Protein Alignment Usp16-45 and Usp45

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_690038.1
• Gene: Usp45 / 77593
• MGIID: 101850
• Length: 813
• Species: Mus musculus
• Alignment Length: 1146
• Identity: 304/1146 - (26%)
• Similarity: 465/1146 - (40%)
• Gaps: 365/1146 - (31%)

  Fly    10 RDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTA--SCQHIKKAVDAARLRRLLKSTGLLYECSQ 72
            |..|.|.|...:...:::.| .|...|.:.....  :|||:..||....:::.: :..|...||:
Mouse     2 RVKDPSKDLPEKGKRNKRPL-LPHDEDSSDDIAVGLTCQHVSYAVSVNHVKKAV-AESLWSVCSE 64

  Fly    73 CQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLWLCLKCGSQLCGR-ARHKHALEHYQTPHS 136
            |.|..:..               .|.||   ....:|||||||.|.||: :..:|:|.|:::..:
Mouse    65 CLKERRFC---------------DGQPV---LPADVWLCLKCGLQGCGKNSESQHSLRHFKSSGT 111

  Fly   137 DSHALAMNTRSFDIWCYECDMKICSNLRKNLL-ECVELVKKLAQKPPTSTVTPSTPTISYIEEKL 200
            :||.:.::..::.||||||:.|:.::..|.:| :.|:.::|.|.|..|...   :..|...|||.
Mouse   112 ESHCVVISLSTWVIWCYECNEKLSTHCNKKVLAQIVDFLQKHAFKTQTGAF---SRIIKLCEEKR 173

  Fly   201 KAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTS 265
            :|
Mouse   174 EA--------------------------------------------------------------- 175

  Fly   266 VPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFL 330
              |..|:            |.|..           .:|.|:|:||||||||||||:|.||||..|
Mouse   176 --GEIKK------------GKKGC-----------TVPSVKGITNLGNTCFFNAVIQNLAQTYIL 215

  Fly   331 LSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAAL---ANALEELQAGGSVF 392
            ..::.|:.|.|.:|     ..::.....:| |::. .|||.|.||:||   .::::|.:.|  ..
Mouse   216 FELMNEIKEDGTKF-----KISLSSAPQLE-PLVV-ELSSPGPLTSALFLFLHSMKEAEKG--PL 271

  Fly   393 TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEM 457
            :|:.||::||.|.|:|.|..|.|:.|||..||::||.|:.||.|..||:  .:.:....:..:|.
Mouse   272 SPKVLFNQLCQKAPRFKGFQQQDSQELLHHLLDAVRTEETKRIQASILK--AFNNPTTKTADDET 334

  Fly   458 RQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPP----- 517
            |:|.|.||.: |.::...:::|.|.|.||:.|::|.|:|:..:.|:|:|||:..|:...|
Mouse   335 RKKVKAYGKE-GVKMNFIDRIFIGELTSTVMCEECANISTMKDPFIDISLPIIEERVSKPVLLGK 398

  Fly   518 -QRRKPSPELSLTSSSSSVTPSTG-QPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVK 580
             .:.:...|.....:..:||.... ||..:.|.         |||:             .|:|:.
Mouse   399 MSKCRSLQETDQDHNKGTVTVGNAHQPRASRKH---------SSPN-------------DKNQLS 441

  Fly   581 KEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQ 645
            .:::..||   ...:.:|:.:....||:...:..|.::                          .
Mouse   442 HDRKHLRK---WPSEEEKTVVTHPKNDNLEASPPASTL--------------------------S 477

  Fly   646 TEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNA-QPPGEKRD 709
            ||.|...|:|.....||.:|.::..|:.|    :.|...:......::..||.|:| |.|
Mouse   478 TEASLNESLTDGSERDASLESSVDADSEA----SEPEIASKQPVLLRSRGDSCGHAEQHP----- 533

  Fly   710 DTPEHMDKDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLA---P 771
                |:                                                    |||   |
Mouse   534 ----HL----------------------------------------------------PLASELP 542

  Fly   772 ASLVTAGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVR 836
            .:..|.|..|:.|..|.::.:   .|...|..|...|    :||...|:..     ..:..|..|
Mouse   543 QAKETHGGEEEMAEAIAELHL---SGTVTGNRDFHRE----KQPLNVPNNL-----CFSEGKHTR 595

  Fly   837 TQSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQR-------INGSDPK 894
            ..|..:...|::..|.....||||||||..||::||:.|.||:.|:.||::       .:.::.|
Mouse   596 LHSAQNAFQTLSQSYVTTSKECSVQSCLYQFTSMELLMGNNKLLCEDCTEKRRKCHKETSSAEKK 660

  Fly   895 AKSVNTNATKQLLVSSPPAVLILHLKRF-QLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPN 958
            |..|.|||.||||:|:.||:|||||||| |.|  ...||:.|.|.:|..||:|.||.:..||:
Mouse   661 AGGVYTNARKQLLISAVPAILILHLKRFHQAG--LSLRKVNRHVDFPLTLDLAPFCAATCKNI-- 721

  Fly   959 IDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKL 1023
              ...:|:||.|||:|||||.|.|||||||||||            :|.             :||
Mouse   722 --SVGEKVLYGLYGIVEHSGSMRGGHYTAYVKVR------------VPS-------------RKL 759

  Fly  1024 EELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAAN 1088
            .|.:...|.                                                     ||.
Mouse   760 SECITGRKT-----------------------------------------------------AAG 771

  Fly  1089 VRAPPGK----WYYVSDSRVQEVSEDTALKAQAYLLFYERI 1125
            ::.|.|:    |.:|||:.||.|.|..||.|||||||||||
Mouse   772 LKEPDGELGGHWVHVSDTYVQVVPESRALSAQAYLLFYERI 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	21/51 (41%)
		UBP12	<307..990	CDD:227847	210/704 (30%)
		Peptidase_C19	307..>512	CDD:470612	80/207 (39%)
		Peptidase_C19K	<849..1123	CDD:239132	103/285 (36%)
Usp45	NP_690038.1	Interaction with ERCC1. /evidence=ECO:0000305|PubMed:25538220	1..62		13/61 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		6/25 (24%)
		zf-UBP	62..132	CDD:460464	28/87 (32%)
		Peptidase_C19	192..>388	CDD:470612	80/207 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	405..552		41/262 (16%)
		Peptidase_C19K	<587..810	CDD:239132	107/306 (35%)