DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp15

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	NP_081880.2	Gene:	Usp15 / 14479	MGIID:	101857	Length:	981	Species:	Mus musculus

Alignment Length:	1064	Identity:	218/1064 - (20%)
Similarity:	356/1064 - (33%)	Gaps:	355/1064 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 YECDMKICSNLRKNLLECVELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGS 217
            |..::|:|.|...|.:    :.::.::.....|:......|..|.::.:|.|.:     .....:
Mouse   132 YLTELKLCENGNMNNV----VTRRFSKADTIDTIEKEIRKIFNIPDEKEARLWN-----KYMSNT 187

  Fly   218 FDDSSSRGS-LAAAG---GGGGVGSSRNRQVAIPMPPPEPSS-GLSTSDSLTSVPGMAKRIDQYS 277
            |:..:...| :..||   |...|...:|.....|..|..|.| |.|...:|..: ..:...:.|:
Mouse   188 FEPLNKPDSTIQDAGLYQGQVLVIEQKNEDGTWPRGPSTPKSPGASNFSTLPKI-SPSSLSNNYN 251

  Fly   278 ATTNGNTGNK----------RLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLS 332
            ...|.|..|.          :......|...||: |.:.||:|||||||.|:.:|||:.||
Mouse   252 NINNRNVKNSNYCLPSYTAYKNYDYSEPGRNNEQ-PGLCGLSNLGNTCFMNSAIQCLSNTP---- 311

  Fly   333 VLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGG-SVFTPRK 396
                   |..|:.|       .||...|| .....|...|.:..:.|..::::.:|. |..|||.
Mouse   312 -------PLTEYFL-------NDKYQEEL-NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRA 361

  Fly   397 LFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKC 461
            ...::....|||:|..|.|..|||..||:.: :|||.|.::.....|  ||.|        .:..
Mouse   362 FKTQVGRFAPQFSGYQQQDCQELLAFLLDGL-HEDLNRIRKKPYIQL--KDAD--------GRPD 415

  Fly   462 KIYGNQAGDRILRPE-----QVFRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAVEK-------- 513
            |:...:|.:..|:..     .:|.|...|||.|.:|..:|...:.|..::||:.::|
Mouse   416 KVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKERSLEVYL 480

  Fly   514 ------PQPPQRRKPSPEL-SLTSSSSSVTPSTGQPTINTKFTDGSVNFTASSPSFFLHA-HEAA 570
                  .:|.|.:...|:: ::....::::..:|.|......||           .:.|. |...
Mouse   481 VRMDPLAKPMQYKVIVPKIGNILDLCTALSALSGVPADKMIVTD-----------IYNHRFHRIF 534

  Fly   571 SLGPSKSQVKKEKE---------RQRKAKRAA------KKRQKSSLNLNGNDSGNGNELAESVDQ 620
            ::..:.|.:.:..:         |....:...      :|.:.||...:...|..|.....::.:
Mouse   535 AVDENLSSIMERDDIYVFEININRAEDTEHVVIPVCLREKFRHSSYTHHTGSSLFGQPFLMAIPR 599

  Fly   621 DDASLASLGAGDGQANDGLEQTNGQTEDSTTSSV-----------TTSEHSDADVEDNLVEDTAA 674
            ::                       |||...:.:           |.:|.:|..:  ...||
Mouse   600 NN-----------------------TEDKLYNLLLLRMCRYVKMSTETEETDGHL--RCCED--- 636

  Fly   675 PSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATN 739
               .|:                 |||. |.|...:.:|..|:.|  |.|:..|.....|:.. .|
Mouse   637 ---QNI-----------------NGNG-PNGLHEEGSPSEMETD--EPDDESSQDQELPSEN-EN 677

  Fly   740 SSTSTSATGNNNSVAG--------SGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQ 796
            |.:..|..|:|:|..|        ..|:|..         ..|.|...:..|.:.|..:.
Mouse   678 SQSEDSVGGDNDSENGLCTEETCKGQLTGHK---------KRLFTFQFNNLGNNDINYIK----- 728

  Fly   797 GASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSY--SDWSTTIAPRY----QCED 855
                  :|.                  :..:...|..|:..:|:  .||...:..||    ..||
Mouse   729 ------DDT------------------SHIRFDDRQLRLDERSFLALDWDPDLKKRYFDENAAED 769

  Fly   856 GE--------------CSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQL 906
            .|              ..::.|:..||..|.:..::...|.:|.:            :..|||:|
Mouse   770 FEKHESVEYKPPKRPFVKLKDCIELFTTKEKLGAEDPWYCPNCKE------------HQQATKKL 822

  Fly   907 LVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYP-NLLDIAAFCGSKVKNLPNIDRKQKKLLYAL 970
            .:.|.|.||::|||||... |.:..||...|.:| :.||::.|.         |:.......|.|
Mouse   823 DLWSLPPVLVVHLKRFSYS-RYMRDKLDTLVDFPISDLDMSEFL---------INPNAGPCRYNL 877

  Fly   971 YGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKEKAREQ 1035
            ..|..|.|||.||||||:.|                       ::||
Mouse   878 IAVSNHYGGMGGGHYTAFAK-----------------------NKDD------------------ 901

  Fly  1036 HLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVRAPPGKWYYVS 1100
                                                                      |||||..
Mouse   902 ----------------------------------------------------------GKWYYFD 908

  Fly  1101 DSRVQEVSEDTALKAQAYLLFYER 1124
            ||.|...|||..:...||:|||:|
Mouse   909 DSSVSTASEDQIVSKAAYVLFYQR 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	1/5 (20%)
		Peptidase_C19	307..>512	CDD:271592	63/210 (30%)
		Peptidase_C19K	<849..1123	CDD:239132	64/292 (22%)
Usp15	NP_081880.2	Mediates interaction with SART3. /evidence=ECO:0000250\|UniProtKB:Q9Y4E8	2..223		18/99 (18%)
		UBP12	12..932	CDD:227847	217/1062 (20%)
		DUSP	24..121	CDD:197831
		Ubiquitin_3	135..222	CDD:291502	16/95 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..237		6/20 (30%)
		Peptidase_C19	290..>475	CDD:271592	64/214 (30%)
		USP7_C2	491..>597	CDD:291217	15/116 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..694		21/87 (24%)
		Peptidase_C19R	<784..931	CDD:239139	59/267 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	952..981
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900