DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp16-45 and Usp43

DIOPT Version :9

Sequence 1:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster
Sequence 2:	XP_038940907.1	Gene:	Usp43 / 100147704	RGDID:	2303824	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	961	Identity:	191/961 - (19%)
Similarity:	288/961 - (29%)	Gaps:	366/961 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 GSSRNRQVAIPMPPPEPSSGLSTSDSLTSVPGMAKRIDQYSATTNGNTGNKRLLTLETPRI---E 298
            |.|..|..|.|.|......|     .....||.|       ..::|:.|..|.|..: |:|   :
  Rat    42 GDSPPRAPAQPSPYDGDGEG-----GFACAPGPA-------PASSGSPGPDRPLGSQ-PQISSGD 93

  Fly   299 NERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFTIKDKGDIELPM 363
            ..|.|..:||.|.|||||.|||:|||:.|..|           .||:..|....:..:.::...:
  Rat    94 GARPPGAQGLKNHGNTCFMNAVVQCLSNTDLL-----------AEFLALGRYRAVPGRAEVTEQL 147

  Fly   364 IKGTLSSW-----GGLTAALANALEELQAGGSVFTPRKLFDRLCVKCPQFTGGDQHDAHELLRQL 423
            .....:.|     ..|:|...||:.:.   ||                ||.|..||||.|.|..|
  Rat   148 AALVRALWTREYTPQLSAEFKNAVSKY---GS----------------QFQGNSQHDALEFLLWL 193

  Fly   424 LESVRNEDLKRYQRVILQNLGYKDQDVNSVSEEMRQKCKIYGNQAGDRILRPEQV---FRGFLVS 485
            |:.| :|||:.....  |.......:.:.:||::|       :.|....|.|..|   |:....|
  Rat   194 LDRV-HEDLEGSTHG--QGSEQLPPEASKISEDLR-------SSAAPPSLGPSFVQSHFQAQYRS 248

  Fly   486 TLTCQDCHNVSSRHEYFLDMSLPVAVEKPQPPQRRKPSPELSLTSSSSSVTPSTGQPTINTKFTD 550
            :|||..|...|:..:.||.:|||:                                |...|:|..
  Rat   249 SLTCPHCLKQSNTFDPFLCVSLPI--------------------------------PLRQTRFLS 281

  Fly   551 GSVNFTASSPSFFLHAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELA 615
            .::.|.:.|.. ||....|..:..:.:.::|                     :...:.|
  Rat   282 VTLVFPSKSQR-FLRVGLAVPILSTVAALRK---------------------MVAEEGG------ 318

  Fly   616 ESVDQDDASLASLGAGDGQANDGLEQTNGQTEDSTTSSVTTSEHSDADVEDNLVEDTAAPSTNNV 680
              |..::..|..|            ..||            .:.|..|.||   .:|.|...|..
  Rat   319 --VPAEEVILVEL------------YPNG------------FQRSFFDEED---LNTIAEGDNVY 354

  Fly   681 PSSTASLTAPSKTYMDSNGNAQPPGEKRDDTPEHMDKDSLEEDENDSGIATSPAPTATNSSTSTS 745
            ......|..|...      .|.||                       |::.||.....:|...:.
  Rat   355 AFQVPPLPGPGTL------AAHPP-----------------------GLSVSPRLAVRDSQRFSV 390

  Fly   746 ATGNNNSV-------AGSGLSGSSGA-----LED-PLAPASLVTAGLSEKGASVIRQVS------ 791
            ...:.|.|       .|||...|...     .|| .::.|.|....||:....:..:||
  Rat   391 PLHSENRVLILFCNLVGSGQQASRFGPPFLIREDRTISWAQLQQCILSKVRCLMRNEVSAQDLGT 455

  Fly   792 ------VGAEQGASN-GTED-------ADGEAKAIEQPEKTPSQAQAMAQAQARTKR----VRTQ 838
                  ||.....|. ..:|       |...|..:.:|...|....|:....:.|:|    ::.:
  Rat   456 LFSIRVVGLSLACSYLSPQDSRPLCHWAVDRALHLRRPGGPPHVKLAVEWDSSVTERLFGSLQEE 520

  Fly   839 SYSDWSTTIAPRYQCEDGECSVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNAT 903
            ...|..:....:...:...|::..|..::|..|.:...:...|..|            .|.....
  Rat   521 RVQDADSVWRQQQAHQQPSCTLDECFQSYTKEEQLAQDDAWKCPHC------------QVLQQGV 573

  Fly   904 KQLLVSSPPAVLILHLKRF-QLGPRCIFRKLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKK-- 965
            .:|.:.:.|.:||:||||| |:|.|  ..||:..|.:|.         |.:...|::.|:...
  Rat   574 VKLSLWTLPDILIIHLKRFCQVGER--RNKLSTLVKFPL---------SGLNMAPHVARRSTNSK 627

  Fly   966 ----------------------LLYALYGVVEHSGGMYGGHYTAYVKVRPKVAPGDKRWKFLPHG 1008
                                  .||.||.|..|.|.:.|||||||.:
  Rat   628 AGPGPWSSWKQPICLPTTYPLDFLYDLYAVCNHHGSLQGGHYTAYCR------------------ 674

  Fly  1009 SKAELDQDDDQLKKLEELLAKEKAREQHLKVLDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQ 1073
                                                   ||..
  Rat   675 ---------------------------------------NSLD---------------------- 678

  Fly  1074 AQQPQQPQQLEEAANVRAPPGKWYYVSDSRVQEVSEDTALKAQAYLLFYER 1124
                                |:||...||.|:.:.||......||:|||::
  Rat   679 --------------------GQWYSYDDSTVEPLREDEVNTRGAYILFYQK 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	61/212 (29%)
		Peptidase_C19K	<849..1123	CDD:239132	54/298 (18%)
Usp43	XP_038940907.1	UBP12	<77..711	CDD:227847	180/914 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900