DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp19

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_006511895.1	Gene:	Usp19 / 71472	MGIID:	1918722	Length:	1361	Species:	Mus musculus

Alignment Length:	1095	Identity:	247/1095 - (22%)
Similarity:	356/1095 - (32%)	Gaps:	383/1095 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 TISYIEEKLKAALEHLTPIVPMTGGSFD------DSSSRGSLAAAGGGGGVGSSRNRQVAIPMPP 250
            ||...:.||:..:|........|....|      .|...|.|.|....|.||.::   ||:|..|
Mouse   383 TIFRWQVKLRNLIEPEQCTFCFTASRIDICLRKRQSQRWGGLEAPATRGAVGGAK---VAVPTGP 444

  Fly   251 -----------PEP--------------------SSGLSTSDSLTSVPGMAKRIDQYSATTNGN- 283
                       |.|                    .|||....:.|.:..:|.:.|.:.|:....
Mouse   445 TPLDSTPPGGGPHPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVAPKPDPHLASPKPTC 509

  Fly   284 ----------TGNKRLLTLETPRIENER--LPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKE 336
                      :|:    ::|....|.::  ||...||.|||||||.|:|:|.|:.|..|.....:
Mouse   510 MVPPMPHSPVSGD----SVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHD 570

  Fly   337 LSEPGE-EFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAG-GSVFTPRKLFD 399
            .|...| .:..|.||                    .|.|....|..|..|..| ...|.|.||..
Mouse   571 RSFEAEINYNNPLGT--------------------GGRLAIGFAVLLRALWKGTHQAFQPSKLKA 615

  Fly   400 RLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNS-------VSEEM 457
            .:..|..||||..||||.|.:..||:.: :|||.|     :||..| .:.|:|       |:||.
Mouse   616 IVASKASQFTGYAQHDAQEFMAFLLDGL-HEDLNR-----IQNKPY-TETVDSDGRPDEVVAEEA 673

  Fly   458 RQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKP 522
            .|:.|:    ..|..:  ..:|:|...|.|.|..|..||...:.||.:.:|:       ||::|.
Mouse   674 WQRHKM----RNDSFI--VDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPL-------PQKQKV 725

  Fly   523 SPELSL------------------TSSSSSVTPSTGQ------------PTINTKFTD---GSVN 554
            .|....                  .||:|.|..|..|            ..|..:|..   .|.:
Mouse   726 LPIFYFAREPHSKPIKFLVSVSKENSSASEVLDSLSQSVHVKPENLRLAEVIKNRFHRVFLPSHS 790

  Fly   555 FTASSPSFFLHAHEAASLGPSKSQVKKEKERQRK-------AKRAAKKRQKSSLNLNGNDSGNGN 612
            ..|.||:..|...|..|...:|.:|...:.:||.       :|.||.:|::.|
Mouse   791 LDAVSPTDVLLCFELLSPELAKERVVVLEVQQRPQVPSIPISKCAACQRKQQS------------ 843

  Fly   613 ELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTS----------SVTTSEHSDADVEDN 667
                  :::.....:.....|..|...::|:.........          ||..|..:.|.:. .
Mouse   844 ------EEEKLKRCTRCYRVGYCNQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLA-Q 901

  Fly   668 LVEDTAAPST---------------NNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDK 717
            |:|..|..|.               :..|..|..|:..|....||......|.|.:..||
Mouse   902 LLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTP----- 961

  Fly   718 DSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSG---SSGALED-PLAPASLVTAG 778
                ..|.|:|......|.......||           ||||.   :||.:|. ||.
Mouse   962 ----VAEGDTGAHRVWPPADRGPVPST-----------SGLSSEMLASGPIEGCPLL-------- 1003

  Fly   779 LSEKGASVIR-QVSVGAEQGASNGTE-----------DADGEAKAIEQPEKTPSQAQ---AMAQA 828
               .|..|.| :.:|...|.:|....           ||....:.:|...:||.:..   ::|..
Mouse  1004 ---AGERVSRPEAAVPGYQHSSESVNTHTPQFFIYKIDASNREQRLEDKGETPLELGDDCSLALV 1065

  Fly   829 QARTKRVRTQSYSDWSTTIAPRYQC-ED----------GECSVQSCLNNFTAVELMTGQNKVGCD 882
            ....:|::     ::....:...:| ||          |..::..|||.||..|::..:....|.
Mouse  1066 WRNNERLQ-----EFVLVASKELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCP 1125

  Fly   883 SCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFR------KLTRPVSYP- 940
            .|.|            :..|:||||:...|.|||:.||||.      ||      |:...|.:|
Mouse  1126 QCKQ------------HREASKQLLLWRLPNVLIVQLKRFS------FRSFIWRDKINDLVEFPV 1172

  Fly   941 NLLDIAAFC-GSKVKNLPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKF 1004
            ..||::.|| |.|.:.||:         |.||.|:.|.|||.||||||..::     |.|:
Mouse  1173 RNLDLSKFCIGQKEEQLPS---------YDLYAVINHYGGMIGGHYTACARL-----PNDR---- 1219

  Fly  1005 LPHGSKAELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQ 1069
                                                           :|..||..
Mouse  1220 -----------------------------------------------SSQRSDVG---------- 1227

  Fly  1070 QTQQAQQPQQPQQLEEAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                                      |....||.|..|.|...:...||:|||.|
Mouse  1228 --------------------------WRLFDDSTVTTVDESQVVTRYAYVLFYRR 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	68/213 (32%)
		Peptidase_C19K	<849..1123	CDD:239132	68/292 (23%)
Usp19	XP_006511895.1	p23_like	58..140	CDD:107220
		p23_CS_SGT1_like	329..425	CDD:107223	9/41 (22%)
		USP19_linker	416..538	CDD:374662	24/128 (19%)
		UBP12	<536..1258	CDD:227847	217/935 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810