DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp16-45 and usp19

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_012816883.1	Gene:	usp19 / 780341	XenbaseID:	XB-GENE-5869969	Length:	1478	Species:	Xenopus tropicalis

Alignment Length:	1057	Identity:	230/1057 - (21%)
Similarity:	345/1057 - (32%)	Gaps:	384/1057 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 GGVGSSRNRQVAIPMPPP-----EPSS---GLSTSDSLTSVPGMAKR-----IDQYSA---TTNG 282
            |.||.::   ||:|..||     :|.|   .||..:...:|.....|     :|:.|:   |.:.
Frog   534 GAVGGAK---VAMPAGPPPHDKTQPGSNQHSLSNKEEARAVEKEKPRAEDTGLDKVSSRTPTDHV 595

  Fly   283 NTGNKRLLTLETP---------------RIENERLPRV-----RGLTNLGNTCFFNAVMQCLAQT 327
            :..:::||:...|               .::.|...||     .||.|||||||.|:|:|.|:.|
Frog   596 SVKSEQLLSSPKPTCMVPPMTHSAVSSENVQEEEEKRVCPPGFTGLVNLGNTCFMNSVIQSLSNT 660

  Fly   328 PFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAG-GSV 391
            ..|....::.|...|                   ......|.:.|.|..:.|..|..|..| ...
Frog   661 RELRDYFQDRSFESE-------------------INCNNPLGTGGRLAVSFAVLLRALWKGTHHA 706

  Fly   392 FTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYK---DQDVNSV 453
            |.|.||...:..|..||||..||||.|.:..||:.: :|||.|     :||..|.   |.| ...
Frog   707 FQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL-HEDLNR-----IQNKPYTETVDSD-GRP 764

  Fly   454 SEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQ 518
            .||:..:..:......|..:  ..:|:|...|.|.|..|..||...:.||.:.:|:       ||
Frog   765 DEEVADEAWLRHKMRNDSFV--VDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPL-------PQ 820

  Fly   519 RRK------------PSP-----ELSLTSSSS-----SVTPSTGQPTINTKFTD----------- 550
            ::|            ..|     .:|..:||:     |::.|......|.:..:
Frog   821 KQKVLTVYYFAREPHKKPIKFLVSISKENSSAAEVLESISKSVRVKAENLQLAEVVKNRFQRIFR 885

  Fly   551 GSVNFTASSPSFFLHAHEAASLGPSKSQV-----------------------KKEKERQRKAKRA 592
            .|.:..:.||:..|...|..|...||.:|                       ||:...:.|.||.
Frog   886 PSCSLDSVSPNDLLFCFEVLSKELSKERVVVFQVQQRPQVPSIPITKCAACQKKQMSEEEKLKRC 950

  Fly   593 AKKRQKSSLNLNGNDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTS 657
            .:..:          .|..|::.:.....|...|.     ...|.|........|...|.|...
Frog   951 TRCYR----------VGYCNQVCQKSHWPDHKTAC-----RPENIGYPFLISVPESRLTYSRLA- 999

  Fly   658 EHSDADVEDNLVEDTAAPSTN-----NVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMD- 716
                     .|:|..|..|.|     .:|..|:...||           ||...::.|.|...|
Frog  1000 ---------QLLEGYARYSVNVFQPPFIPGRTSPDHAP-----------QPLSSEKADLPPQSDL 1044

  Fly   717 ---KDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVT-- 776
               .:|.||:::...:.:|  .|.....|..||:|::..|.|          :.|....||.:
Frog  1045 PLLGESSEEEKDFHSVQSS--QTTLPPLTCLSASGDSGIVHG----------KPPGDRVSLYSTD 1097

  Fly   777 AGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSY- 840
            :|.||.....:|::             |:.||.:.|.:....|..|.|..| |:.:..|...::
Frog  1098 SGFSEHSTDTVREM-------------DSGGEKETIYEKSVKPEAAVAGFQ-QSESVNVHASAFY 1148

  Fly   841 ------------------------SDWSTTI---------------APRYQCED----------- 855
                                    .|.|..:               :...:||:
Frog  1149 INVIDPNNKEMKLEDKGESPLELTEDCSLALVWKNNERAKEFVLVESKELECEEDPGSASEAARA 1213

  Fly   856 GECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLK 920
            |..::..|||.||..|::..:....|..|.|            :..|:|||::...|.:||:.||
Frog  1214 GLFTLDQCLNLFTKPEVLAPEEAWYCPKCNQ------------HREASKQLMLWRLPNILIIQLK 1266

  Fly   921 RFQLGPRCIFR------KLTRPVSYP-NLLDIAAFC-GSKVKNLPNIDRKQKKLLYALYGVVEHS 977
            ||.      ||      |:...|.:| ..||::.|| |.|        ...::.:|.||.|:.|.
Frog  1267 RFS------FRTFIWRDKINDMVDFPVRNLDLSTFCIGQK--------EDHQRPIYDLYAVINHY 1317

  Fly   978 GGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKEKAREQHLKVLDD 1042
            |||.|||||||.::     |.:|
Frog  1318 GGMIGGHYTAYARL-----PNEK------------------------------------------ 1335

  Fly  1043 SDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVRAPPGKWYYVSDSRVQEV 1107
                     ||..||..                                    |....||.|..|
Frog  1336 ---------NSQRSDVG------------------------------------WRLFDDSTVTTV 1355

  Fly  1108 SEDTALKAQAYLLFYER 1124
            .|...:...||:|||.|
Frog  1356 DESQVVTRYAYVLFYRR 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	63/208 (30%)
		Peptidase_C19K	<849..1123	CDD:239132	65/292 (22%)
usp19	XP_012816883.1	p23_like	53..135	CDD:107220
		p23_CS_SGT1_like	435..515	CDD:107223
		USP19_linker	506..637	CDD:293210	23/105 (22%)
		Peptidase_C19	629..>744	CDD:271592	42/134 (31%)
		Peptidase_C19	640..>826	CDD:271592	66/220 (30%)
		USP7_C2	810..>929	CDD:291217	22/125 (18%)
		zf-MYND	933..975	CDD:280009	8/51 (16%)
		Peptidase_C19R	<1217..1371	CDD:239139	62/271 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910