DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp31

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_038934149.1	Gene:	Usp31 / 308959	RGDID:	1308183	Length:	1349	Species:	Rattus norvegicus

Alignment Length:	1015	Identity:	209/1015 - (20%)
Similarity:	305/1015 - (30%)	Gaps:	364/1015 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 PIVPMTGG-----SFDDSSSR-GSLAAAGGGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVP 267
            |..|:..|     ||.....| |....:||.||.|         |..|..|||..|....::.|
  Rat    11 PGPPVAAGGKEKRSFSKRLFRSGRAGGSGGAGGPG---------PAAPSSPSSARSVGSFMSRV- 65

  Fly   268 GMAKRIDQYSATTNGNTGNKR-----------------------LLTLETPRIENERLPRVRGLT 309
              .|.:...|..::......|                       ..:...|...:|.:|.|.||.
  Rat    66 --LKTLSTLSHLSSEGAAPDRGGLRSCFPPGPASAPTPPPCPPPPASPAPPACASEPVPGVAGLR 128

  Fly   310 NLGNTCFFNAVMQCLAQTPFLLSVL------KELSEPGEEFILPGGTFTIKDKGDIELPMIKGTL 368
            |.|||||.||.:|||:.|......|      ....||..|...|.|      :|    |..:|.:
  Rat   129 NHGNTCFMNATLQCLSNTELFAEYLALGQYRAGRPEPEPEPEQPAG------RG----PHGQGEV 183

  Fly   369 SSWGGLTAALANALEELQAGGSVFTPRKLFDRLCV---KCPQFTGGDQHDAHELLRQLLESVRNE 430
            :.   ..|.|..||..|:     :||:...|...:   ...|:.|..||||.|.|..||:.| :|
  Rat   184 TE---QLAHLVRALWTLE-----YTPQHSRDFKSIVSKNALQYRGNSQHDAQEFLLWLLDRV-HE 239

  Fly   431 DLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRP-------------------- 475
            ||....:                             |:|...|:|
  Rat   240 DLNHAVK-----------------------------QSGQPPLKPPSETDMMPEGPSFPVCSTFV 275

  Fly   476 EQVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTG 540
            :::|:....|:|||..|...|:..:.||.:|||:    |.|..|
  Rat   276 QELFQAQYRSSLTCPHCQKQSNTFDPFLCISLPI----PLPHTR--------------------- 315

  Fly   541 QPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKER-QRKAKRAAKKRQKSSLNLN 604
             |...|....|..:          |........|....|.:.:|. ..:.|....:...:.:..:
  Rat   316 -PLYVTVVYQGKCS----------HCMRIGVAVPLSGTVARLREAVSMETKIPTDQIVLTEMYYD 369

  Fly   605 G-NDSGNGNELAESVDQDDASLA----SLGAGDG-------QANDGLEQTNGQTEDSTTSSVTTS 657
            | :.|.:..:..|:|.:.|...|    .:...:|       ..|:.|.......:....||.|.:
  Rat   370 GFHRSFSDTDDLETVHESDCIFAFETPEIFRPEGILSQRGIHLNNNLNHLKFGLDHHRLSSSTPT 434

  Fly   658 EHSDADVEDNLVEDTAAPSTNNVPSSTAS----LTAPSKTYMDSNGNAQPPGEKRDDTP--EHMD 716
            ......|:              :||..||    |...::......|       ||...|  .|::
  Rat   435 AAKQGRVD--------------LPSRVASDKIVLLVCNRACTGQQG-------KRFGLPFVLHLE 478

  Fly   717 K----DSLEEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTA 777
            |    |.|:::..:. :.....||.:......|.    ..|:..|::......|.||...: |..
  Rat   479 KTVAWDLLQKEILEK-MKYFLRPTVSVQVCPFSL----RVVSVVGITYLLPQEEQPLCHPT-VER 537

  Fly   778 GLSEKGASVIRQVSVGAEQGASNGTED---ADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQS 839
            .|...|......|.:..|.  ...|:|   .:.|.:.|...|....|.:...|.|.
  Rat   538 ALKSCGPGGTAHVKLVVEW--DKETKDFLFVNTEDEYIPDAESVRLQKEQHHQPQT--------- 591

  Fly   840 YSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATK 904
                              |::..|...:|..|.:...:...|..|.|...||            .
  Rat   592 ------------------CTLSQCFQLYTKEERLAPDDAWRCPHCKQLQQGS------------I 626

  Fly   905 QLLVSSPPAVLILHLKRF-QLGPRCIFRKLTRPVSYP-NLLDIAAFCGSKVK---NLPN------ 958
            .|.:.:.|.|||:||||| |.|.|.:  ||...|.:| ..||:......:.:   :||:
  Rat   627 TLSLWTLPDVLIIHLKRFRQEGDRRM--KLQNMVKFPLTGLDMTPHVVKRSQSSWSLPSHWSPWR 689

  Fly   959 ----IDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQ 1019
                :.|..:..:|.||.|..|.|.|.|||||||.|
  Rat   690 RPYGLGRDPEDYIYDLYAVCNHHGTMQGGHYTAYCK----------------------------- 725

  Fly  1020 LKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLE 1084
                                        ||..
  Rat   726 ----------------------------NSVD--------------------------------- 729

  Fly  1085 EAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                     |.||...||.||::|||......||:|||:|
  Rat   730 ---------GLWYCFDDSDVQQLSEDEVCTQTAYILFYQR 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	61/233 (26%)
		Peptidase_C19K	<849..1123	CDD:239132	62/288 (22%)
Usp31	XP_038934149.1	UBP12	<123..762	CDD:227847	184/891 (21%)
Usp31	XP_038934149.1	PHA03307	959..>1211	CDD:223039
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900