Protein Alignment NAAT1 and SLC6A11

DIOPT Version :9

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_055044.1
• Gene: SLC6A11 / 6538
• HGNCID: 11044
• Length: 632
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 214/601 - (35%)
• Similarity: 311/601 - (51%)
• Gaps: 47/601 - (7%)

  Fly     9 SNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGG 73
            |.....|..:|....|...:...:|...||.:|.|.:||::|.....:|||||||||:..|:|||
Human    21 SEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGG 85

  Fly    74 GAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIISYYSSL 137
            |||||||::.....|.|:::||..:|||||:|.:..| .|.|.|.|:||........:..||..:
Human    86 GAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIII 150

  Fly   138 LALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDET 200
            ||..::||...|.:||||:.|..||.  ||               |.....:..|.|.:...:.|
Human   151 LAWAIFYLSNCFTTELPWATCGHEWNTENC---------------VEFQKLNVSNYSHVSLQNAT 200

  Fly   201 EKLQSSSELYFLNVVIKEKLDISDG---VGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFL 262
            ..:....|        ...|.||||   :|:..|:|.|.|..||.:.:..|.:|.||:||..|..
Human   201 SPVMEFWE--------HRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVT 257

  Fly   263 ALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFAS 327
            |.|||::|.:||||.|||.||.:||.|:|.|....|.:|.||.:|..|.|||.|:..|.:....|
Human   258 ATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGS 322

  Fly   328 YNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAI 392
            ||.:::..|||.:::..|::.||.:.|..||::||.:|:...:. |.:|..||.|||||:||.|:
Human   323 YNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVP-IAEVAESGPGLAFIAYPKAV 386

  Fly   393 SKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF-----KGWKYWKVALTTSVCGFLM 452
            :.....| |::.|||.||..||:.|......::||.:.|.:     :|::...:.|..||..:.:
Human   387 TMMPLSP-LWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSVISYFL 450

  Fly   453 GLVYVTPGGQWILTLVDFY--GGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRV 515
            |||.:|.||.:|..|.|.|  .|..::|: ||||...|.||||...|.|:||.|...|.....:.
Human   451 GLVMLTEGGMYIFQLFDSYAASGMCLLFV-AIFECICIGWVYGSNRFYDNIEDMIGYRPPSLIKW 514

  Fly   516 CWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLW---GLWYISRH 576
            ||...||.:...|||:.::..:|:||:.:| :|......|||:........|||   .:|    .
Human   515 CWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALSSMLCIPLWICITVW----K 575

  Fly   577 PQGTYWKSLKASLKPS 592
            .:||..:.|:....||
Human   576 TEGTLPEKLQKLTTPS 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	190/505 (38%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		4/19 (21%)
		SLC6sbd_GAT3	49..590	CDD:212077	207/570 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820