Protein Alignment NAAT1 and SLC6A3

DIOPT Version :9

• Sequence 1: NP_572219.1
• Gene: NAAT1 / 31457
• FlyBaseID: FBgn0029762
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 607
• Identity: 213/607 - (35%)
• Similarity: 335/607 - (55%)
• Gaps: 43/607 - (7%)

  Fly    18 NGATNAASTEKTDAEKP--TAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPY 80
            ||....:||.....:.|  ..:|..||..::||:|.|..:|.|.||||||:..|:|||||||:||
Human    38 NGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPY 102

  Fly    81 IIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIIS-----YYSSLLAL 140
            ::.:.:.|.|::|:|:.:|||..:|...:|.:.|...|||:     |:.:||     :|:.::|.
Human   103 LLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGF-----TVILISLYVGFFYNVIIAW 162

  Fly   141 TLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKL 203
            .|:|||.||.:||||.:|.:.|.  ||.::.|              .:|:.:.||:   ::|...
Human   163 ALHYLFSSFTTELPWIHCNNSWNSPNCSDAHP--------------GDSSGDSSGL---NDTFGT 210

  Fly   204 QSSSELYFLNVVIKEKLDISDGVGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYV 268
            ..::|.:...|:...:....|.:|.|.|:||..|.:..|:::..:.:|||:|||..:..|..|||
Human   211 TPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYV 275

  Fly   269 VLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDH 333
            ||..||:|.|||.||.|||..:|...:..|...:||.:|..|..|||.||.|.:|.|:|||:|.:
Human   276 VLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTN 340

  Fly   334 GIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAV 398
            ..||||::.|::::|||...|..:|:.||.:|....:. |.||.:.|.||.||.||:||:.. .:
Human   341 NCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVP-IGDVAKDGPGLIFIIYPEAIATL-PL 403

  Fly   399 PQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYWKVALTTSV--CGFLMGLVYVTPGG 461
            ...::|:||.||..|||.|.:....:::|.:.|:|:.....:...|..:  ..||:.|..||.||
Human   404 SSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGG 468

  Fly   462 QWILTLVD-FYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMM 525
            .::.||:| |..||.::|.:.| |..|:.|.||:..|.|||:.|..:|.|||||:||...:|..:
Human   469 IYVFTLLDHFAAGTSILFGVLI-EAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFL 532

  Fly   526 IIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLK 590
            :.:.:.|:||..|..|....||:.||..||::.....|..|::..:.....| |::.:.|..::.
Human   533 LFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLP-GSFREKLAYAIA 596

  Fly   591 P-SDRWGPANPEIR----REWV 607
            | .||......|:|    |.|:
Human   597 PEKDRELVDRGEVRQFTLRHWL 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	184/502 (37%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	206/579 (36%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		6/29 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820