Protein Alignment Usp16-45 and Usp2

DIOPT Version :10

• Sequence 1: NP_572220.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_446226.3
• Gene: Usp2 / 115771
• RGDID: 621073
• Length: 618
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 119/499 - (23%)
• Similarity: 175/499 - (35%)
• Gaps: 198/499 - (39%)

  Fly   161 SNLRKNLLECVELVKKLAQKP--PTSTV-TPSTPTISYIEEKLKAALEHLTPIV--PMTGGS-FD 219
            :||..:.||    .:||..||  |||.: .|.|...|.|.:     .:...|::  .:|||| ..
  Rat    37 ANLAASFLE----KEKLGFKPVSPTSFLPRPRTYGPSSILD-----CDRGRPLLRSDITGGSKRS 92

  Fly   220 DSSSRGSLAAAG----GGGG--VGSSRNRQVAIPMPPPEPS------------------SGLSTS 260
            :|.:||:...:|    ||.|  .|.:.|....:||...:..                  |.|.||
  Rat    93 ESQTRGNERPSGSGLNGGSGFPYGVTSNSLSYLPMNARDQGVTLGQKKSNSQSDLARDFSSLRTS 157

  Fly   261 DSLTSVPGMAK----RIDQYSATTNGNTG--------NKRLLTLE------------TPRIEN-- 299
            ||..:..|...    |||.      ||.|        .|.|..|:            |..:||
  Rat   158 DSYRTSDGYRASDGFRIDP------GNLGRSPMLARTRKELCALQGLYQAASRSEYLTDYLENYG 216

  Fly   300 --------------ERLPRV-------------------------------------------RG 307
                          .|:|.|                                           .|
  Rat   217 RKGSAPQVLTQAPPSRVPEVLSPTYRPSGRYTLWEKNKGQASGPSRSTSPGRDTMNSKSAQGLAG 281

  Fly   308 LTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWG 372
            |.|||||||.|:::|||:.|       :||    .::.|.  ...::|.|.        |.|:..
  Rat   282 LRNLGNTCFMNSILQCLSNT-------REL----RDYCLQ--RLYMRDLGH--------TSSAHT 325

  Fly   373 GLTAALANALEEL--QAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRY 435
            .|....|..::.:  .:...|.:|.:...::....|:|.|.:|.||.|.||.||:.:.||
  Rat   326 ALMEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNE----- 385

  Fly   436 QRVILQNLGYKDQDVNSVS----------------EEMRQKCKIYGNQAGDRILRPEQVFRGFLV 484
                          ||.|:                |:.||..:.|..:...||   ..:|.|.|.
  Rat   386 --------------VNRVAARPKPSPESLDHLPDEEKGRQMWRKYLEREDSRI---GDLFVGQLK 433

  Fly   485 STLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSL 528
            |:|||.||...|:..:.|.|:|||:|         ::..||::|
  Rat   434 SSLTCTDCGYCSTVFDPFWDLSLPIA---------KRGYPEVTL 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_572220.1	zf-UBP	108..159	CDD:460464
		UBP12	<307..990	CDD:227847	66/240 (28%)
		Peptidase_C19	307..>512	CDD:470612	63/222 (28%)
		Peptidase_C19K	<849..1123	CDD:239132
Usp2	NP_446226.3	Necessary for interaction with MDM4. /evidence=ECO:0000250|UniProtKB:O75604	1..213		48/190 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	54..112		18/62 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..274		0/27 (0%)
		UBP12	<278..>458	CDD:227847	61/222 (27%)
		Peptidase_C19R	281..610	CDD:239139	66/240 (28%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250|UniProtKB:O75604	416..516		22/65 (34%)