DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and cyk-3

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_001022992.1	Gene:	cyk-3 / 175853	WormBaseID:	WBGene00000874	Length:	1178	Species:	Caenorhabditis elegans

Alignment Length:	882	Identity:	168/882 - (19%)
Similarity:	253/882 - (28%)	Gaps:	334/882 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 PRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGT 367
            |...||.|.||.|:.||.:||||:.           .|..::.|.........:|::.    :|.
Worm   567 PGAVGLVNYGNFCYRNAGIQCLARV-----------SPLTQYFLDEDNLDAIKRGNLR----RGD 616

  Fly   368 LSSWGGLTAALANALEELQAGGSV-FTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNED 431
            .:.   .|...|..|.|:.|.... ..|....|.:.:....|...:|||..|.:..||:.:....
Worm   617 AAE---TTIEYAKLLREMWAAKKKNIAPNDFNDAIRLSSDMFECSEQHDCQEFVAFLLDQLHTSM 678

  Fly   432 LKRYQRV--------------ILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQVFRGF 482
            .:..:.:              :..:...|:.|.....||..::......:..:.::  .|:|.|.
Worm   679 YESNKSLHPSPEESEGTDSNKLSDSSKKKEADKEEADEEKAERSWTEYEKQNESLV--TQLFTGQ 741

  Fly   483 LVSTLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTK 547
            |.|.|.|:.|.:.||..|.|..:|||:..|.....|                         :...
Worm   742 LRSRLICRTCQSSSSVFEPFTSLSLPIGFEDVDLYQ-------------------------VIVV 781

  Fly   548 FTDGSV----NFTASSPSFFLHAHE--AASLGPSKSQVKKEKERQRKAKRAAKKRQKSS-----L 601
            ..||.:    .|..|..|...:..|  |.|.|.|.|.:..:....:....:.....:||     |
Worm   782 HRDGRIPRRYGFRLSRDSKVGNLREVVAVSSGISMSHLTIQCMSSKGTLMSRSPNHRSSNLRDEL 846

  Fly   602 NLNGNDSG---NGNELAESVDQDDASLAS------------LG--AGDGQANDGLEQTNGQTEDS 649
            .|:...||   ...||.||..:|...:|.            ||  ||...:..||....|..|:.
Worm   847 PLSSFPSGARLYALELPESTGEDQWRVAMHRKLQYNHEPYILGSTAGFIVSRFGLPLIVGLDEEV 911

  Fly   650 TTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEH 714
            |..              .|.||........:..|..|          |:..|..|.|
Worm   912 TGK--------------KLYEDVMYQMHRFMEHSVNS----------SSSRAHDPCE-------- 944

  Fly   715 MDKDS------LEEDENDSGIATSPA-------PTATNSSTSTSATGNNNSVAGSGLSGSSGALE 766
             |::|      ...|.|.......||       |...:.|......  |..:|...|
Worm   945 -DENSGYPFTLCLVDPNYEWCGQCPALRFCRGCPIRPDESKVFIPA--NCPIAVDWL-------- 998

  Fly   767 DPLAPASLVTAGLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQAR 831
             |:|               :..:.:...||..                 |..||.|:.
Worm   999 -PIA---------------LYLRYNHSQEQAC-----------------EDDPSVAET------- 1023

  Fly   832 TKRVRTQSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAK 896
                       ||...||        .|::.|:..|:..|.:..  .:.||.|.::
Worm  1024 -----------WSRHFAP--------SSLEHCIEKFSCPETLDA--AIQCDRCEKK--------- 1058

  Fly   897 SVNTNATKQLLVSSPPAVLILHLKRFQ-LGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNL---P 957
               |...|.:.:...|..||:|||||: |..:....|..|.|::|            :|:.   |
Worm  1059 ---TMRDKVMTIWKLPKYLIIHLKRFEFLREQGRMGKCKRTVNFP------------LKHFDPAP 1108

  Fly   958 NIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKK 1022
            .:|:.... .|....:..|.|.:..||:.||.|
Worm  1109 FVDKPDGN-TYECIALANHYGQLSCGHFIAYAK-------------------------------- 1140

  Fly  1023 LEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAA 1087
                                             |:|.
Worm  1141 ---------------------------------SNED---------------------------- 1144

  Fly  1088 NVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                   ||..::|..|:||||:...|..||||||||
Worm  1145 -------KWLLLNDCSVREVSEEEVDKQGAYLLFYER 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	49/219 (22%)
		Peptidase_C19K	<849..1123	CDD:239132	50/277 (18%)
cyk-3	NP_001022992.1	EFh_PEF	23..201	CDD:330173
		EF-hand_7	177..241	CDD:316058
		Peptidase_C19	322..1175	CDD:321984	168/882 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910