DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp11

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_663603.3	Gene:	Usp11 / 236733	MGIID:	2384312	Length:	921	Species:	Mus musculus

Alignment Length:	837	Identity:	204/837 - (24%)
Similarity:	294/837 - (35%)	Gaps:	255/837 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 PRVRGLTNLGNTCFFNAVMQCLAQTPFLLS------VLKELSEPGEEFILPGGTFTIKDKGDIE- 360
            |.:.||||||||||.|:.:|||:..|.|..      .|:||:     |..|.|.     ||::.
Mouse   254 PGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNRYLEELN-----FRNPLGM-----KGELAE 308

  Fly   361 --LPMIKGTLSSWGGLTAALANALEELQAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQL 423
              ..::|.|   |.|...::              .|....:::.....||.|..|||:.|||..|
Mouse   309 AYADLVKQT---WSGYHRSI--------------VPNVFKNKVGHFASQFLGYQQHDSQELLSFL 356

  Fly   424 LESVRNEDLKRYQR----VILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLV 484
            |:.: :|||.|.::    .:....|..|.:   |::|..|..|    :..|.::  ...|.|...
Mouse   357 LDGL-HEDLNRVKKKEYVELCNGAGRPDLE---VAQEAWQNHK----RRNDSVI--VDTFHGLFK 411

  Fly   485 STLTCQDCHNVSSRHEYFLDMSLPVAVEK---------PQPPQRRKPSPELSLTSSSSSVTPSTG 540
            |||.|.||.|||...:.|..:|:|:.|..         |..| ||||       .....|.|..|
Mouse   412 STLVCPDCGNVSVTFDPFCYLSVPLPVCSRRVLEVFFVPMDP-RRKP-------EQHRVVVPKKG 468

  Fly   541 QPTINTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNG 605
                           ..|.....|..|  .|:.|.|..|     ....:.|..|..|..
Mouse   469 ---------------NISDLCVALSTH--TSVAPDKMIV-----ADVFSHRFYKLYQLE------ 505

  Fly   606 NDSGNGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVE 670
                  :.|:..:|:||..:.       :....:|...|..:|..             |...|.|
Mouse   506 ------DPLSGILDRDDIFVY-------EVTGRIEPVEGSRDDIV-------------VPVYLRE 544

  Fly   671 DTAAPSTNN---------------VPSSTAS-------LTAPSKTYMDSNGNAQPPGEKRDDTPE 713
            .|.:...||               ||....|       |......|:..      |....||..|
Mouse   545 RTPSRDYNNSYYGLILFGHPLLVSVPRDRFSWEGLYNILMYRLSRYVTK------PTSDEDDGDE 603

  Fly   714 HMDKDSLEEDENDSGIATS----PAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASL 774
            .:|:|..|:.|:||.....    .|||..:   .|.......:...||::....:|.|....||.
Mouse   604 KVDEDEDEDVEDDSSSEEEKEEMSAPTVND---GTREAEQEQAGTSSGVTERCPSLLDNSLRASQ 665

  Fly   775 VTAGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQS 839
            .......|....::.|:       ||||.|            :|.|           .:.::||.
Mouse   666 WPPRRRRKQLFTLQTVN-------SNGTSD------------RTTS-----------PEEMQTQP 700

  Fly   840 Y--SDWSTTIAPRYQCE---DG----EC----------SVQSCLNNFTAVELMTGQNKVGCDSCT 885
            |  .||...:..||..|   :|    :|          .::.|:..||.||.:..:|...|.||.
Mouse   701 YIAMDWEPDMKRRYYDEVEAEGYVKHDCVGYMLKKSPVQLKECIKLFTTVETLEKENPWYCSSCK 765

  Fly   886 QRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRP-----VSYP-NLLD 944
            |            :..|||:|.:...|.|||:|||||.      |.|::|.     |.:| ..||
Mouse   766 Q------------HQLATKKLDLWMLPEVLIIHLKRFS------FSKISREKLDTLVQFPIRDLD 812

  Fly   945 IAAFCGSKVKNLPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGS 1009
            .:.|. .|.||..:.|..:    |.|..|..|.|||..||||.:.     ......:|.:.
Mouse   813 FSEFV-IKPKNESSPDLYK----YDLIAVSNHYGGMRDGHYTTFA-----CNKDSGQWHYF---- 863

  Fly  1010 KAELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPL 1066
                  ||:.:..:.|...:.||.   ..:.....|.....|.:|:||   |||:|:
Mouse   864 ------DDNSVSPVNENQIESKAA---YVLFYQRQDVGRRQSQTSSSD---TPASPV 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	65/217 (30%)
		Peptidase_C19K	<849..1123	CDD:239132	66/241 (27%)
Usp11	NP_663603.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		UBP12	23..888	CDD:227847	195/812 (24%)
		DUSP	44..136	CDD:197831
		Ubiquitin_3	154..233	CDD:291502
		Peptidase_C19	<254..>370	CDD:271592	45/143 (31%)
		Peptidase_C19	258..>437	CDD:271592	65/215 (30%)
		USP7_C2	428..>541	CDD:291217	31/174 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..668		20/83 (24%)
		Peptidase_C19R	<737..887	CDD:239139	52/190 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	893..921		8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810