Protein Alignment Usp16-45 and usp16

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001139569.1
• Gene: usp16 / 569700
• ZFINID: ZDB-GENE-030131-4153
• Length: 815
• Species: Danio rerio
• Alignment Length: 1154
• Identity: 297/1154 - (25%)
• Similarity: 442/1154 - (38%)
• Gaps: 369/1154 - (31%)

  Fly     1 MVKKRQADSRDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTASCQHIKKAVDAARLRRLLKSTG 65
            |.||:   .:|....|||.:|.               |.|   ||.||:|..:    ..:||...
Zfish     1 MGKKK---VKDRSAGTDSSSET---------------AGP---SCTHIRKGTE----NSVLKKAC 40

  Fly    66 LLYECSQCQKL------------GKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLWLCLKCGSQL 118
            |....|.||..            .:|.|.:.                      .:|:|||||.:.
Zfish    41 LNEHWSSCQDCEQDKPEEKQILEDQTDGESP----------------------AVWMCLKCGHRG 83

  Fly   119 CGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECD-----------MKICSNLRKNLLECVE 172
            |||:.::||::||:||.|:.|.|.::...:.:|||.||           .::.:|:||.:|...:
Zfish    84 CGRSGNQHAIKHYETPRSEPHCLVLSLDVWSVWCYICDDEVQYSSTGQLAQLITNIRKQVLTAPD 148

  Fly   173 L--VKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGG 235
            .  ..|.:.|...|.:..:..|..  |||.|...:        ...|..:.|.:...:||.|...
Zfish   149 KRNASKKSWKEDISVMNSAEQTQD--EEKGKKGKQ--------KSSSKQEDSPKSHQSAAAGSSA 203

  Fly   236 VGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENE 300
            |.|
Zfish   204 VVS-------------------------------------------------------------- 206

  Fly   301 RLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIK 365
                ||||:|||||||||||:|.|:||.:|..:||:::|       ...:|:|......||..::
Zfish   207 ----VRGLSNLGNTCFFNAVVQSLSQTQYLRELLKQIAE-------EKSSFSITPALSSELDPLQ 260

  Fly   366 GTLSSWGGLTAALANALEELQ-AGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRN 429
            ..|...|.||.|:...:.|:| ....|.||::||.::|.|.|:|.|..|.|:.||||.||:.:|.
Zfish   261 IQLERPGSLTLAMCQLMNEIQETKKGVVTPKELFTQVCKKAPRFKGFQQQDSQELLRYLLDGMRA 325

  Fly   430 EDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHN 494
            |:.||....||:.|  |....|..:|:.::..|.|......:.. .::||.|.:.||:.|::|..
Zfish   326 EEAKRVNSGILEAL--KSSGKNFEAEQTKKIVKEYEKDGAPKNF-VDRVFGGAMSSTVMCKECKT 387

  Fly   495 VSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASS 559
            ||...|.|||:|||||.|..:...::|      ......||:....|.|  :...:|:.:....:
Zfish   388 VSLVTEMFLDLSLPVADEAYRKKNQKK------AVQHRHSVSDDGDQDT--SSLANGNEDMPTGT 444

  Fly   560 PSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDAS 624
            .|.:...       .:|.|.||:.:.||   |..|:..|.:|:...|.|        |.|..|:|
Zfish   445 GSKYQQK-------KAKKQAKKQAKNQR---RQQKQGGKVTLDAITNQS--------STDPADSS 491

  Fly   625 LASLGAG-DGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSSTASLT 688
            :.:.... :|.|       :.|..|:....::..:|:: |.:|...|...|.|.||      ..|
Zfish   492 MQTQTVSVNGSA-------DAQPADTNQEDLSLEKHNE-DQDDEEPEQEQAASVNN------RFT 542

  Fly   689 APSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSV 753
            |.|:            .:..:|..|.:::|   |||.:...|
Zfish   543 ALSE------------DQTTEDIAEQVNED---EDEIEQNCA----------------------- 569

  Fly   754 AGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKT 818
                   ....|.:.|...||.|.                :|....|| ||...:.|......:.
Zfish   570 -------EEEELVEELNTMSLTTP----------------SEGDVENG-EDTLEDVKEYTVVNRD 610

  Fly   819 PSQA-QAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCD 882
            |..| :|:|...|..|:                      ||||:|||..||.||.:|..|::.|.
Zfish   611 PELAFRALASRTAPVKQ----------------------ECSVESCLYQFTEVEHLTENNRLMCV 653

  Fly   883 SCTQRING-SDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYPNLLDIA 946
            :||::..| .|...|:|..:|.||:|:|.||.||.|||||||.....:. |:.|.|.:|.:||:|
Zfish   654 TCTKQQPGYKDGCKKAVYRDALKQMLISDPPVVLTLHLKRFQQVAYSVC-KVNRHVQFPQILDLA 717

  Fly   947 AFCGSKVKNLPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKA 1011
            .||.   .|...:...:.::||:|||:|||||.|..||||||||.||..
Zfish   718 PFCS---LNCTGVKEGETQVLYSLYGIVEHSGTMRSGHYTAYVKSRPST---------------- 763

  Fly  1012 ELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQ 1076
                                               .|...|.:.:
Zfish   764 -----------------------------------HNCVQNGTAA-------------------- 773

  Fly  1077 PQQPQQLEEAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYERI 1125
                    .:.:..|..|.|:::|||.|..|.|.....:||||||||:|
Zfish   774 --------ASGDAEASKGSWFHISDSSVHPVPEAKVQSSQAYLLFYEKI 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	23/61 (38%)
		UBP12	<307..990	CDD:227847	206/686 (30%)
		Peptidase_C19	307..>512	CDD:470612	80/205 (39%)
		Peptidase_C19K	<849..1123	CDD:239132	84/274 (31%)
usp16	NP_001139569.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		12/46 (26%)
		zf-UBP	73..124	CDD:460464	23/50 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..200		12/61 (20%)
		UBP12	<209..813	CDD:227847	228/820 (28%)
		Peptidase_C19	209..>406	CDD:470612	80/206 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	411..510		26/131 (20%)
		Peptidase_C19K	<624..812	CDD:239132	85/292 (29%)