Protein Alignment Usp16-45 and Usp16

DIOPT Version :9

• Sequence 1: NP_001284890.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_077220.2
• Gene: Usp16 / 74112
• MGIID: 1921362
• Length: 825
• Species: Mus musculus
• Alignment Length: 1125
• Identity: 309/1125 - (27%)
• Similarity: 452/1125 - (40%)
• Gaps: 333/1125 - (29%)

  Fly    27 KGLGSPG--QSDGATPTTASCQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGAS 89
            ||..:|.  .|:.|.|.   |:|::|.::...|::.|.:.    |.:.||.. ||..........
Mouse     7 KGRSAPDTVASESAEPV---CRHLRKGLEQGNLKKALVNV----EWNICQDC-KTDNKVKDKPEE 63

  Fly    90 EGAVGPGGNPVTFEFDNTLWLCLKCGSQLCGR-ARHKHALEHYQTPHSDSHALAMNTRSFDIWCY 153
            |..            |.::|||||||.|.||| ::.:|||:||.||.|:.|.|.::..::.:|||
Mouse    64 EAE------------DPSVWLCLKCGHQGCGRDSQEQHALKHYTTPRSEPHYLVLSLDNWSVWCY 116

  Fly   154 ECD--MKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIE-EKLKAALEHLTPIVPMTG 215
            :||  :|.||:.|  |.:.|:.|:|.|   ...|..|:.....:|| |..|...|
Mouse   117 KCDEEVKYCSSNR--LGQVVDYVRKQA---GVRTSKPAEKNNGHIELENKKLEKE---------- 166

  Fly   216 GSFDDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATT 280
                                   |:|.|      ..|.|..|:..    ::|     :|..|..|
Mouse   167 -----------------------SKNEQ------EREKSENLAKE----TIP-----MDSASQIT 193

  Fly   281 NGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFI 345
                                    |:||:|||||||||||||.|:|||.|..:|||        :
Mouse   194 ------------------------VKGLSNLGNTCFFNAVMQNLSQTPVLRELLKE--------V 226

  Fly   346 LPGGTFTIKDKGDIEL-PMIKGTLSSWGGLTAALANALEELQAGGS-VFTPRKLFDRLCVKCPQF 408
            ...||....:..|:.| ..::..|...|.||.|::..|.|:|.... |.||::||.::|.|..:|
Mouse   227 KMSGTIVKIEPPDLALTEPLEVNLEPPGPLTLAMSQFLSEMQENKKRVVTPKELFSQVCKKATRF 291

  Fly   409 TGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAG---- 469
            .|..|.|:.||||.||:.:|.|:.:|..:.||:..|   .....:.||::.|.|.|..:..
Mouse   292 KGYQQQDSQELLRYLLDGMRAEEHQRVSKGILKAFG---NSTEKLDEEVKNKVKDYEKKKAIPSF 353

  Fly   470 -DRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSS 533
             |||      |.|.|.||:.|.:|..||..||.|||:||||..::         |.:.|:...:.
Mouse   354 VDRI------FGGELTSTIMCDECRTVSLVHESFLDLSLPVLDDQ---------SGKKSINDKNV 403

  Fly   534 SVTPSTGQPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSK---SQVKKEKERQRKAKRAAKK 595
            .:|..........:..|..:...:..||           |.||   .:.||:.::|.|.:|..:|
Mouse   404 KMTMEEEDKDSEEEKDDSYMKSRSDLPS-----------GTSKHLQKKAKKQAKKQAKNQRRQQK 457

  Fly   596 RQKSSLNLN---GNDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTS 657
            .|:..|:.|   ..|....||     .:.|.:||      |:.....:.|:|..|::|...::.:
Mouse   458 IQERFLHFNELCATDYTEDNE-----READTALA------GEVEVDTDSTHGSQEEATQIELSVN 511

  Fly   658 EHSDADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEE 722
            : .|.|.:::::|.|  |.....|...                    |.|..:|
Mouse   512 Q-KDLDGQESMIERT--PDVQESPEDL--------------------GVKSANT----------- 542

  Fly   723 DENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVI 787
             |:|.||.| |||.                                 .|.....|.|.|:
Mouse   543 -ESDLGIVT-PAPE---------------------------------CPRDFNGAFLEER----- 567

  Fly   788 RQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQ 852
                ...|....||.::.:  ..|...|::...:....:.:..:...|..:.......|:|.|..
Mouse   568 ----TSGELDIINGLKNLN--LNAAVDPDEINIEIPNDSHSAPKVYEVMNEDPETAFCTLANREA 626

  Fly   853 CEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQR-INGSDPKA------KSVNTNATKQLLVSS 910
            ....|||:|.||..||..|.:...||:.|:.|::| .||  |||      :.|.|||.||:|||.
Mouse   627 FSTDECSIQHCLYQFTRNEKLQDANKLLCEVCSRRQCNG--PKANIKGDRRHVYTNAKKQMLVSL 689

  Fly   911 PPAVLILHLKRFQLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYGVVE 975
            .|.||.|||||||.....: ||:.:.:.:|.:||:|.||..|.|   |:..:..::||:||||||
Mouse   690 APPVLTLHLKRFQQAGFNL-RKVNKHIKFPEILDLAPFCTLKCK---NVAEESTRVLYSLYGVVE 750

  Fly   976 HSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKEKAREQHLKVL 1040
            |||.|..||||||                                       |||:....||..|
Mouse   751 HSGTMRSGHYTAY---------------------------------------AKERTASCHLSNL 776

  Fly  1041 DDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVRAPPGKWYYVSDSRVQ 1105
            ....|.                                 ||..|    :.:..|:|:::||:.||
Mouse   777 VLHGDI---------------------------------PQDCE----MESTKGQWFHISDTHVQ 804

  Fly  1106 EVSEDTALKAQAYLLFYERI 1125
            .|.....|.:||||||||||
Mouse   805 AVPITKVLNSQAYLLFYERI 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	26/53 (49%)
		Peptidase_C19	307..>512	CDD:271592	84/211 (40%)
		Peptidase_C19K	<849..1123	CDD:239132	92/280 (33%)
Usp16	NP_077220.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/12 (33%)
		zf-UBP	48..122	CDD:366940	32/86 (37%)
		UBP12	<135..823	CDD:227847	256/972 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	164..184		7/62 (11%)
		Peptidase_C19K	196..>401	CDD:239132	86/230 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..456		14/73 (19%)
		Peptidase_C19K	<624..822	CDD:239132	92/279 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1563
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1826
Isobase	1	0.950	-	0	Normalized mean entropy	S5928
OMA	1	1.010	-	-		QHG47475
OrthoDB	1	1.010	-	-		D278083at2759
OrthoFinder	1	1.000	-	-		FOG0002415
OrthoInspector	1	1.000	-	-		otm43521
orthoMCL	1	0.900	-	-		OOG6_103128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2117
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.690