Protein Alignment Usp16-45 and USP19

DIOPT Version :9

• Sequence 1: NP_001284890.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: XP_005264880.1
• Gene: USP19 / 10869
• HGNCID: 12617
• Length: 1423
• Species: Homo sapiens
• Alignment Length: 1074
• Identity: 232/1074 - (21%)
• Similarity: 342/1074 - (31%)
• Gaps: 413/1074 - (38%)

  Fly   225 GSLAAAGGGGGVGSSRNRQVAIPMPP-----------PEPSSGLSTSDSL-----------TSVP 267
            |.|.|....|.||.::   ||:|..|           |.|.:|...:.::           |.:.
Human   484 GGLEAPAARGAVGGAK---VAVPTGPTPLDSTPPGGAPHPLTGQEEARAVEKDKSKARSEDTGLD 545

  Fly   268 GMAKRIDQYSATTNGNTGNKRLLTLETPR-----------------IENER-------LPRVRGL 308
            .:|.|......|....|      .|.:|:                 :|.|.       ||...||
Human   546 SVATRTPMEHVTPKPET------HLASPKPTCMVPPMPHSPVSGDSVEEEEEEEKKVCLPGFTGL 604

  Fly   309 TNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGE-EFILPGGTFTIKDKGDIELPMIKGTLSSWG 372
            .|||||||.|:|:|.|:.|..|.....:.|...| .:..|.||                    .|
Human   605 VNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGT--------------------GG 649

  Fly   373 GLTAALANALEELQAG-GSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRNEDLKRYQ 436
            .|....|..|..|..| ...|.|.||...:..|..||||..||||.|.:..||:.: :|||.|
Human   650 RLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGL-HEDLNR-- 711

  Fly   437 RVILQNLGYKDQDVNS-------VSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDCHN 494
               :||..| .:.|:|       |:||..|:.|:    ..|..:  ..:|:|...|.|.|..|..
Human   712 ---IQNKPY-TETVDSDGRPDEVVAEEAWQRHKM----RNDSFI--VDLFQGQYKSKLVCPVCAK 766

  Fly   495 VSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSL------------------TSSSSSVTPSTGQ 541
            ||...:.||.:.:|:       ||::|..|....                  .|::|.|..|..|
Human   767 VSITFDPFLYLPVPL-------PQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQ 824

  Fly   542 ------------PTINTKFTDGSVNFTASSPSFFLHAHEAASLGPS---------KSQVKKEK-- 583
                        ..|..:|           ...||.:|...::.||         .|::.||:
Human   825 SVHVKPENLRLAEVIKNRF-----------HRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVV 878

  Fly   584 --ERQRK--------AKRAAKKRQKSSLNLNGNDS-----------GNGNELAESVDQDD----- 622
              |.|::        :|.||.:|::.|     .|.           |..|:|.:.....|
Human   879 VLEVQQRPQVPSVPISKCAACQRKQQS-----EDEKLKRCTRCYRVGYCNQLCQKTHWPDHKGLC 938

  Fly   623 --------------------ASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDN 667
                                |.||.|..|..:.:..:.|...|.......|.:
Human   939 RPENIGYPFLVSVPASRLTYARLAQLLEGYARYSVSVFQPPFQPGRMALESQS------------ 991

  Fly   668 LVEDTAAPSTNNVPSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIA-- 730
                         |..|..|:..|....||..:...|.|.:..||         ..|.|:|:.
Human   992 -------------PGCTTLLSTGSLEAGDSERDPIQPPELQLVTP---------MAEGDTGLPRV 1034

  Fly   731 -----TSPAPTATNSSTSTSATGN---NNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVI 787
                 ..|.|:.:..|:...|:|.   .:..||..:|....|:.....|:..:.|...:   ..|
Human  1035 WAAPDRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHPSEAMNAHTPQ---FFI 1096

  Fly   788 RQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQ---AMAQAQARTKRVRTQSYSDWSTTIAP 849
            .::             |:....:.:|....||.:..   ::|......:|::     ::....:.
Human  1097 YKI-------------DSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQ-----EFVLVASK 1143

  Fly   850 RYQC-ED----------GECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNAT 903
            ..:| ||          |..::..|||.||..|::..:....|..|.|            :..|:
Human  1144 ELECAEDPGSAGEAARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQ------------HREAS 1196

  Fly   904 KQLLVSSPPAVLILHLKRFQLGPRCIFR------KLTRPVSYP-NLLDIAAFC-GSKVKNLPNID 960
            ||||:...|.|||:.||||.      ||      |:...|.:| ..||::.|| |.|.:.||:
Human  1197 KQLLLWRLPNVLIVQLKRFS------FRSFIWRDKINDLVEFPVRNLDLSKFCIGQKEEQLPS-- 1253

  Fly   961 RKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEE 1025
                   |.||.|:.|.|||.||||||..::     |.|:
Human  1254 -------YDLYAVINHYGGMIGGHYTACARL-----PNDR------------------------- 1281

  Fly  1026 LLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVR 1090
                                      :|..||..
Human  1282 --------------------------SSQRSDVG------------------------------- 1289

  Fly  1091 APPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                 |....||.|..|.|...:...||:|||.|
Human  1290 -----WRLFDDSTVTTVDESQVVTRYAYVLFYRR 1318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	68/213 (32%)
		Peptidase_C19K	<849..1123	CDD:239132	68/292 (23%)
USP19	XP_005264880.1	p23_like	120..202	CDD:107220
		p23_CS_SGT1_like	391..487	CDD:107223	1/2 (50%)
		USP19_linker	478..600	CDD:293210	23/124 (19%)
		Peptidase_C19	574..>707	CDD:271592	46/153 (30%)
		Peptidase_C19	603..>789	CDD:271592	71/225 (32%)
		USP7_C2	803..>862	CDD:291217	12/69 (17%)
		zf-MYND	896..938	CDD:280009	9/46 (20%)
		Peptidase_C19R	<1160..1317	CDD:239139	65/275 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810