Protein Alignment NAAT1 and Slc6a1

DIOPT Version :9

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_077347.1
• Gene: Slc6a1 / 79212
• RGDID: 620533
• Length: 599
• Species: Rattus norvegicus
• Alignment Length: 612
• Identity: 207/612 - (33%)
• Similarity: 331/612 - (54%)
• Gaps: 62/612 - (10%)

  Fly    20 ATNAASTEKTDA----EKPTA-------------ERTNWGNGLEFLMSCISVSVGLGNVWRFPFT 67
            |....|||.::|    :||..             :|..|....:|||||:..::|||||||||:.
  Rat     9 ADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYL 73

  Fly    68 AYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIIS 132
            ..:||||||||||.:.|...|.|::.||..:||:||.|.:.:|.:.|.|.|||...|..:..:..
  Rat    74 CGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNI 138

  Fly   133 YYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIVAN 197
            ||..:::..:|||:.||.:.|||..|.:.|.          .|...:..||.|.:  |::..|.
  Rat   139 YYIVIISWAIYYLYNSFTTTLPWKQCDNPWN----------TDRCFSNYSLVNTT--NMTSAVV- 190

  Fly   198 DETEKLQSSSELYFLNVVIKEKLDISDGVGDPD---WKLTLALFVAWVVIFLVIMRGVKSSGKAA 259
                      |.:..|:     ..::||:..|.   |.|.:.|.:|||:::..|.:||..:||..
  Rat   191 ----------EFWERNM-----HQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVV 240

  Fly   260 YFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIM 324
            ||.|.:||::|.:|..|.|||.||::||||::.|.:.:|.:..||.:|..|.|||..:|.|.:|.
  Rat   241 YFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIA 305

  Fly   325 FASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYP 389
            ..|||.|.:.:|||::||..:::.||:..|..||:|:|.:|| :...:|.||..||.||||::||
  Rat   306 LGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH-VTKRSIADVAASGPGLAFLAYP 369

  Fly   390 DAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF-KGWKYWKVALTTSVC--GFL 451
            :|:::....| |:::|||.||.:|||.|........:|.:.|:: :..:..:.....:||  .:|
  Rat   370 EAVTQLPISP-LWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYL 433

  Fly   452 MGLVYVTPGGQWILTLVDFY--GGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWR 514
            :||..:|.||.::..|.|:|  .|..::| |..||...|.|.||:..|.|:|:.|...|..::|:
  Rat   434 IGLSNITQGGIYVFKLFDYYSASGMSLLF-LVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWK 497

  Fly   515 VCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQG 579
            :|||||||:::..:|::|.|.:.|:......||:.....|||:........|.: :.|:....:|
  Rat   498 LCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGY-MAYMFLTLKG 561

  Fly   580 TYWKSLKASLKPSD-----RWGPANPE 601
            :..:.|:..::||:     ..||..|:
  Rat   562 SLKQRLQVMIQPSEDIVRPENGPEQPQ 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	182/500 (36%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/13 (38%)
		SLC6sbd_GAT1	2..599	CDD:212075	207/612 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		3/12 (25%)
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820