DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and USP6

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_001291213.1	Gene:	USP6 / 9098	HGNCID:	12629	Length:	1406	Species:	Homo sapiens

Alignment Length:	1314	Identity:	262/1314 - (19%)
Similarity:	413/1314 - (31%)	Gaps:	444/1314 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GSAAGAGASEGAVGPGGNPVTFEFDNTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNT 145
            |:..|....:..|.|...|.|....:...||.:|.|..|       .|.:.    .|..:|.:..
Human   229 GTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGC-------LLRNL----IDGISLGLTL 282

  Fly   146 RSFDIWCYECDMKICSNLRKNLLECVELVKKLAQKP------------------PTSTVTPSTPT 192
            |.:|::..|.:        :.|:....:..|:.||.                  .|..:...|
Human   283 RLWDVYLVEGE--------QVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDT-- 337

  Fly   193 ISYIEEKLKAALEHLTPIVPMTGGSFDDSSSR--GSLA----AAGGGGGVGSSRNRQVAIPMPPP 251
               :.:.|:|:.:.||    ...|.....:.|  ||||    .|..||.......|| |.|.||.
Human   338 ---VLKHLRASTKKLT----RKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQ-APPGPPA 394

  Fly   252 E---PSSGLS---TSDSLTSVPGMAKRIDQYSATT----------NGNTGNKRLL---------- 290
            :   |....|   .|...|..||.|.|.|.|...|          .|..|:.|.|
Human   395 QFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPT 459

  Fly   291 ------------------------------------------------------TLETPRIENER 301
                                                                  |..:.:|:.::
Human   460 DLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQK 524

  Fly   302 LPRVR---GLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPG-GTFTIKDKGDIELP 362
            :|..:   ||:|||||||.|:.:||::.|           :|..::.:.| ..:.:.....|.:
Human   525 VPTEKGATGLSNLGNTCFMNSSIQCVSNT-----------QPLTQYFISGRHLYELNRTNPIGM- 577

  Fly   363 MIKGTLSSWGGLTAALANALEELQAG--GSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLE 425
              ||.::...|      :.::||.:|  .|| .|.||...:....|:|.|..|.|:.|||..||:
Human   578 --KGHMAKCYG------DLVQELWSGTQKSV-APLKLRRTIAKYAPKFDGFQQQDSQELLAFLLD 633

  Fly   426 SVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQ-----VFRGFLVS 485
            .: :|||.|........|  ||.|.....|        ...:|.|..||..:     :|.|.|.|
Human   634 GL-HEDLNRVHEKPYVEL--KDSDGRPDWE--------VAAEAWDNHLRRNRSIIVDLFHGQLRS 687

  Fly   486 TLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLT-SSSSSVTPSTGQPTIN--TK 547
            .:.|:.|.::|.|.:.|..:|||:.::...         :|.:| ......||......:|  .|
Human   688 QVKCKTCGHISVRFDPFNFLSLPLPMDSYM---------DLEITVIKLDGTTPVRYGLRLNMDEK 743

  Fly   548 FTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGN 612
            :|.             |........|.:..|:...:......|...:..||..|:::|
Human   744 YTG-------------LKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSG------- 788

  Fly   613 ELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSS-VTTSEHSDADVEDNLVEDTAAPS 676
                       .|.:.                  |....|| ::.|..:..|.       :::||
Human   789 -----------FLCAF------------------EIPVPSSPISASSPTQIDF-------SSSPS 817

  Fly   677 TNNVPSSTASLTAPSKTYMDSNG---NAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTAT 738
            ||.:.:.|.:...|...:: .||   ...|.|.:::.|               :|:.....|:..
Human   818 TNGMFTLTTNGDLPKPIFI-PNGMPNTVVPCGTEKNFT---------------NGMVNGHMPSLP 866

  Fly   739 NSSTS-----------------TSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASV 786
            :|..:                 .|...|..|:.|..|          :.|.::.|.......|..
Human   867 DSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPL----------IVPCTVHTRKKDLYDAVW 921

  Fly   787 IRQVSVGAE----QGASNGTEDADG--------EAKAIEQ--------PEKTPSQAQAMAQAQAR 831
            | |||..|.    |.||...:|.|.        ..:.:::        |:....:...:...:.|
Human   922 I-QVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCKIDCGEDR 985

  Fly   832 TKRVRTQSYSDW-STTIAPRYQCE-----DGECSVQ-------------SCLNNFTAVELMTGQN 877
            ..........|| .|.:..|||..     |...||:             |||..||:.|.:....
Human   986 AFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESE 1050

  Fly   878 KVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQ------------------- 923
            ...|..|            ..:..|||:|.:...|..||:||||||
Human  1051 MYYCSKC------------KTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRES 1103

  Fly   924 ------LGPR----CIFRKLT---RPVSYPNLL-------------------------DIAAFCG 950
                  |.||    |..:.||   ..:|.|.:|                         .::|...
Human  1104 FDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANIS 1168

  Fly   951 SKVKNLPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQ 1015
            |..|..|:..||......:......:|.....|.....::: |::...:|     |..||..||.
Human  1169 SSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRL-PQIGSKNK-----PSSSKKNLDA 1227

  Fly  1016 DDD----QLKKLEELLAKEKAR----------EQHLKVLDD-------------SDDFSNS---- 1049
            ..:    |:.:|.:.|::...|          :.|...|.:             .|.:||.
Human  1228 SKENGAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQLGN 1292

  Fly  1050 -SSNSSTSDESQ-TPATPLEEQQTQQAQQP--QQPQQLEEAANVRAPPGKWYYVSDSRVQEVSED 1110
             |...||.|:.: |...|:...........  .....:..|.|   |..|||..:||..:|:..|
Human  1293 HSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKN---PNCKWYCYNDSSCEELHPD 1354

  Fly  1111 TALKAQAYLLFYER 1124
            ......||:||||:
Human  1355 EIDTDSAYILFYEQ 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	11/50 (22%)
		Peptidase_C19	307..>512	CDD:271592	62/212 (29%)
		Peptidase_C19K	<849..1123	CDD:239132	80/383 (21%)
USP6	NP_001291213.1	TBC	97..312	CDD:214540	21/101 (21%)
		DUF4607	<332..407	CDD:292024	22/84 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..380		11/35 (31%)
		UBP12	<528..1114	CDD:227847	149/721 (21%)
		Peptidase_C19	533..>723	CDD:271592	63/230 (27%)
		Peptidase_C19	<1023..1367	CDD:271592	74/364 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1231		20/116 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1384..1406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900