Protein Alignment Usp16-45 and USP45

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001073950.1
• Gene: USP45 / 85015
• HGNCID: 20080
• Length: 814
• Species: Homo sapiens
• Alignment Length: 1139
• Identity: 308/1139 - (27%)
• Similarity: 452/1139 - (39%)
• Gaps: 360/1139 - (31%)

  Fly     4 KRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTASCQHIKKAVDAARLRRLLKSTGLLY 68
            ||.....|.|.|.|..       .||              :|||:..|:....::|.: :..|..
Human    18 KRPTVPHDEDSSDDIA-------VGL--------------TCQHVSHAISVNHVKRAI-AENLWS 60

  Fly    69 ECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLWLCLKCGSQLCGR-ARHKHALEHYQ 132
            .||:|.|              |.....|...:|    :.:|||||||.|.||: :..:|:|:|::
Human    61 VCSECLK--------------ERRFYDGQLVLT----SDIWLCLKCGFQGCGKNSESQHSLKHFK 107

  Fly   133 TPHSDSHALAMNTRSFDIWCYECDMKICSNLRKNLL-ECVELVKKLAQKPPTSTVTPSTPTISYI 196
            :..::.|.:.:|..::.|||||||.|:.::..|.:| :.|:.::|.|.|..||..   :..:...
Human   108 SSRTEPHCIIINLSTWIIWCYECDEKLSTHCNKKVLAQIVDFLQKHASKTQTSAF---SRIMKLC 169

  Fly   197 EEKLKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSD 261
            |||.:.                 |...:|           |..||               ||
Human   170 EEKCET-----------------DEIQKG-----------GKCRN---------------LS--- 188

  Fly   262 SLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQ 326
                                                       |||:||||||||||||||.|||
Human   189 -------------------------------------------VRGITNLGNTCFFNAVMQNLAQ 210

  Fly   327 TPFLLSVLKELSEPGEEF-ILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAAL---ANALEELQA 387
            |..|..::.|:.|...:. |.|        ..|.:|..:...||..|.||:||   .::::|.:.
Human   211 TYTLTDLMNEIKESSTKLKIFP--------SSDSQLDPLVVELSRPGPLTSALFLFLHSMKETEK 267

  Fly   388 GGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNS 452
            |  ..:|:.||::||.|.|:|....|.|:.|||..||::||.|:.||.|..||:  .:.:....:
Human   268 G--PLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILK--AFNNPTTKT 328

  Fly   453 VSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPP 517
            ..:|.|:|.|.||.: |.::...:::|.|.|.||:.|::|.|:|:..:.|:|:|||:..|:...|
Human   329 ADDETRKKVKAYGKE-GVKMNFIDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKP 392

  Fly   518 ---QRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQV 579
               .|......|..|....    .:|..||..                 :|...||. ..|.|:.
Human   393 LLWGRMNKYRSLRETDHDR----YSGNVTIEN-----------------IHQPRAAK-KHSSSKD 435

  Fly   580 KKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNG 644
            |.:....||..|.....:..:...|.|...||         |....|||...:.:.|:      .
Human   436 KSQLIHDRKCIRKLSSGETVTYQKNENLEMNG---------DSLMFASLMNSESRLNE------S 485

  Fly   645 QTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRD 709
            .|:||...:..:..:.|||.|               ||.:.|.:..:..:..|:|:...|
Human   486 PTDDSEKEASHSESNVDADSE---------------PSESESASKQTGLFRSSSGSGVQP----- 530

  Fly   710 DTPEHMDKDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASL 774
            |.|.:                    |.:......|..|.:.:......:|        .|..:|.
Human   531 DGPLY--------------------PLSAGKLLYTKETDSGDKEMAEAIS--------ELRLSST 567

  Fly   775 VTAGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQS 839
            ||                        |.:|.|.|    .||....:....:     ..|.:|:.|
Human   568 VT------------------------GDQDFDRE----NQPLNISNNLCFL-----EGKHLRSYS 599

  Fly   840 YSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCT-------QRINGSDPKAKS 897
            ..:...|::..|.....|||:||||..||::||:.|.||:.|::||       :..:.::.|.:.
Human   600 PQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYQEETSFAEKKVEG 664

  Fly   898 VNTNATKQLLVSSPPAVLILHLKRF-QLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDR 961
            |.|||.||||:|:.||||||||||| |.|  ...||:.|.|.:|.:||:|.||.:..||....|
Human   665 VYTNARKQLLISAVPAVLILHLKRFHQAG--LSLRKVNRHVDFPLMLDLAPFCSATCKNASVGD- 726

  Fly   962 KQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEEL 1026
               |:||.|||:|||||.|..||||||||||
Human   727 ---KVLYGLYGIVEHSGSMREGHYTAYVKVR---------------------------------- 754

  Fly  1027 LAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVRA 1091
                                              ||:..|.|..|::...|    .|:.|.|..|
Human   755 ----------------------------------TPSRKLSEHNTKKKNVP----GLKAADNESA 781

  Fly  1092 PPGKWYYVSDSRVQEVSEDTALKAQAYLLFYERI 1125
              |:|.:|||:.:|.|.|..||.||||||||||:
Human   782 --GQWVHVSDTYLQVVPESRALSAQAYLLFYERV 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	22/51 (43%)
		UBP12	<307..990	CDD:227847	210/697 (30%)
		Peptidase_C19	307..>512	CDD:470612	79/208 (38%)
		Peptidase_C19K	<849..1123	CDD:239132	103/281 (37%)
USP45	NP_001073950.1	Interaction with ERCC1. /evidence=ECO:0000269|PubMed:25538220	1..62		14/65 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		3/9 (33%)
		zf-UBP	62..132	CDD:460464	28/87 (32%)
		Peptidase_C19	191..>387	CDD:470612	79/208 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	418..443		7/42 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	479..533		15/79 (19%)
		Peptidase_C19K	<603..811	CDD:239132	104/287 (36%)