DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and usp43b

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_001920291.2	Gene:	usp43b / 100149276	ZFINID:	ZDB-GENE-120524-2	Length:	1183	Species:	Danio rerio

Alignment Length:	1040	Identity:	216/1040 - (20%)
Similarity:	339/1040 - (32%)	Gaps:	367/1040 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 SRGSLAAAG----------GGGGVGSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYS 277
            |.||||:.|          ..||.|.|          .|...:.:...||.||    :.::.:.|
Zfish    42 SLGSLASGGETAERSDAEDDDGGFGES----------APCAGNSVKKEDSSTS----SSQVRKSS 92

  Fly   278 ATTNGNTGNKRLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVL------KE 336
            :.|:.::..:|:.:|     ..::.|.|.||.|.|||||.|||:|||:.|..|...|      ::
Zfish    93 SLTSRSSAKERMFSL-----YGDKTPGVLGLKNHGNTCFMNAVVQCLSNTDLLAEYLGLERYKRD 152

  Fly   337 LSEPGEEFILPGGTFTIKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGGSVFTPRKLFD-R 400
            :...|....:..|... .:||::...:            |.|..||...|     :||:...: :
Zfish   153 VCHNGINGFIRNGNGQ-NEKGEVTERL------------AVLVRALWTFQ-----YTPQLSAEFK 199

  Fly   401 LCVK--CPQFTGGDQHDAHELLRQLLESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKI 463
            :.|.  ..||.|..||||.|.|..||:.:..:...     ::.|    ..::|        |.|.
Zfish   200 MTVSKYGAQFRGNSQHDALEFLLWLLDRLHEDSTS-----VVPN----GNNIN--------KSKN 247

  Fly   464 YGNQAGDR-----ILRPEQV------------FRGFLVSTLTCQDCHNVSSRHEYFLDMSLPVAV 511
            .|.:.||.     .|.|.|.            |:....|:|||..|...|:..:.||.:|||:.:
Zfish   248 KGQEGGDEKPGSDTLSPPQTQPGVRHSFVQEHFQAQYKSSLTCPHCLKQSNTFDPFLCISLPIPL 312

  Fly   512 EKPQPP----------------------------QRRKPSPELSLTSSSSSVTP--STGQPTINT 546
            .:.:|.                            .||..:.|..:......:|.  :||   ...
Zfish   313 RQTRPVCVTLVFSSKGQRYLRVGLAVPLFGSLACLRRMVADEGKIAPDQVILTEIYTTG---FQR 374

  Fly   547 KFTDGSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGND-SGN 610
            .|.|.. :.|..:.|..::|.:|:.|     .::....|......:......||....|:. :.:
Zfish   375 SFFDDD-DLTIIAESDIIYAFQASPL-----YIRGGSARISGFHHSLPSSPYSSSGPEGHRLAAS 433

  Fly   611 GNELAESVDQDDASLASL-------GAGDGQANDG----LEQTNGQTEDSTTSSVTTSEH----- 659
            |...:|.::|.|..|..|       |||......|    :.:....:.|....|:.:..:
Zfish   434 GALSSEFLNQTDGMLKVLLLVCNAAGAGQQAVRFGPPFLMREDRSVSWDQLQQSILSKLYYLMIN 498

  Fly   660 -SDAD-----VEDNLVEDTAAPSTNNVPSSTASLTAPS-KTYMDSNGNAQPPGEKRDDTPEHMDK 717
             |.|.     .:..:|..:|:.|..| |.....|..|: ...:...|:..||..|.....||..|
Zfish   499 GSQAHNFRVLFKIRVVGGSASYSYLN-PQDGRPLFHPAVDRALKLCGSGGPPHVKLIVEWEHRIK 562

  Fly   718 DSL-----EEDENDSGIATSPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTA 777
            |.|     ||...||
Zfish   563 DCLFGNIQEEVVKDS-------------------------------------------------- 577

  Fly   778 GLSEKGASVIRQVSVGAEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSD 842
                        .||.|:|
Zfish   578 ------------ESVRAQQ---------------------------------------------- 584

  Fly   843 WSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLL 907
                   ::..:...|::..|...:|..|.:...:...|..|.|...|            |.|:.
Zfish   585 -------QHHVQQHSCTLDECFELYTKEEQLAPDDAWKCPHCKQLQQG------------TVQMS 630

  Fly   908 VSSPPAVLILHLKRF-QLGPRCIFRKLTRPVSYP-NLLDIA------AFC-------GSKVKNLP 957
            :.:.|.:|||||||| |:|.|  ..||:..|.:| ..||:.      ..|       ..:....|
Zfish   631 LWTLPDILILHLKRFRQVGER--RNKLSTLVHFPLTGLDMGRHMVQRTSCARAPPGWNKQAHRRP 693

  Fly   958 NIDRKQKKLLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKK 1022
            ...|....:||.||.|..|.|||:|||||||  .|..|   |.:|          ...||..::.
Zfish   694 EASRYATDVLYDLYAVCNHHGGMHGGHYTAY--CRNSV---DGQW----------YTYDDSSVEP 743

  Fly  1023 LEE---------LL-------------------AKEKAREQHLKV-LDDSDDFSNSS---SNSST 1055
            |:|         :|                   :...:...|..: |:..:..|||:   ||||:
Zfish   744 LQEGEVCTRAAYILFYQRRDAIPSWSASCSRQGSSSSSLSDHWLIRLNADEGISNSTSKVSNSSS 808

  Fly  1056 SDESQTPATPL------EEQQTQQAQQP-----------QQPQQLEEAANVRAPPGKWYYVSDSR 1103
            :.|.|||.:|:      |:.:......|           .:.|...:..:.:..|.:|.:.|..|
Zfish   809 APEPQTPHSPVIHKSANEDNRDVAEATPFVRSVRGQSMSMRYQSKSKTGSGKVLPLRWSFASKER 873

Fly 1104 1103
Zfish 874 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	62/230 (27%)
		Peptidase_C19K	<849..1123	CDD:239132	77/319 (24%)
usp43b	XP_001920291.2	Peptidase_C19	<113..>242	CDD:271592	43/155 (28%)
		Peptidase_C19	117..>322	CDD:271592	63/239 (26%)
		Peptidase_C19R	<593..760	CDD:239139	56/195 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900