DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp11

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_001008861.2	Gene:	Usp11 / 408217	RGDID:	1303052	Length:	921	Species:	Rattus norvegicus

Alignment Length:	901	Identity:	206/901 - (22%)
Similarity:	293/901 - (32%)	Gaps:	345/901 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 PRVRGLTNLGNTCFFNAVMQCLAQTPFLLS------VLKELSEPGEEFILPGGTFTIKDKGDIE- 360
            |.:.||||||||||.|:.:|||:..|.|..      .|:||:     |..|.|.     ||::.
  Rat   254 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNRYLEELN-----FRNPLGM-----KGELAE 308

  Fly   361 --LPMIKGTLSSWGGLTAALANALEELQAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQL 423
              ..::|.|   |.|...::              .|....:::.....||.|..|||:.|||..|
  Rat   309 AYADLVKQT---WSGYHRSI--------------VPNVFKNKVGHFASQFLGYQQHDSQELLSFL 356

  Fly   424 LESVRNEDLKRYQR----VILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLV 484
            |:.: :|||.|.::    .:....|..|.:   |::|..|..|    :..|.::  ...|.|...
  Rat   357 LDGL-HEDLNRVKKKEYVELCNGAGRPDLE---VAQEAWQNHK----RRNDSVI--VDTFHGLFK 411

  Fly   485 STLTCQDCHNVSSRHEYFLDMSLPVAVEK---------PQPPQRRKPSPELSLTSSSSSVTPSTG 540
            |||.|.||.|||...:.|..:|:|:.|..         |..| ||||       .....|.|..|
  Rat   412 STLVCPDCGNVSVTFDPFCYLSVPLPVCSRRVLEVFFVPMDP-RRKP-------EQHRVVVPKKG 468

  Fly   541 QPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNG 605
                           ..|.....|..|  .|:.|.|..|     ....:.|..|..|..
  Rat   469 ---------------NISDLCVALSTH--TSVAPDKMIV-----ADVFSHRFYKLYQLE------ 505

  Fly   606 NDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVE 670
                  :.|:..:|:||..:.       :....:|...|..:|..             |...|.|
  Rat   506 ------DPLSGILDRDDIFVY-------EVTGRIEPVEGSRDDIV-------------VPVYLRE 544

  Fly   671 DTAAPSTNN---------------VPSSTAS---------------LTAPSKTYMDSNGNAQPPG 705
            .|.:...||               ||....|               :|.|  |..|.:|:.:  |
  Rat   545 RTPSRDYNNSYYGLILFGHPLLVSVPRDRFSWEGLYNILMYRLSRYVTKP--TSDDDDGDEK--G 605

  Fly   706 EKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLA 770
            ::.:|.....|..|.||.|..||      ||   .:..|..:....:...||::|...:|.|...
  Rat   606 DENEDEDVEDDSSSEEEKEEMSG------PT---DNDGTQESEQEQAGTSSGVTGRCPSLLDNSL 661

  Fly   771 PASLVTAGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRV 835
            ..|........|....::.|:       ||||.|.          ..:|.:||
  Rat   662 HTSQWPPRRRRKQLFTLQTVN-------SNGTSDR----------TTSPEEAQ------------ 697

  Fly   836 RTQSY--SDWSTTIAPRYQCE---DG----EC----------SVQSCLNNFTAVELMTGQNKVGC 881
             ||.|  .||...:..||..|   :|    :|          .::.|:..||.||.:..:|...|
  Rat   698 -TQPYIAMDWEPEMKRRYYDEVEAEGYVKHDCVGYMLKKNPVQLKECIKLFTTVETLEKENPWYC 761

  Fly   882 DSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRP-----VSYP- 940
            .||.|            :..|||:|.:...|.|||:|||||.      |.|.:|.     |.:|
  Rat   762 SSCKQ------------HQLATKKLDLWMLPEVLIIHLKRFS------FSKFSREKLDTLVQFPI 808

  Fly   941 NLLDIAAFCGSKVKN--LPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWK 1003
            ..||.:.|. .|.||  .|::.:      |.|..|..|.|||..||||.:.
  Rat   809 RDLDFSEFV-IKPKNESAPDLYK------YDLIAVSNHYGGMRDGHYTTFA-------------- 852

  Fly  1004 FLPHGSKAELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEE 1068
                                                       .|..|
  Rat   853 -------------------------------------------CNKDS----------------- 857

  Fly  1069 QQTQQAQQPQQPQQLEEAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                                     |:|:|..|:.|..|:|:......||:|||:|
  Rat   858 -------------------------GQWHYFDDNSVSPVNENQIESKAAYVLFYQR 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	65/217 (30%)
		Peptidase_C19K	<849..1123	CDD:239132	64/298 (21%)
Usp11	NP_001008861.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		UBP12	23..888	CDD:227847	205/899 (23%)
		DUSP	44..136	CDD:197831
		Ubiquitin_3	154..233	CDD:291502
		Peptidase_C19	<254..>370	CDD:271592	45/143 (31%)
		Peptidase_C19	258..>437	CDD:271592	65/215 (30%)
		USP7_C2	428..>541	CDD:291217	31/174 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..697		31/134 (23%)
		Peptidase_C19R	<736..887	CDD:239139	59/274 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	893..921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810