Protein Alignment Usp16-45 and Usp49

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001129942.1
• Gene: Usp49 / 316211
• RGDID: 1310513
• Length: 685
• Species: Rattus norvegicus
• Alignment Length: 1132
• Identity: 197/1132 - (17%)
• Similarity: 293/1132 - (25%)
• Gaps: 561/1132 - (49%)

  Fly    45 CQHIKKAVDAARLRRLLKSTGLL----YECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFD 105
            |:|:      .|| ||.:...:|    :.|.:|             ..:|.|
  Rat     4 CKHV------GRL-RLAQDHSILNPQKWCCLEC-------------ATTESA------------- 35

  Fly   106 NTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYEC-----------DMKI 159
               |.||||....|||....|||:|::   ...|.|||..|...::||.|           |:|:
  Rat    36 ---WACLKCSHVACGRYIEDHALKHFE---ETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKL 94

  Fly   160 CSNLRKNLLECVELVKKLAQKPPT-------ST-----VTPSTPTISYIEEKLKAALEHLTPIVP 212
               ||.:||    .|:...|..|.       ||     |.|...|.....:.|.|.......::.
  Rat    95 ---LRSSLL----AVRGQKQDLPARRGRTLRSTAAGEDVVPPQRTPQGQPQMLTALWYRRQRLLA 152

  Fly   213 MTGGSFDDSSSRGSL--------AAAGGGGGVGSSRNRQV------AIPMPPPEPSSGLSTSDSL 263
            .|...:.:.||||..        .|..........|.|:|      .:...||..|:.|     |
  Rat   153 KTLRLWFEKSSRGRAQLEQRRQEEALERKKEAARQRRREVKRRLLEELASAPPRKSARL-----L 212

  Fly   264 TSVPG-MAKRIDQYSATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQT 327
            ...|| :|.|    .||.  .|..:.......||.:....|.|.||.||||||:.|:::|.|:..
  Rat   213 LHAPGPVAVR----PATL--ATSRRMSAAALKPRRQLAVAPGVTGLRNLGNTCYMNSILQVLSHL 271

  Fly   328 PFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLT----------------- 375
            .........|.....|.:.|..|     .|..::|. :...|:..|.:
  Rat   272 QKFRECFLNLDPSTSEHLFPQAT-----NGKAQIPS-RPASSTAAGFSVRSDRAQGFEPQGFCWS 330

  Fly   376 --AALANALEELQ------------------------AGGSVFTPRKLFDRLCVKCPQFTGGDQH 414
              |:::.:||.:|                        ...::.:|..:...:....|.|.|.||.
  Rat   331 SGASISRSLELIQNKEPSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQ 395

  Fly   415 DAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEE--MRQKCKIYGNQAGDRILRPEQ 477
            ||.|.|.:||..|:.|         |::.|...:.:...|:.  .:|..|:...
  Rat   396 DAQEFLCELLHKVQQE---------LESEGSTRRILIPFSQRKLTKQVLKVVNT----------- 440

  Fly   478 VFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQP 542
            :|.|.|:|.:||..|:..|:..|.|.|:||
  Rat   441 IFHGQLLSQVTCVSCNYKSNTIEPFWDLSL----------------------------------- 470

  Fly   543 TINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGND 607
                                                                             
  Rat   471 ----------------------------------------------------------------- 470

  Fly   608 SGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDT 672
                                                                             
  Rat   471 ----------------------------------------------------------------- 470

  Fly   673 AAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTA 737
                                                                             
  Rat   471 ----------------------------------------------------------------- 470

  Fly   738 TNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGASNGT 802
                                                                             
  Rat   471 ----------------------------------------------------------------- 470

  Fly   803 EDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQC-EDG-------ECS 859
                      |.||                                 ||.| |.|       ||.
  Rat   471 ----------EFPE---------------------------------RYHCVEKGFVPLNQTECL 492

  Fly   860 VQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQL 924
            :...|..||..|.:.|: ...||.|..:...|:|| ..|.:.|.|||::...|.||.||||||:.
  Rat   493 LTEMLAKFTETEALEGR-IYACDQCNSKRRKSNPK-PLVLSEARKQLMIYRLPQVLRLHLKRFRW 555

  Fly   925 GPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYGVVEHSGGMYG-GHYTAY 988
            ..|....|:...|.:..:|.:..:|...:  |.::|:  ....|.|..||.|.|..:| ||||||
  Rat   556 SGRNHREKIGVHVVFDQVLTMEPYCCGDM--LSSLDK--DTFAYDLSAVVMHHGKGFGSGHYTAY 616

  Fly   989 VKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKE---------------KAREQHLK 1038
            ..        :....|..|.:.::||     :..:||:...:               |..|.||:
  Rat   617 CY--------NTEGGFWVHCNDSKLD-----VCSVEEVCKTQAYILFYTRRTVQGSAKLSEPHLR 668

  Fly  1039 VLDDSDDFSNSSSNSSTSDESQTPATP 1065
                      :..:||:.|:.:|...|
  Rat   669 ----------AQVHSSSKDDRRTYTFP 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	21/61 (34%)
		UBP12	<307..990	CDD:227847	110/736 (15%)
		Peptidase_C19	307..>512	CDD:470612	55/249 (22%)
		Peptidase_C19K	<849..1123	CDD:239132	67/241 (28%)
Usp49	NP_001129942.1	zf-UBP	26..87	CDD:460464	24/92 (26%)
		UCH	250..651	CDD:425685	116/783 (15%)