Protein Alignment Usp16-45 and USP32

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: XP_011523673.1
• Gene: USP32 / 84669
• HGNCID: 19143
• Length: 1634
• Species: Homo sapiens
• Alignment Length: 1031
• Identity: 201/1031 - (19%)
• Similarity: 329/1031 - (31%)
• Gaps: 387/1031 - (37%)

  Fly   296 RIENERLPRVR---GLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPG-GTFTIKDK 356
            :|:..::|..:   ||:|||||||.|:.:||::.|           :|..::.:.| ..:.:...
Human   751 KIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNT-----------QPLTQYFISGRHLYELNRT 804

  Fly   357 GDIELPMIKGTLSSWGGLTAALANALEELQAGGSV-FTPRKLFDRLCVKCPQFTGGDQHDAHELL 420
            ..|.:   ||.::...|      :.::||.:|... ..|.||...:....|:|.|..|.|:.|||
Human   805 NPIGM---KGHMAKCYG------DLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELL 860

  Fly   421 RQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQ-----VFR 480
            ..||:.: :|||.|........|  ||.|.....|        ...:|.|..||..:     :|.
Human   861 AFLLDGL-HEDLNRVHEKPYVEL--KDSDGRPDWE--------VAAEAWDNHLRRNRSIVVDLFH 914

  Fly   481 GFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTIN 545
            |.|.|.:.|:.|.::|.|.:.|..:|||:.::...         .|.:|
Human   915 GQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYM---------HLEIT---------------- 954

  Fly   546 TKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGN 610
                  .:....::|                                  .|....||::...:|.
Human   955 ------VIKLDGTTP----------------------------------VRYGLRLNMDEKYTGL 979

  Fly   611 GNELAE--SVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTT------------SSVTTSEHSD 661
            ..:|::  .::.:...||.:   .|.......|.|.:...|.:            |.::.|..:.
Human   980 KKQLSDLCGLNSEQILLAEV---HGSNIKNFPQDNQKVRLSVSGFLCAFEIPVPVSPISASSPTQ 1041

  Fly   662 ADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNG---NAQPPGEKRDDTPEHMDKDSLEED 723
            .|.       :::||||.:.:.|.:...|...:: .||   ...|.|.:::.|
Human  1042 TDF-------SSSPSTNEMFTLTTNGDLPRPIFI-PNGMPNTVVPCGTEKNFT------------ 1086

  Fly   724 ENDSGIATSPAPTATNSSTS-----------------TSATGNNNSVAGSGLSGSSGALEDPLAP 771
               :|:.....|:..:|..:                 .|:..|..|:.|..|          :.|
Human  1087 ---NGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSSQKNRPSLFGMPL----------IVP 1138

  Fly   772 ASLVTAGLSEKGA---SVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTK 833
            .::.|.......|   .|.|..|....|.|||..:|.|                .:|......|.
Human  1139 CTVHTRKKDLYDAVWIQVSRLASPLPPQEASNHAQDCD----------------DSMGYQYPFTL 1187

  Fly   834 RVRTQSYS--------------------------------DWS-TTIAPRYQCE-----DGECSV 860
            ||..:..:                                ||. |.:..|||..     |...||
Human  1188 RVVQKDGNSCAWCPWYRFCRGCKIDCGEDRAFIGNAYIAVDWDPTALHLRYQTSQERVVDEHESV 1252

  Fly   861 Q-------------SCLNNFTAVELMTGQNKV-GCDSCTQRINGSDPKAKSVNTNATKQLLVSSP 911
            :             |||..||:.|.: |:|:: .|..|            ..:..|||:|.:...
Human  1253 EQSRRAQAEPINLDSCLRAFTSEEEL-GENEMYYCSKC------------KTHCLATKKLDLWRL 1304

  Fly   912 PAVLILHLKRFQ-------------------------LGPR----CIFRKLT---RPVSYPNLL- 943
            |.:||:||||||                         |.||    |..:.||   ..:|.|.:|
Human  1305 PPILIIHLKRFQFVNGRWIKSQKIVKFPRESFDPSAFLVPRDPALCQHKPLTPQGDELSEPRILA 1369

  Fly   944 ------DIAAFCG------------------SKVKNLPNIDRKQKKLLYALYGVVEHSGGMYGGH 984
                  |..:..|                  |..|..|:..||              ||......
Human  1370 REVKKVDAQSSAGEEDVLLSKSPSSLSANIISSPKGSPSSSRK--------------SGTSCPSS 1420

  Fly   985 YTAYVKVRPKVAPGDKRWKFLPH-GSKAELDQDDD-----------QLKKLEELLAK-------- 1029
            ..:.....|:.....|....||. |||.:|....:           |:.:|.:.|::
Human  1421 KNSSPNSSPRTLGRSKGRLRLPQIGSKNKLSSSKENLDASKENGAGQICELADALSRGHVLGGSQ 1485

  Fly  1030 -EKAREQHLKV------LDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAA 1087
             |....|..:|      |.:.:...|..||....:.|:..:|..:.:.|          :::...
Human  1486 PELVTPQDHEVALANGFLYEHEACGNGYSNGQLGNHSEEDSTDDQREDT----------RIKPIY 1540

  Fly  1088 NVRA-------------------PPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
            |:.|                   |..|||..:||..:|:..|......||:||||:
Human  1541 NLYAISCHSGILGGGHYVTYAKNPNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464
		UBP12	<307..990	CDD:227847	162/835 (19%)
		Peptidase_C19	307..>512	CDD:470612	60/211 (28%)
		Peptidase_C19K	<849..1123	CDD:239132	82/395 (21%)
USP32	XP_011523673.1	EFh	253..309	CDD:238008
		EF-hand_7	286..358	CDD:463900
		UBP12	534..1346	CDD:227847	148/755 (20%)
		UCH	<1261..1594	CDD:425685	75/369 (20%)