DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a3

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	624	Identity:	225/624 - (36%)
Similarity:	338/624 - (54%)	Gaps:	47/624 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELKGVQPSNG---SSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVW 62
            :||..|:..||   :|:...|...::.:...|.......:|..||..::||:|.|..:|.|.|||
Zfish    36 VELVLVKEQNGVQFTSSSLRNPGAHSHTHTHTHTHPSGQQRETWGKKIDFLLSVIGFAVDLANVW 100

  Fly    63 RFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGT 127
            |||:..|:|||||||:||::.:.:.|.|::|:|:.:||:..:|...:|.:.|.|.|||:.....:
Zfish   101 RFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQYNREGAAGVWKICPIFKGVGFTVILIS 165

  Fly   128 ICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANESARN 190
            :.:.|||:.::|..|:|||.||..||||.:|.:.|.  ||  |.|         ..:|.|
Zfish   166 LYVGSYYNVIIAWALFYLFSSFSGELPWIHCNNTWNSPNC--SDP---------NATLLN----- 214

  Fly   191 LSGIVANDETEKLQSSSELYFLNVV-IKEKLDISDGVGDPDWKLTLALFVAWVVIFLVIMRGVKS 254
                    :|.|...:.|.:...|: :.|...|.| :|.|.|:||..|.|..||::..:.:|||:
Zfish   215 --------DTYKTTPALEYFERGVLHVHESSGIDD-LGAPRWQLTACLAVVIVVLYFSLWKGVKT 270

  Fly   255 SGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGS 319
            |||..:..|..|||||.|||:|.|||.||.|||..:|...:..|.:..||.||..|..|||.||.
Zfish   271 SGKVVWITATMPYVVLTVLLLRGVTLPGAIDGIKAYLSVDFLRLYDAQVWIEAATQICFSLGVGF 335

  Fly   320 GPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLA--HNLQIENIRDVVRSGTG 382
            |.:|.|:|||:|.:..||||:|.:::::|||...|..||:.||.::  ||:.::.   |...|.|
Zfish   336 GVLIAFSSYNKFSNNCYRDAIITSSINSLTSFFSGFVIFSFLGYMSQKHNVALDK---VATDGPG 397

  Fly   383 LAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYWKVALT--T 445
            |.||.||:||:.... ..:::|:||.||..|||.|.:....:::|.:.|:||.....:...|  .
Zfish   398 LVFIIYPEAIATLPG-SSVWAVIFFIMLLTLGIDSAMGGMESVITGLIDEFKFLHKHRELFTLFI 461

  Fly   446 SVCGFLMGLVYVTPGGQWILTLVD-FYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRV 509
            .|..||:.|:.||.||.::.||:| |..||.::|.:.| |..||.|.||:..|.||||.|..:|.
Zfish   462 VVSTFLISLICVTNGGIYVFTLLDHFAAGTSILFGVLI-EAIGIAWFYGVDRFSDDIEEMIGQRP 525

  Fly   510 SLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYIS 574
            .||||:||.|.:|..::.:.:.|..|..|.||...|||..|.:.||.|........||:..:...
Zfish   526 GLYWRLCWKFVSPCFLLFMVVVSFATFNPPKYGSYYFPTWATMVGWCLSISSMIMVPLYAFYKFC 590

  Fly   575 RHPQGTYWKSLKASLKP-SDRWGPANPEIRR----EWVI 608
            ..| |::...|..::.| :|.......|:|:    .|::
Zfish   591 SLP-GSFCDKLAYAITPETDHHLVERGEVRQFTLHHWLV 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	194/500 (39%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	216/577 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820