Protein Alignment Usp16-45 and USP20

DIOPT Version :9

• Sequence 1: NP_001284890.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001008563.2
• Gene: USP20 / 10868
• HGNCID: 12619
• Length: 914
• Species: Homo sapiens
• Alignment Length: 1144
• Identity: 214/1144 - (18%)
• Similarity: 322/1144 - (28%)
• Gaps: 531/1144 - (46%)

  Fly    45 CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLW 109
            |.|:....:..:...||||.|   .|..|                 |..||           .||
Human     8 CPHLDSIGEVTKEDLLLKSKG---TCQSC-----------------GVTGP-----------NLW 41

  Fly   110 LCLK--CGSQLCGRARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKICSNLRKNLLECVE 172
            .||:  |....||.:...|:..|.|   :..|.|.:|..:|.:|||.|:.::
Human    42 ACLQVACPYVGCGESFADHSTIHAQ---AKKHNLTVNLTTFRLWCYACEKEV------------- 90

  Fly   173 LVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGS--FDDSSSRGSLAAAGGGGG 235
                                  ::|::|.|         |:.|.|  |.:..|
Human    91 ----------------------FLEQRLAA---------PLLGSSSKFSEQDS------------ 112

  Fly   236 VGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENE 300
                         |||        |..|.:||        .:....|          |:...:::
Human   113 -------------PPP--------SHPLKAVP--------IAVADEG----------ESESEDDD 138

  Fly   301 RLPR-VRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPMI 364
            ..|| :.|:.||||:|:.||.:|.|:..|           |..:|.|..|.....||
Human   139 LKPRGLTGMKNLGNSCYMNAALQALSNCP-----------PLTQFFLECGGLVRTDK-------- 184

  Fly   365 KGTLSSWGGLTAALANALEEL------QAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQL 423
                      ..||..:.::|      :...|...|..|...:.:..|.|.|..|.|..|.||.|
Human   185 ----------KPALCKSYQKLVSEVWHKKRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCL 239

  Fly   424 LESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLT 488
            ::.: :|:||......:.....:|.| :|.::|.|:         ||
Human   240 MDQL-HEELKEPVVATVALTEARDSD-SSDTDEKRE---------GD------------------ 275

  Fly   489 CQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSV 553
                                           |.||.:..|:..|||   ..|:       .||.
Human   276 -------------------------------RSPSEDEFLSCDSSS---DRGE-------GDGQ- 298

  Fly   554 NFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESV 618
                             ..|...||.:.|.....:|.||..::::..
Human   299 -----------------GRGGGSSQAETELLIPDEAGRAISEKERMK------------------ 328

  Fly   619 DQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNVPSS 683
                         |.:.:.|.::||.:..|           .||||      |||..:.::.|:
Human   329 -------------DRKFSWGQQRTNSEQVD-----------EDADV------DTAMAALDDQPA- 362

  Fly   684 TASLTAPSKTYMDSNGNAQPPGEKRDD---TPE-----HMDKDS-----LEEDENDSGIATSP-- 733
                            .||||..:...   |||     |:...|     :...|..:.:::||
Human   363 ----------------EAQPPSPRSSSPCRTPEPDNDAHLRSSSRPCSPVHHHEGHAKLSSSPPR 411

  Fly   734 ------APTATNSSTSTSATGNN-------NSVAGSGLSGSSGALEDPLA------------PAS 773
                  ||:.........:.|:.       .||......||..:|...|.            ..|
Human   412 ASPVRMAPSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLS 476

  Fly   774 LVTAGLSE--KGASVIRQVSVGAEQGASNGTEDADG-EAKAIEQPEK-----TPSQAQAMAQAQA 830
            |...|..:  |..|.|.| :|.|:.||...:..|.| .|..:|...:     |||..
Human   477 LPIPGKEDLAKLHSAIYQ-NVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWF-------- 532

  Fly   831 RTKRVRTQSYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKA 895
                        |...:           :::.||..|.|.:.:.|.|...|:.|.:..||
Human   533 ------------WGPVV-----------TLEDCLAAFFAADELKGDNMYSCERCKKLRNG----- 569

  Fly   896 KSVNTNATKQLLVSSPPAVLILHLKRFQLGPRCIFRKLTRPVSYP-NLLDIAAF----CGSKVKN 955
                   .|...|...|.:|.:|||||:......| |:...||:| ..||:..|    |.|::..
Human   570 -------VKYCKVLRLPEILCIHLKRFRHEVMYSF-KINSHVSFPLEGLDLRPFLAKECTSQITT 626

  Fly   956 LPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQL 1020
                        |.|..|:.|.|....|||.||.:
Human   627 ------------YDLLSVICHHGTAGSGHYIAYCQ------------------------------ 649

  Fly  1021 KKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEE 1085
                             .|::
Human   650 -----------------NVIN-------------------------------------------- 653

  Fly  1086 AANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                    |:||...|..|.||.|.....|:.|:|||.:
Human   654 --------GQWYEFDDQYVTEVHETVVQNAEGYVLFYRK 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	18/52 (35%)
		Peptidase_C19	307..>512	CDD:271592	42/210 (20%)
		Peptidase_C19K	<849..1123	CDD:239132	52/278 (19%)
USP20	NP_001008563.2	zf-UBP	30..90	CDD:280334	23/90 (26%)
		UCH	144..682	CDD:278850	163/875 (19%)
		Peptidase_C19	144..>291	CDD:271592	49/238 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..347		29/218 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	360..415		13/71 (18%)
		Peptidase_C19R	443..683	CDD:239139	77/395 (19%)
		DUSP	702..785	CDD:197831
		DUSP	810..895	CDD:197831

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810