DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp2

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	129/573 - (22%)
Similarity:	207/573 - (36%)	Gaps:	143/573 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 ECDMKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSF 218
            |||..:.:|              .|.|..|:..||:..|.:.......:::..:| :......|.
  Fly   488 ECDSVVLTN--------------KASKDATTAATPTVATATATHTPATSSVSTVT-VTAAAPNSA 537

  Fly   219 DDSSSR--------GSLAAAGGGGGVGSSRNRQVAIPMPPP-----EPSSGLSTSDSLTSVPGMA 270
            .||.||        .:||.:|.|   .||..|.|..||.|.     :..||.|.|..     |.:
  Fly   538 SDSVSRSLARSPISSTLARSGTG---SSSTARSVLPPMTPTSSRYWDRDSGTSRSSI-----GTS 594

  Fly   271 KRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLK 335
            ..::..|...|.:.|.|   |..:.|  :|:...:.||.|:|||||.|:|:|||:.|..|...|:
  Fly   595 SALNSSSLKHNSDDGYK---TASSSR--DEKSEGLCGLRNIGNTCFMNSVIQCLSHTQELTRFLR 654

  Fly   336 ELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEEL-QAGGSVFTPRKLFD 399
              |..|..      :.:.||:                .:....|..::|: .|.....||.:|..
  Fly   655 --SHHGSR------SLSTKDQ----------------QILHEFAKLIQEMWTANVHTVTPMELKR 695

  Fly   400 RLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKI- 463
            ....|...::..:|.||.|.||..|:|:.:          ..|.|.|.:.:| :.:.:....|.
  Fly   696 AFSTKHRMYSDYNQQDAQEFLRFFLDSLHS----------ALNSGVKGETLN-IDDNLSDNKKAD 749

  Fly   464 -----YGNQAGDRILRPEQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPS 523
                 |.......:   ..:|.|.|.|||.|..|.|.|...:.|.|:|:|
  Fly   750 LTWEWYTRHENSLV---RDLFVGQLKSTLKCTTCGNTSVTFDPFWDLSVP--------------- 796

  Fly   524 PELSLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRK 588
                |.|||.....:.....|..:..||....|.:                      |.|.|::.
  Fly   797 ----LPSSSRCKLEACLDLFIREEVLDGDEMPTCA----------------------KCKTRRKC 835

  Fly   589 AKRAAKKRQKSSL--NLNGNDSGNGNELAESVD--QDDASLASLGAGDGQANDGLEQ-----TNG 644
            .|....:|....|  :|........::|:..|:  ..|:.| ::|:....:|..:..     :|.
  Fly   836 TKSFTIQRFPKYLVIHLKRFSETRWSKLSNIVEFPTSDSEL-NMGSYGANSNSNVHYSLYAISNH 899

  Fly   645 QTEDSTTSSVTTSEHSDA----DVEDNLVEDTAAPSTNNVPSSTASLTAPSKT 693
            ....:....|...:|..:    :..||:|.|  |.|.|::.||:|.:....:|
  Fly   900 MGSTAGGHYVALCKHPVSRKWHEFNDNIVSD--ALSENHLVSSSAYILFYERT 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	3/4 (75%)
		Peptidase_C19	307..>512	CDD:271592	55/211 (26%)
		Peptidase_C19K	<849..1123	CDD:239132
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	89/404 (22%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	89/403 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456912
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930