Protein Alignment Usp16-45 and Usp20

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_083122.1
• Gene: Usp20 / 74270
• MGIID: 1921520
• Length: 916
• Species: Mus musculus
• Alignment Length: 1144
• Identity: 214/1144 - (18%)
• Similarity: 319/1144 - (27%)
• Gaps: 529/1144 - (46%)

  Fly    45 CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLW 109
            |.|:....:..:...||||.|   .|..|                 |..||           .||
Mouse     8 CPHLDCIGEVTKEDLLLKSKG---TCQSC-----------------GVAGP-----------NLW 41

  Fly   110 LCLK--CGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKICSNLRKNLLECVE 172
            .||:  |....||.:...|:..|.|.   ..|.|.:|..:|.:|||.|:.::
Mouse    42 ACLQVTCPYVGCGESFADHSSIHAQV---KKHNLTVNLTTFRVWCYACEREV------------- 90

  Fly   173 LVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGVG 237
                                  ::|::|..   ||                             .
Mouse    91 ----------------------FLEQRLAV---HL-----------------------------A 101

  Fly   238 SSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENERL 302
            ||..|......|||        |..|.:||        .:....|          |:...:::..
Mouse   102 SSSARLSEQDSPPP--------SHPLKAVP--------IAVADEG----------ESESEDDDLK 140

  Fly   303 PR-VRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKG 366
            || :.|:.||||:|:.||.:|.|:..|           |..:|.|..|.....||
Mouse   141 PRGLTGMKNLGNSCYMNAALQALSNCP-----------PLTQFFLECGGLVRTDK---------- 184

  Fly   367 TLSSWGGLTAALANALEEL------QAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLE 425
                    ..||..:.::|      :...|...|..|...:.:..|.|.|..|.|..|.||.|::
Mouse   185 --------KPALCKSYQKLISEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMD 241

  Fly   426 SVRNEDLKRYQRVILQNL-GYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTC 489
            .: :|:||......:..| ..:|.| :|.::|.|.         ||
Mouse   242 QL-HEELKEPMVAAVAALTDARDSD-SSDTDERRD---------GD------------------- 276

  Fly   490 QDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVN 554
                                          |.||.:..|:..|||   ..|:       .||
Mouse   277 ------------------------------RSPSEDEFLSCDSSS---DRGE-------GDG--- 298

  Fly   555 FTASSPSFFLHAHEAASLGPSKSQVK-----------KEKERQRKAKRAAKKRQKSSLNLNGNDS 608
                         :....|.||::::           .||||.:..|.:..:::.:|
Mouse   299 -------------QGRGGGSSKAEMELLISDEAGRAISEKERMKDRKFSWGQQRTNS-------- 342

  Fly   609 GNGNELAESVDQD---DASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVE 670
                   |.||:|   |.::|||                                     |....
Mouse   343 -------EQVDEDADVDTAMASL-------------------------------------DEQSR 363

  Fly   671 DTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSP-- 733
            :...||    |.||:....|     :.:..|......|..:|.|      ...|..|.:::||
Mouse   364 EAQPPS----PRSTSPCQTP-----EPDNEAHIRSSSRPCSPVH------HHHEGHSKLSSSPPR 413

  Fly   734 ------APTATNSSTSTSATGNN-------NSVAGSGLSGSSGALEDPLA------------PAS 773
                  .|:.........:||..       .||.....:||..:|...|.            ..|
Mouse   414 ASPVRMGPSYVLKKAQVPSTGGRRRKEQSYRSVISDVFNGSVLSLVQCLTCDRVSTTVETFQDLS 478

  Fly   774 LVTAGLSE--KGASVIRQVSVGAEQGASNGTEDADG-EAKAIEQPEK-----TPSQAQAMAQAQA 830
            |...|..:  |..|.|.| :|.|:.||...:..:.| .|..:|...:     |||..
Mouse   479 LPIPGKEDLAKLHSAIYQ-NVPAKPGACGDSYSSQGWLAFIVEYIRRFVVSCTPSWF-------- 534

  Fly   831 RTKRVRTQSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKA 895
                        |...:           :::.||..|.|.:.:.|.|...|:.|.:..||
Mouse   535 ------------WGPVV-----------TLEDCLAAFFAADELKGDNMYSCERCKKLRNG----- 571

  Fly   896 KSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYP-NLLDIAAF----CGSKVKN 955
                   .|...|...|.:|.:|||||:......| |::..||:| ..||:..|    |.|:|..
Mouse   572 -------VKYCKVLCLPEILCVHLKRFRHEVMYSF-KVSSHVSFPLEGLDLRPFLAKECTSQVTT 628

  Fly   956 LPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQL 1020
                        |.|..|:.|.|....|||.||.:
Mouse   629 ------------YDLLSVICHHGTAGSGHYIAYCQ------------------------------ 651

  Fly  1021 KKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEE 1085
                             .|::
Mouse   652 -----------------NVIN-------------------------------------------- 655

  Fly  1086 AANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                    |:||...|..|.||.|......:||:|||.:
Mouse   656 --------GQWYEFDDQYVTEVHETVVQNVEAYVLFYRK 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	18/52 (35%)
		UBP12	<307..990	CDD:227847	152/743 (20%)
		Peptidase_C19	307..>512	CDD:470612	43/211 (20%)
		Peptidase_C19K	<849..1123	CDD:239132	53/278 (19%)
Usp20	NP_083122.1	zf-UBP	30..90	CDD:460464	23/90 (26%)
		UBP12	<73..688	CDD:227847	190/1045 (18%)
		UCH	145..684	CDD:425685	164/876 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..420		50/313 (16%)
		DUSP	704..787	CDD:197831
		DUSP	812..896	CDD:197831