Protein Alignment NAAT1 and SLC6A6

DIOPT Version :9

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 222/620 - (35%)
• Similarity: 327/620 - (52%)
• Gaps: 64/620 - (10%)

  Fly     6 VQPSNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYE 70
            ::||.|.|.|         :..:.:||....:|..|.:.::|::|.....||||||||||:..|:
Human   119 LKPSPGKSPG---------TRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYK 174

  Fly    71 NGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIIS-- 132
            ||||||||||.|.||..|.|:::||:|:||:||:|.:..| .:.|.|.|:||    .::.|:|
Human   175 NGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGY----ASVVIVSLL 235

  Fly   133 --YYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIV 195
              ||..:||...||||.|||.||||::|...|.               |...:.:...:|.|..:
Human   236 NVYYIVILAWATYYLFQSFQKELPWAHCNHSWN---------------TPHCMEDTMRKNKSVWI 285

  Fly   196 ANDETEKLQSSSELYFLNVVIKEKLDISDGVGDP---DWKLTLALFVAWVVIFLVIMRGVKSSGK 257
            ....|.......|.:..||     |.:|.|:..|   .|.|.|.|.:.|:|.|..|.:||:|:||
Human   286 TISSTNFTSPVIEFWERNV-----LSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGK 345

  Fly   258 AAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPI 322
            ..||.|.||:.:|.|||:|.:||.||..||.|:|.|....|.:|.||.:|..|.|||.|:..|.:
Human   346 VVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAM 410

  Fly   323 IMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFIS 387
            ....|||::.:..|||.|::..|::.||.:.|..||:|||.:|....:: |.||..||.|||||:
Human   411 TSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVD-IADVAESGPGLAFIA 474

  Fly   388 YPDAISKFQAVPQLFSVLFFFMLFVLGIGS-IVALQSTIVTIICDQF-----KGWKYWKVALTTS 446
            ||.|:: ...:|..:|:|||.||.:||:.| .|.::..|.::: |.:     ||  |.:......
Human   475 YPKAVT-MMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLV-DLYPSFLRKG--YRREIFIAF 535

  Fly   447 VC--GFLMGLVYVTPGGQWILTLVDFYGGTYVVFI-LAIFELAGIVWVYGLQNFCDDIEFMCNRR 508
            ||  .:|:||..||.||.::..|.|:|..:.|..: :|.||...|.|:||..|..|.||.|...|
Human   536 VCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYR 600

  Fly   509 VSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLLFAIGAAQFPLWGLWY 572
            ...:.:..|:..|||:.:..||:|:|...|:.|::.| :|..|...||.|........||..:..
Human   601 PGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIR 665

  Fly   573 ISRHPQGTYWKSLKASLKPSD--RWGPANPEIRRE 605
            :.: .:|.:...:|..|.|.:  ||.     :.||
Human   666 LCQ-TEGPFLVRVKYLLTPREPNRWA-----VERE 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	194/509 (38%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	210/570 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820