Protein Alignment Usp16-45 and USP16

DIOPT Version :9

• Sequence 1: NP_001284890.1
• Gene: Usp16-45 / 31458
• FlyBaseID: FBgn0029763
• Length: 1126
• Species: Drosophila melanogaster
• Sequence 2: NP_001027582.1
• Gene: USP16 / 10600
• HGNCID: 12614
• Length: 823
• Species: Homo sapiens
• Alignment Length: 1112
• Identity: 299/1112 - (26%)
• Similarity: 430/1112 - (38%)
• Gaps: 344/1112 - (30%)

  Fly    45 CQHIKKAVDAARLRRLLKSTGLLYECSQCQKLGKTAGSAAGAGASEGAVGPGGNPVTFEFDNTLW 109
            |:||:|.::...|::.|.:.    |.:.||.. ||..........|....|           ::|
Human    24 CRHIRKGLEQGNLKKALVNV----EWNICQDC-KTDNKVKDKAEEETEEKP-----------SVW 72

  Fly   110 LCLKCGSQLCGR-ARHKHALEHYQTPHSDSHALAMNTRSFDIWCYECDMKI--CSNLRKNLLECV 171
            ||||||.|.||| ::.:|||:||.||.|:.|.|.::..::.:|||.||.::  ||:  ..|.:.|
Human    73 LCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCDNEVQYCSS--NQLGQVV 135

  Fly   172 ELVKKLAQKPPTSTVTPSTPTISYIEEKLKAALEHLTPIVPMTGGSFDDSSSRGSLAAAGGGGGV 236
            :.|:|.|     |..||.
Human   136 DYVRKQA-----SITTPK----------------------------------------------- 148

  Fly   237 GSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRIENER 301
                         |.|..:|        ::....|::::.|.... ....|..:..|.|.:.:..
Human   149 -------------PAEKDNG--------NIELENKKLEKESKNEQ-EREKKENMAKENPPMNSPC 191

  Fly   302 LPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIEL-PMIK 365
            ...|:||:|||||||||||||.|:|||.|..:|||        :...||....:..|:.| ..::
Human   192 QITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKE--------VKMSGTIVKIEPPDLALTEPLE 248

  Fly   366 GTLSSWGGLTAALANALEELQ-AGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQLLESVRN 429
            ..|...|.||.|::..|.|:| ....|.||::||.::|.|..:|.|..|.|:.||||.||:.:|.
Human   249 INLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRA 313

  Fly   430 EDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAG-----DRILRPEQVFRGFLVSTLTC 489
            |:.:|..:.||:..|   .....:.||::.|.|.|..:..     |||      |.|.|.|.:.|
Human   314 EEHQRVSKGILKAFG---NSTEKLDEELKNKVKDYEKKKSMPSFVDRI------FGGELTSMIMC 369

  Fly   490 QDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTDGSVN 554
            ..|..||..||.|||:||||                |...|...||.....:.|:..:..|....
Human   370 DQCRTVSLVHESFLDLSLPV----------------LDDQSGKKSVNDKNLKKTVEDEDQDSEEE 418

  Fly   555 FTASSPSFFLHAHEAASLGPSK---SQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAE 616
              ..:.|:.....:..| |.||   .:.||:.::|.|.:|..:|.|...|:||
Human   419 --KDNDSYIKERSDIPS-GTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLN------------ 468

  Fly   617 SVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEH---SDADVEDNLVEDTAAPSTN 678
                                                .:.|.:|   |:.:.|.:|..:.
Human   469 ------------------------------------DICTIDHPEDSEYEAEMSLQGEV------ 491

  Fly   679 NVPSSTASLT-APSKTY----MDSNGNAQPPGEKRDD--TPEHMDKDSLEEDENDSGIATSPAPT 736
            |:.|:..|.. ...|.|    .|.||.|:......|:  :.|.:|..::..| ||..:.||
Human   492 NIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNINMD-NDLEVLTS---- 551

  Fly   737 ATNSSTSTSATGNNNSVAGSGLS-GSSGALEDPLAPASLVTAGLSEKGASVIRQVSVGAEQGASN 800
                    |.|.|.|   |:.|: ||:|.::                       :|.|.:....|
Human   552 --------SPTRNLN---GAYLTEGSNGEVD-----------------------ISNGFKNLNLN 582

  Fly   801 GTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDGECSVQSCLN 865
            .....|.....|.....||.         .:...|..:.......|:|.|......|||:|.||.
Human   583 AALHPDEINIEILNDSHTPG---------TKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLY 638

  Fly   866 NFTAVELMTGQNKVGCDSCTQR-INGSDPKA------KSVNTNATKQLLVSSPPAVLILHLKRFQ 923
            .||..|.:...||:.|:.||:| .||  |||      |.|.|||.||:|:|..|.||.|||||||
Human   639 QFTRNEKLRDANKLLCEVCTRRQCNG--PKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQ 701

  Fly   924 LGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYGVVEHSGGMYGGHYTAY 988
            .....: ||:.:.:.:|.:||:|.||..|.|   |:..:..::||:|||||||||.|..||||||
Human   702 QAGFNL-RKVNKHIKFPEILDLAPFCTLKCK---NVAEENTRVLYSLYGVVEHSGTMRSGHYTAY 762

  Fly   989 VKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNS 1053
                                                   ||.:....||..|....|.
Human   763 ---------------------------------------AKARTANSHLSNLVLHGDI------- 781

  Fly  1054 STSDESQTPATPLEEQQTQQAQQPQQPQQLEEAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAY 1118
                                      ||..|..:.     |:|:::||:.||.|.....|.:|||
Human   782 --------------------------PQDFEMESK-----GQWFHISDTHVQAVPTTKVLNSQAY 815

  Fly  1119 LLFYERI 1125
            |||||||
Human   816 LLFYERI 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334	26/51 (51%)
		Peptidase_C19	307..>512	CDD:271592	83/211 (39%)
		Peptidase_C19K	<849..1123	CDD:239132	92/280 (33%)
USP16	NP_001027582.1	zf-UBP	48..123	CDD:280334	32/86 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..189		10/111 (9%)
		Peptidase_C19K	197..>402	CDD:239132	87/237 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..460		15/68 (22%)
		Peptidase_C19K	<623..820	CDD:239132	92/279 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2096
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2092
Isobase	1	0.950	-	0	Normalized mean entropy	S5928
OMA	1	1.010	-	-		QHG47475
OrthoDB	1	1.010	-	-		D278083at2759
OrthoFinder	1	1.000	-	-		FOG0002415
OrthoInspector	1	1.000	-	-		otm41473
orthoMCL	1	0.900	-	-		OOG6_103128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2117
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.690