Protein Alignment Usp16-45 and Usp49

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_940813.1
• Gene: Usp49 / 224836
• MGIID: 2685391
• Length: 685
• Species: Mus musculus
• Alignment Length: 1130
• Identity: 199/1130 - (17%)
• Similarity: 292/1130 - (25%)
• Gaps: 557/1130 - (49%)

  Fly    45 CQHIKKAVDAARLRRLLKSTGLL----YECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFD 105
            |:|:      .|| ||.:...:|    :.|.||             ..:|.|
Mouse     4 CKHV------GRL-RLAQDHSILNPQKWCCLQC-------------ATTESA------------- 35

  Fly   106 NTLWLCLKCGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYEC-----------DMKI 159
               |.||||....|||....|||:|::   ...|.|||..|...::||.|           |:|:
Mouse    36 ---WACLKCSHVACGRYIEDHALKHFE---ETGHPLAMEVRDLYVFCYLCKDYVLNDNPEGDLKL 94

  Fly   160 CSNLRKNLLECVELVKK--LAQKPPT--ST-----VTPSTPTISYIEEKLKAALEHLTPIVPMTG 215
               ||.:|| .|...|:  ||::..|  ||     |.|...|.....:.|.|.......::..|.
Mouse    95 ---LRSSLL-AVRGQKQDLLARRGRTLRSTAAGEDVVPPQRTPQGQPQMLTALWYRRQRLLAKTL 155

  Fly   216 GSFDDSSSRGSL--------AAAGGGGGVGSSRNRQV------AIPMPPPEPSSGLSTSDSLTSV 266
            ..:...||||..        .|..........|.|:|      .:...||..|:.|     |...
Mouse   156 RLWFQKSSRGRAQLEQRRQEEALERKKEAARQRRREVKRRLLEELASAPPRKSARL-----LLHA 215

  Fly   267 PGMAKRIDQYSATTNGNTGNKRLLTLE--TPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPF 329
            ||..       |.........|.|:..  .||.:....|.|.||.||||||:.|:::|.|:....
Mouse   216 PGPV-------AVRPATLATSRRLSAAALNPRRQPAVAPGVTGLRNLGNTCYMNSILQVLSHLQK 273

  Fly   330 LLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSS-------------------WGGLT 375
            .......|.....|.:.|..|     .|..:|.....:.|:                   |.. .
Mouse   274 FRECFLNLDPSTSEHLFPQAT-----NGKAQLSGRPASSSAAELSVRSVRAQGCEPQGLCWSS-G 332

  Fly   376 AALANALEELQ------------------------AGGSVFTPRKLFDRLCVKCPQFTGGDQHDA 416
            |:::.:||.:|                        ...::.:|..:...:....|.|.|.||.||
Mouse   333 ASISRSLELIQNKEPSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDA 397

  Fly   417 HELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEE--MRQKCKIYGNQAGDRILRPEQVF 479
            .|.|.:||..|:.|         |::.|...:.:...|:.  .:|..|:...           :|
Mouse   398 QEFLCELLHKVQQE---------LESEGSTRRILIPFSQRKLTKQVLKVVNT-----------IF 442

  Fly   480 RGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTI 544
            .|.|:|.:||..|:..|:..|.|.|:||
Mouse   443 HGQLLSQVTCISCNYKSNTIEPFWDLSL------------------------------------- 470

  Fly   545 NTKFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSG 609
                                                                             
Mouse   471 ----------------------------------------------------------------- 470

  Fly   610 NGNELAESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAA 674
                                                                             
Mouse   471 ----------------------------------------------------------------- 470

  Fly   675 PSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATN 739
                                                                             
Mouse   471 ----------------------------------------------------------------- 470

  Fly   740 SSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGASNGTED 804
                                                                             
Mouse   471 ----------------------------------------------------------------- 470

  Fly   805 ADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQC-EDG-------ECSVQ 861
                    |.||                                 ||.| |.|       ||.:.
Mouse   471 --------EFPE---------------------------------RYHCIEKGFVPLNQTECLLT 494

  Fly   862 SCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQLGP 926
            ..|..||..|.:.|: ...||.|..:...|:|| ..|.:.|.|||::...|.||.||||||:...
Mouse   495 EMLAKFTETEALEGR-IYACDQCNSKRRKSNPK-PLVLSEARKQLMIYRLPQVLRLHLKRFRWSG 557

  Fly   927 RCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYGVVEHSGGMYG-GHYTAYVK 990
            |....|:...|.:..:|.:..:|...:  |.::|:  :...|.|..||.|.|..:| ||||||..
Mouse   558 RNHREKIGVHVIFDQVLTMEPYCCRDM--LSSLDK--ETFAYDLSAVVMHHGKGFGSGHYTAYCY 618

  Fly   991 VRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKE---------------KAREQHLKVL 1040
                    :....|..|.:.::||     :..:||:...:               |..|.||:
Mouse   619 --------NTEGGFWVHCNDSKLD-----VCSVEEVCKTQAYILFYTRRTVQGSAKLSEPHLQ-- 668

  Fly  1041 DDSDDFSNSSSNSSTSDESQTPATP 1065
                    :..:||:.||.:|...|
Mouse   669 --------AQVHSSSKDERRTYTLP 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464	21/61 (34%)
		UBP12	<307..990	CDD:227847	110/736 (15%)
		Peptidase_C19	307..>512	CDD:470612	55/249 (22%)
		Peptidase_C19K	<849..1123	CDD:239132	68/241 (28%)
Usp49	NP_940813.1	zf-UBP	26..87	CDD:460464	25/92 (27%)
		UCH	250..651	CDD:425685	116/783 (15%)