DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp32

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_038941969.1	Gene:	Usp32 / 303394	RGDID:	1306657	Length:	1683	Species:	Rattus norvegicus

Alignment Length:	1008	Identity:	204/1008 - (20%)
Similarity:	324/1008 - (32%)	Gaps:	341/1008 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 RIENERLPRVR---GLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPG-GTFTIKDK 356
            :|:..::|..:   ||:|||||||.|:.:||::.|           :|..::.:.| ..:.:...
  Rat   800 KIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNT-----------QPLTQYFISGRHLYELNRT 853

  Fly   357 GDIELPMIKGTLSSWGGLTAALANALEELQAGGSV-FTPRKLFDRLCVKCPQFTGGDQHDAHELL 420
            ..|.:   ||.::...|      :.::||.:|... ..|.||...:....|:|.|..|.|:.|||
  Rat   854 NPIGM---KGHMAKCYG------DLVQELWSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELL 909

  Fly   421 RQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQ-----VFR 480
            ..||:.: :|||.|........|  ||.|.....|        ...:|.|..||..:     :|.
  Rat   910 AFLLDGL-HEDLNRVHEKPYVEL--KDSDGRPDWE--------VAAEAWDNHLRRNRSIVVDLFH 963

  Fly   481 GFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLT-SSSSSVTPSTGQPTI 544
            |.|.|.:.|:.|.::|.|.:.|..:|||:.::...         .|.:| ......||......:
  Rat   964 GQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYM---------HLEITVIKLDGTTPIRYGLRL 1019

  Fly   545 N--TKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGND 607
            |  .|:|.             |....:...|....|:...:......|...:..||..|:::|
  Rat  1020 NMDEKYTG-------------LKKQLSDLCGLKSEQILFAEVHSSNIKNFPQDNQKVRLSVSG-- 1069

  Fly   608 SGNGNELAESVDQDDASLAS----LGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNL 668
                            .|.:    :.|....|...: ||:..:..||....|.:.:.|
  Rat  1070 ----------------FLCAFEIPIPASPVSACSPI-QTDCSSSPSTNGLFTVTTNGD------- 1110

  Fly   669 VEDTAAPSTNNVPSSTASLTAPSKTYMDS-----NGNAQPPGEKRDDTPEHMDKDSLEEDENDSG 728
                 .|....:|:...:...|..|..::     ||:..|                |.:|.....
  Rat  1111 -----LPRPIFIPNGMPNTVVPCGTEKNATNGIVNGHMPP----------------LPDDPFTGY 1154

  Fly   729 IATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGA---SVIRQV 790
            |...............|:..|..|:.|..|          :.|.::.|.......|   .|.|..
  Rat  1155 IIAVHRKMMRTELYFLSSQKNRPSLFGMPL----------IVPCTVHTRKKDLYDAVWIQVSRLA 1209

  Fly   791 SVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYS-------------- 841
            |....|.|||..:|.|                .:|......|.||..:..:
  Rat  1210 SPLPPQEASNHAQDCD----------------DSMGYQYPFTLRVVQKDGNSCAWCPWYRFCRGC 1258

  Fly   842 ------------------DWS-TTIAPRYQ------CEDGE------------CSVQSCLNNFTA 869
                              ||. |.:..|||      .|:.|            .::.|||..||:
  Rat  1259 KIDCGEDRAFIGNACIAVDWDPTALHLRYQTSQERVVEEHESVEQSRRAQAEPINLDSCLRAFTS 1323

  Fly   870 VELMTGQNKV-GCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQ-LGPRCIFRK 932
            .|.: |:|:: .|..|            ..:..|||:|.:...|.:||:|||||| :..|.|  |
  Rat  1324 EEEL-GENEMYYCSKC------------KTHCLATKKLDLWRLPPILIIHLKRFQFVNGRWI--K 1373

  Fly   933 LTRPVSYP-NLLDIAAF--------C--------GSKVKNLPNIDRKQKKLLYALYGVVEHSGG- 979
            ..:.|.:| ...|.:||        |        |..|..||......||:      .|::..|
  Rat  1374 SQKIVKFPRESFDPSAFLVPRDPTLCQHKPLTPQGDDVSELPIPAGDVKKV------DVQNPAGE 1432

  Fly   980 ------MYGGHYTAYVKVRPKVAPGDKR---------WKFLPHGSKAELDQDDDQLKKLEELLAK 1029
                  ......:|.:...||.:|...|         ....|:.|...|.::..:| :|.::.:|
  Rat  1433 EDVLLSKSPSSLSANITSSPKGSPSSSRKSGASCPSSKNSSPNSSPRTLGRNKGRL-RLPQIGSK 1496

  Fly  1030 EKAREQHLKVLDDSDDFSNSSSNSSTSDE---------------------SQTP-ATPLEEQQT- 1071
            .|              .|:|..|...|.|                     ||.. .|||:.:.|
  Rat  1497 NK--------------LSSSKENLDASRENGAGQICELADTLNRGHVLGGSQPELVTPLDHEITL 1547

  Fly  1072 ---------------------QQAQQPQQPQQLEEAAN------------------------VRA 1091
                                 ..:::.....|.|:..:                        .:.
  Rat  1548 ANGFLYEHETCGNGYSNGQLGNHSEEDSTDDQREDTHSKPIYNLYAISCHSGILGGGHYVTYAKN 1612

  Fly  1092 PPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
            |..|||..:||..:|:..|......||:||||:
  Rat  1613 PNCKWYCYNDSSCKELHPDEIDTDSAYILFYEQ 1645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	60/211 (28%)
		Peptidase_C19K	<849..1123	CDD:239132	82/394 (21%)
Usp32	XP_038941969.1	FRQ1	254..404	CDD:227455
		UBP12	583..1395	CDD:227847	156/735 (21%)
		UCH	<1314..1643	CDD:395355	76/364 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900