRSFDIWCYECDMKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEK 199
                |.:.|:..|:..:||.||..:.::.:..|   |:.|::..|....|..|..       ..|
Human    78 DKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGL---VQKVREHLQNLENSAFTAD-------RHK 132

  Fly   200 LKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLT 264
            .:..||:                               |:.|.::            |..:.|.|
Human   133 KRKLLEN-------------------------------STLNSKL------------LKVNGSTT 154

  Fly   265 SVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPF 329
            ::          .||                           ||.|||||||.||::|.|:....
Human   155 AI----------CAT---------------------------GLRNLGNTCFMNAILQSLSNIEQ 182

  Fly   330 LLSVLKELSEPGEEFILPGG------TFTIKDKGDIELPMI----KGTLSSWGGLTAALANALEE 384
            .....|||  |..|  |..|      |:..:.:||..:.::    |...:.|.|...|
Human   183 FCCYFKEL--PAVE--LRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTA------- 236

  Fly   385 LQAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQD 449
                   |:|..||..:....|.|.|..|.||||.:|.||:.:..|         ||. |:....
Human   237 -------FSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLE---------LQG-GFNGVS 284

  Fly   450 VNSVSEE-----MRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPV 509
            .:::.:|     ...||.|.|   ...::  ..:|.|.|.:.:.|..|...|.:.:.|||:||.:
Human   285 RSAILQENSTLSASNKCCING---ASTVV--TAIFGGILQNEVNCLICGTESRKFDPFLDLSLDI 344

  Fly   510 AVE-KPQPPQRRKPSPELSLTSSSSSVT 536
            ..: :.:..:.::..|..||.....|.|
Human   345 PSQFRSKRSKNQENGPVCSLRDCLRSFT 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	22/63 (35%)
		UBP12	<307..990	CDD:227847	67/246 (27%)
		Peptidase_C19	307..>512	CDD:470612	62/219 (28%)
		Peptidase_C19K	<849..1123	CDD:239132
USP3	NP_006528.2	zf-UBP	29..105	CDD:460464	22/75 (29%)
		UCH	159..508	CDD:425685	68/274 (25%)