DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and usp4

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_002662556.2	Gene:	usp4 / 449927	ZFINID:	ZDB-GENE-041008-187	Length:	1009	Species:	Danio rerio

Alignment Length:	949	Identity:	215/949 - (22%)
Similarity:	346/949 - (36%)	Gaps:	283/949 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 SSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQY--SATTNGN-TGNKRLLTLETPRIEN 299
            :|||...:     |:|||..|.:.|.|...|.:.....|  :.:|:|| .|:....:......|:
Zfish   253 TSRNYTTS-----PKPSSNSSATISSTITNGDSNSNSGYMLNNSTSGNRLGSYNSYSSSYSYRES 312

  Fly   300 ERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMI 364
            ...|.:.||:|||||||.|:.:|||:.||           |..|:.|       :|:.:.|:..
Zfish   313 AAQPGLCGLSNLGNTCFMNSALQCLSNTP-----------PLTEYFL-------EDRYEAEINR- 358

  Fly   365 KGTLSSWGGLTAALANALEELQAGGSVF-TPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVR 428
            :..|...|.:..|.|:.::::....|.: .||....::....|||:|..|.|:.|||..||:.:
Zfish   359 ENPLGMRGEIAEAYADLVKQMWLSRSSYVAPRTFKTQVGRFAPQFSGYQQQDSQELLAFLLDGL- 422

  Fly   429 NEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQ--AGDRILRPEQVFRGFLVSTLTCQD 491
            :|||.|.::.....|    :|.....:|:..| :.:.|.  ..|.|:  ..:|.|...|||.|.:
Zfish   423 HEDLNRVKKKPYLAL----RDAEGRPDEIVAK-EAWANHRLRNDSII--VDIFHGLFKSTLVCPE 480

  Fly   492 CHNVSSRHEYFLDMSLPVAVEK------------PQ--PPQRRKPSPEL-SLTSSSSSVTPSTGQ 541
            |..||...:.|..::||:.::|            ||  ..|.|...|:: ::....|::...:|.
Zfish   481 CSKVSVTFDPFCYLTLPLPMKKDRTMEVYLVRTDPQFRAMQFRVVVPKMGAVADLCSALAKLSGV 545

  Fly   542 PT--------INTKF-----TDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAA 593
            |:        .|.:|     .|..:|........|::           ..::::.||........
Zfish   546 PSENMVVADVYNHRFHKIYKRDDGLNQIMEKDDIFVY-----------EVLEEDSERMNLPVYFR 599

  Fly   594 KKRQKSSLNLNGNDSGN---GNELAESVDQDDAS--------LASLGAGDGQANDGLEQTNGQ-T 646
            ::..|.|    |..||.   |..|..:|.:.:.:        |..:|.       .::::.|. |
Zfish   600 ERHAKHS----GGSSGTMLFGQPLLITVPRLNLTVDTLYERVLERIGR-------YVKRSQGTIT 653

  Fly   647 EDSTTSSVTTSEHSD-----ADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGE 706
            |...::|.|:|..|.     |.|..:   .|.....::..|..||.:|.|.. .:.:|....|..
Zfish   654 ESRASASATSSSSSQSPECLASVSSH---GTGLSGCSSPVSDGASCSAGSNG-SNHSGTCNGPNG 714

  Fly   707 KRDDTPEHMDKDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAP 771
            ..|...|.||.....|.||      |.:.|......|....|.|:|      .|.|......|..
Zfish   715 VCDGDEEAMDHQESPEPEN------SHSDTVDGEEDSEPENGPNSS------GGKSFNSRPKLFS 767

  Fly   772 ASLV----TAGLSEK--GASVIRQVSVGAEQGASNGTEDADGEAKAI---EQPEKTPSQAQAMAQ 827
            .|:|    ||.:|..  ..::::..:      .|....|.|.:.|.:   :|..:...:.::|..
Zfish   768 FSMVNSYGTANISSLPFDGNLLKLTT------HSTVAIDWDSDTKRLCYDDQEAEAYDKHESMLH 826

  Fly   828 AQARTKRVRTQSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSD 892
            ||.:            .||:|           ::.|:..||.:|.:...:...|.:|.:
Zfish   827 AQKK------------KTTVA-----------LRECIELFTTMETLGEHDPWYCPTCKK------ 862

  Fly   893 PKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYP-NLLDIAAF-CGSKVKN 955
                  :..|||:..:.|.|.:|::|||||... ||...||...|.:| ..|:::.| |
Zfish   863 ------HQQATKKFDLWSLPRILVVHLKRFSYN-RCWRDKLDTVVDFPIRDLNMSEFVC------ 914

  Fly   956 LPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQL 1020
                |.|....:|.|..|..|.|||.|||||||.|                  :||:
Zfish   915 ----DPKADPYIYDLIAVSNHYGGMGGGHYTAYGK------------------NKAD-------- 949

  Fly  1021 KKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEE 1085

Zfish   950 ----------------------------------------------------------------- 949

  Fly  1086 AANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                    |||||..||.|...:||..:...||:|||:|
Zfish   950 --------GKWYYFDDSSVSAATEDQIVTKAAYVLFYQR 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	61/207 (29%)
		Peptidase_C19K	<849..1123	CDD:239132	59/275 (21%)
usp4	XP_002662556.2	UBP12	8..981	CDD:227847	215/949 (23%)
		DUSP	44..141	CDD:197831
		Ubiquitin_3	155..242	CDD:291502
		Peptidase_C19	319..>507	CDD:271592	62/214 (29%)
		USP7_C2	526..>606	CDD:291217	12/90 (13%)
		Peptidase_C19R	<834..979	CDD:239139	60/277 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900