Protein Alignment Usp16-45 and usp45

DIOPT Version :9

• Sequence 1: NP_001284890.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: XP_005158432.1
• Gene: usp45 / 564004
• ZFINID: ZDB-GENE-100211-2
• Length: 803
• Species: Danio rerio
• Alignment Length: 1134
• Identity: 292/1134 - (25%)
• Similarity: 469/1134 - (41%)
• Gaps: 374/1134 - (32%)

  Fly    10 RDHDCSTDSGNEDLHHRKGLGSPGQSDGATPTTASCQHIKKAVDAARLRRLLKSTGLLYE-CSQC 73
            ||.|.|.:.|        ||              :|||:.:|||.:.:::.:  ||.|:. ||.|
Zfish    25 RDEDSSDEVG--------GL--------------TCQHVSRAVDLSSVKKAV--TGSLWSVCSDC 65

  Fly    74 QK-----LGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLWLCLKCGSQLCGRARHKHALEHYQT 133
            .|     .|:|||:                       :.:.:|||||.|.|.:|..:|:.:|.|.
Zfish    66 LKERNVLEGETAGA-----------------------HDILVCLKCGFQGCNQAEVQHSTKHQQA 107

  Fly   134 PHSDSHALAMNTRSFDIWCYECDMKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEE 198
            .|||||.:.::..::..||:||..::.::..|         |.|||            |:.::::
Zfish   108 HHSDSHCITISLTTWKAWCFECKEELSTHCNK---------KALAQ------------TLDFLQK 151

  Fly   199 KLKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSL 263
            :                                                       |..:||.:.
Zfish   152 Q-------------------------------------------------------SAKATSGTS 161

  Fly   264 TSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTP 328
            :.:..:.:...:|..|..|          ::|  .|..|..|:|:.|||||||||||||.|:||.
Zfish   162 SKLIKLREEPAEYVDTQRG----------KSP--VNSTLIPVKGINNLGNTCFFNAVMQNLSQTH 214

  Fly   329 FLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEEL-QAGGSVF 392
            .|..:::::.|.|.:..:...|.|       .|..:..||.|...||:|:...|:.: ::|....
Zfish   215 MLNDLIQDVKEKGHKMKISPSTET-------NLGSLTVTLPSPEPLTSAMFLFLQSMKESGKGPV 272

  Fly   393 TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEM 457
            :|:.||::||.|.|:|.|..|.|:.|||..||:|:|.|:.||.:..||:  .:.:....:..||.
Zfish   273 SPKILFNQLCQKAPRFKGYQQQDSQELLHYLLDSMRVEETKRIKAGILK--AFNNPTEKTADEET 335

  Fly   458 RQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPV---AVEKPQPPQR 519
            :::.|.||.: |.::...:::|.|.|.||:.|::|.::|:..|.|:|:|||:   .:.||..|.|
Zfish   336 KRQVKAYGKE-GVKLNFVDRIFVGELTSTIMCEECEHISTVKEAFIDISLPIIEERISKPTNPAR 399

  Fly   520 --RKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKE 582
              :....:.||||...|                             |.||..|:
Zfish   400 LGKSGREQDSLTSHDDS-----------------------------LAAHSQAN----------- 424

  Fly   583 KERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTE 647
                |.::|.:.::.:|..:...:|. .|.:...|..::|..:|..|.
Zfish   425 ----RNSRRLSGQKLQSRHSSTSHDD-RGPDTVSSRQEEDLCVAGRGL----------------- 467

  Fly   648 DSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTP 712
             |:..:.|....||...:::.::|::..:.:....|..|...||.:...|..
Zfish   468 -SSYRTDTMGSQSDCSEKESNLQDSSNDADSEASESEWSPRIPSVSSHSSTS------------- 518

  Fly   713 EHMDKDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTA 777
               ||.|:                    :|:.|.|.:|.|:..:              |:|....
Zfish   519 ---DKTSI--------------------TTTLSTTTHNPSLKSN--------------PSSTPLP 546

  Fly   778 GL-SEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYS 841
            .: .::|.:|.:.||..::.|..:.:.|....:.:.|:..:|..:.:   |......:|...||:
Zfish   547 SIRPQQGGAVEQLVSAVSKLGLVHTSTDTLPISHSQEELSETRDRDR---QHHQGAFQVLCHSYT 608

  Fly   842 DWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQR----INGSDPKAKSVNTNA 902
            ..|.           ||||||||:.||::||:.|.||:.|::||.|    :..||.||:.|.|:|
Zfish   609 PSSK-----------ECSVQSCLHQFTSIELLMGNNKLLCENCTDRRQRQMKRSDKKAEKVYTSA 662

  Fly   903 TKQLLVSSPPAVLILHLKRF-QLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKL 966
            .||:|:|:.|.|:.|||||| |.|..  .||:.|.|.:|.|||:|.||.:..|||.:.:|    :
Zfish   663 RKQMLISALPPVVTLHLKRFHQAGMN--LRKVNRHVDFPLLLDLAPFCSATCKNLGSGER----V 721

  Fly   967 LYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKEK 1031
            ||:|||:|||||.|.||||.||||||
Zfish   722 LYSLYGIVEHSGSMRGGHYAAYVKVR--------------------------------------- 747

  Fly  1032 AREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVRAPPGKW 1096
                                         ||....|:::.|...:        ||.:  ||.|:|
Zfish   748 -----------------------------TPQRKPEQRRNQSGSR--------EACS--APQGQW 773

  Fly  1097 YYVSDSRVQEVSEDTALKAQAYLLFYERI 1125
            .||||:.||.|.|...|.:||||||||.:
Zfish   774 VYVSDTTVQTVPESRVLNSQAYLLFYEEL 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	20/50 (40%)
		Peptidase_C19	307..>512	CDD:271592	74/208 (36%)
		Peptidase_C19K	<849..1123	CDD:239132	101/278 (36%)
usp45	XP_005158432.1	UBP14	16..>329	CDD:227532	114/447 (26%)
		UBP12	<193..800	CDD:227847	230/827 (28%)
		Peptidase_C19	193..>389	CDD:351799	74/205 (36%)
		Peptidase_C19K	<606..800	CDD:239132	104/288 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	232	1.000	Domainoid score	I2351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	276	1.000	Inparanoid score	I2923
OMA	1	1.010	-	-		QHG47475
OrthoDB	1	1.010	-	-		D278083at2759
OrthoFinder	1	1.000	-	-		FOG0002415
OrthoInspector	1	1.000	-	-		otm25379
orthoMCL	1	0.900	-	-		OOG6_103128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5847
SonicParanoid	1	1.000	-	-		X2117
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910