DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp8

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster

Alignment Length:	962	Identity:	176/962 - (18%)
Similarity:	296/962 - (30%)	Gaps:	354/962 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 LLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAAL-------ANALEELQA 387
            ||:..::|....||:.|         .||.||..|  |...:..:..|:       ::.....|.
  Fly    33 LLNTARKLYMTAEEYRL---------DGDEELAYI--TYMKYFNMLTAIHKKSDYPSHKTTVRQM 86

  Fly   388 GGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNS 452
            .|...:.|::.|                   .|.:::.|:|:    ||.:        :.|....
  Fly    87 LGDTESNRRIMD-------------------TLEEIINSLRH----RYAQ--------QHQAPEP 120

  Fly   453 VSEEMRQKCKIYGNQAG--DRILRPEQVFRGFLVSTLTCQDCHN------------------VSS 497
            ::.::     :...:||  ..|.:|.|..|   :..:||||.:.                  .:|
  Fly   121 IAPDL-----VSNGRAGVDSPITQPTQYAR---LGLITCQDLYRRMQEKSVLVMDCRPSADYEAS 177

  Fly   498 RHEYFLDMSLPVAVEKPQPPQRR---KPSPELSLTSSSSSVTPST---------GQPTINT---- 546
            ...|:...::|..:..|.....|   :.|.....:.:|.||..|.         .||..||
  Fly   178 HLTYYCAFNVPEELITPGMSAGRLQARLSSSAKASWASRSVKDSVVLMDWNTKDAQPATNTAIST 242

  Fly   547 -----KFTDGSVNFTA------SSPSFFLHAHEAASLGPS------------------------- 575
                 |..|..|.:.|      ....:|:..:......||
  Fly   243 LLDILKNWDPDVTYRAPIQIVEGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETIDDIEYPSIHDI 307

  Fly   576 --KSQVKKEKERQRKAKRAAKKRQKSSLNLNG---------------NDSGNGNELAESVDQDDA 623
              |..:..:..|.|.....|.|...:.:|..|               .|.....:.||..|:...
  Fly   308 TMKEDISAKDFRPRPDFNRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLE 372

  Fly   624 SLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAA-------------- 674
            ..:.:........|||..|..| |.........|:..|..||:|.:.:..:
  Fly   373 KASKMWKRQAAEGDGLNATEDQ-ELHFRILQLESKAQDYIVENNRLREELSRIQELHNVTQQLSQ 436

  Fly   675 ---PSTNNVPSS--------------------TASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMD 716
               .:|.|:.|.                    ..::...:|.:..|...:.||...|:....|:.
  Fly   437 KEVEATRNIESKIRERQRLDEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVV 501

  Fly   717 KDSLEE-----DENDSGIATSPA----------PTATNSSTSTSATGNNNSV----AGSGLSG-- 760
            .||||.     .:.|..||.:.|          |...|...::....:.:.|    .|.||:|
  Fly   502 SDSLESLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNVERTSQRVRDFSPVIGQNVGRGLTGLK 566

  Fly   761 -------------------------SSGALEDPLAPASLVTAGLSEKGASVIRQV---------- 790
                                     .|...::.::.::.....:.|:.|::|:::
  Fly   567 NLGNTCYMNSILQCLSNTPQLTEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNGQYKCVAS 631

  Fly   791 -----SVGAEQGASNGTEDADG----------------------EAKAIEQPEKT---------- 818
                 .||..|....|.:..|.                      :.:.|...||.
  Fly   632 RDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKES 696

  Fly   819 ------PSQAQAMAQAQARTKRVRT-QSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQ 876
                  ..|.::..:..|..|...| :|:|:.|..:.|    ....|.:..|::.:.:.|.:.|.
  Fly   697 MILHLFYGQMKSTVKCVACHKESATYESFSNLSLELPP----NSNVCQLNQCMDMYFSGERIHGW 757

  Fly   877 NKVGCDSC-TQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYP 940
            |   |.|| |:|             :|.|:|.:|..|.||::|||||...|       :...||.
  Fly   758 N---CPSCKTKR-------------DAIKKLDISKLPPVLVVHLKRFYADP-------SNSGSYM 799

  Fly   941 NLLDIAAFCGSKVKNL---PNIDRKQKKLL----YALYGVVEHSGGMYGGHYTAYVKVRPKVAPG 998
            ...:...|   .::||   |.|.|.:.:.:    |.||.|..|.|.|.||||||:.    |.|..
  Fly   800 KKQNYLRF---PLENLDMNPYIARAESRAVTPKTYQLYAVSNHYGTMEGGHYTAFC----KSANY 857

  Fly   999 DKRWKFLPHGSKAELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSS 1050
            .|.:||            |||:                :..||.|:..|:::
  Fly   858 GKWFKF------------DDQV----------------VSALDSSNVVSSAA 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	36/208 (17%)
		Peptidase_C19K	<849..1123	CDD:239132	57/210 (27%)
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108	22/113 (19%)
		RHOD	148..278	CDD:294087	23/129 (18%)
		UCH	562..886	CDD:278850	78/382 (20%)
		Peptidase_C19R	564..887	CDD:239139	77/380 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456856
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930