Protein Alignment Usp16-45 and USP15

DIOPT Version :9

• Sequence 1: NP_001284890.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001239007.1
• Gene: USP15 / 9958
• HGNCID: 12613
• Length: 981
• Species: Homo sapiens
• Alignment Length: 1080
• Identity: 223/1080 - (20%)
• Similarity: 351/1080 - (32%)
• Gaps: 387/1080 - (35%)

  Fly   153 YECDMKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGS 217
            |..::|:|.|...|     .:|.:...|         ..||..||::::....     :|
Human   132 YLTELKLCENGNMN-----NVVTRRFSK---------ADTIDTIEKEIRKIFS-----IP----- 172

  Fly   218 FDDSSSR-----------------GSLAAAG---GGGGVGSSRNRQVAIPMPPPEPSS-GLSTSD 261
             |:..:|                 .::..||   |...|...:|.....|..|..|.| |.|...
Human   173 -DEKETRLWNKYMSNTFEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPGASNFS 236

  Fly   262 SLTSVPGMAKRIDQYSATTNGNTGNK----------RLLTLETPRIENERLPRVRGLTNLGNTCF 316
            :|..: ..:...:.|:...|.|..|.          :......|...||: |.:.||:|||||||
Human   237 TLPKI-SPSSLSNNYNNMNNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQ-PGLCGLSNLGNTCF 299

  Fly   317 FNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANA 381
            .|:.:|||:.||           |..|:.|       .||...|| .....|...|.:..:.|..
Human   300 MNSAIQCLSNTP-----------PLTEYFL-------NDKYQEEL-NFDNPLGMRGEIAKSYAEL 345

  Fly   382 LEELQAGG-SVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGY 445
            ::::.:|. |..|||....::....|||:|..|.|..|||..||:.: :|||.|.::.....|
Human   346 IKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGL-HEDLNRIRKKPYIQL-- 407

  Fly   446 KDQDVNSVSEEMRQKCKIYGNQAGDRILRPE-----QVFRGFLVSTLTCQDCHNVSSRHEYFLDM 505
            ||.|        .:..|:...:|.:..|:..     .:|.|...|||.|.:|..:|...:.|..:
Human   408 KDAD--------GRPDKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYL 464

  Fly   506 SLPVAVEK--------------PQPPQRRKPSPEL-SLTSSSSSVTPSTGQPTINTKFTDGSVNF 555
            :||:.::|              .:|.|.:...|:: ::....::::..:|.|......||
Human   465 TLPLPMKKERTLEVYLVRMDPLTKPMQYKVVVPKIGNILDLCTALSALSGIPADKMIVTD----- 524

  Fly   556 TASSPSFFLHA-HEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVD 619
                  .:.|. |...::..:.|.:                                      ::
Human   525 ------IYNHRFHRIFAMDENLSSI--------------------------------------ME 545

  Fly   620 QDDASLASLGAGDGQANDGLEQTNGQTEDS-------------TTSSVTTSEHSDA--------- 662
            :||..:             .|....:|||:             ..||.|  .|:.:
Human   546 RDDIYV-------------FEININRTEDTEHVIIPVCLREKFRHSSYT--HHTGSSLFGQPFLM 595

  Fly   663 -----DVEDNLVEDTAAPSTNNVPSSTASLTAPSKTY----MDSNGNAQPPGEKRDDTPEHMDKD 718
                 :.||.|...........|..||.:.......:    .:.|||. |.|...:.:|..|:.|
Human   596 AVPRNNTEDKLYNLLLLRMCRYVKISTETEETEGSLHCCKDQNINGNG-PNGIHEEGSPSEMETD 659

  Fly   719 SLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKG 783
              |.|:..|.....|:.. .||.:..|..|:|:|..|.       ..||..            ||
Human   660 --EPDDESSQDQELPSEN-ENSQSEDSVGGDNDSENGL-------CTEDTC------------KG 702

  Fly   784 ASVIRQVSVGAEQGASNGTEDAD---GEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSY--SDW 843
            .....:..:...|..:.|..|.:   .:.:.|...:              |..|:..:|:  .||
Human   703 QLTGHKKRLFTFQFNNLGNTDINYIKDDTRHIRFDD--------------RQLRLDERSFLALDW 753

  Fly   844 STTIAPRY----QCEDGE--------------CSVQSCLNNFTAVELMTGQNKVGCDSCTQRING 890
            ...:..||    ..||.|              ..::.|:..||..|.:..::...|.:|.:
Human   754 DPDLKKRYFDENAAEDFEKHESVEYKPPKKPFVKLKDCIELFTTKEKLGAEDPWYCPNCKE---- 814

  Fly   891 SDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYP-NLLDIAAFCGSKVK 954
                    :..|||:|.:.|.|.||::|||||... |.:..||...|.:| |.||::.|.
Human   815 --------HQQATKKLDLWSLPPVLVVHLKRFSYS-RYMRDKLDTLVDFPINDLDMSEFL----- 865

  Fly   955 NLPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQ 1019
                |:.......|.|..|..|.|||.||||||:.|                       ::||
Human   866 ----INPNAGPCRYNLIAVSNHYGGMGGGHYTAFAK-----------------------NKDD-- 901

  Fly  1020 LKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLE 1084
                                                                             
Human   902 ----------------------------------------------------------------- 901

  Fly  1085 EAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                     |||||..||.|...|||..:...||:|||:|
Human   902 ---------GKWYYFDDSSVSTASEDQIVSKAAYVLFYQR 932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	1/5 (20%)
		Peptidase_C19	307..>512	CDD:271592	63/210 (30%)
		Peptidase_C19K	<849..1123	CDD:239132	65/292 (22%)
USP15	NP_001239007.1	Mediates interaction with SART3. /evidence=ECO:0000269|PubMed:24526689	2..223		20/115 (17%)
		UBP12	12..932	CDD:227847	222/1078 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	216..237		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	629..694		18/68 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	952..981

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900