DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a4a

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001035061.1	Gene:	slc6a4a / 664719	ZFINID:	ZDB-GENE-060314-1	Length:	646	Species:	Danio rerio

Alignment Length:	626	Identity:	207/626 - (33%)
Similarity:	330/626 - (52%)	Gaps:	63/626 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PSNGSSNGSGNGATNAASTEKTDAEKPTA---ERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAY 69
            |..|:  |:|....|...|.:|...:.|:   .|..|...::||:|.|..:|.||||||||:..|
Zfish    60 PKEGA--GTGTDRVNTPGTFRTLVVQQTSLDPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICY 122

  Fly    70 ENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWS-VVPGFVGVGYGQAFGTICIIS- 132
            :|||||||:||:::....|.|::|:|:.:|||...|.:.||. |.|.|.|:|:     .||||:
Zfish   123 QNGGGAFLLPYLLMAVFGGVPLFYMELALGQFHRSGCISIWKHVCPIFKGIGF-----AICIIAL 182

  Fly   133 ----YYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANESARNL 191
                ||::::|..||||..||::.|||:.|.:.|.  ||.:     |:...| .||..|.|.
Zfish   183 YIAFYYNTIMAWALYYLLSSFRATLPWTTCNNRWNTPNCTH-----YLSTDL-NVSWTNNSI--- 238

  Fly   192 SGIVANDETEKLQSSSELYFLNVVIKEKLDISDG---VGDPDWKLTLALFVAWVVIFLVIMRGVK 253
                         |.:|.:::..|:  ::.:|.|   :|...|:|.|.|...:.|::..|.:|||
Zfish   239 -------------SPAEEFYVRQVL--QVHLSPGLHQLGWVSWQLALCLLFIFTVVYFSIWKGVK 288

  Fly   254 SSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVG 318
            :|||..:..|.|||:||.:||||..||.||..|::|:|:|.|.:||..|||.:|..|.||||..|
Zfish   289 TSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWKKLLTTTVWLDAAAQIFFSLGPG 353

  Fly   319 SGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVR-SGTG 382
            .|.::.|||||.|.:..|:||:|.::::.|||.|.|..||.:||.:|...| :.:..|.: :|..
Zfish   354 FGVLLAFASYNPFHNNCYKDALITSSVNCLTSFLSGFVIFTVLGYMAEMRQ-QGVETVAKDAGPS 417

  Fly   383 LAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGW----KYWKVAL 443
            |.||.|.:||:...|. ..|:::||.|:.:||:.|..|....::|.:.|:|...    :.|.|..
Zfish   418 LLFIIYAEAIANMPAA-TFFAIIFFLMIIMLGLDSTFAGLEGVITAMLDEFPHLLARRREWFVLG 481

  Fly   444 TTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRR 508
            ...|| :|..|..:|.||.:::.|.:.|.....|..:...|:..:.|.||...||:|::.|....
Zfish   482 LVCVC-YLGALSTLTYGGAFVVKLFEEYATGPAVITVVFLEVIAVSWFYGTTRFCNDVQLMLGFA 545

  Fly   509 VSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQF---PLWGL 570
            ..|:|||||....|..::.|.:..:.....:|..:..:|....:.|   :.||.:.|   |.:.:
Zfish   546 PGLFWRVCWIAICPCFLLFIIVSFLAFPPEVKLFDYLYPFWTTVLG---YCIGVSSFICVPSYMV 607

  Fly   571 WYISRHPQGTYWKSLKASLKPSDRWGPANPEIRREWVIFKN 611
            :::.. .:||:.:.|...:.|.   .|.:...:|:.::..|
Zfish   608 YHLVT-TKGTFQQRLLKGITPE---APGSSGPQRDTIVITN 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	184/508 (36%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:294310	195/572 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820