DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a6b

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001032750.1	Gene:	slc6a6b / 569098	ZFINID:	ZDB-GENE-030131-3077	Length:	625	Species:	Danio rerio

Alignment Length:	573	Identity:	221/573 - (38%)
Similarity:	320/573 - (55%)	Gaps:	62/573 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQPSNGSSNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYE 70
            ::||.|.|.|         :..:.:||....:|..|.:.|:||:|.....||||||||||:..|:
Zfish    18 LKPSPGKSPG---------TRPEDEAEGKHPQREKWASKLDFLLSVAGGFVGLGNVWRFPYLCYK 73

  Fly    71 NGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIW-SVVPGFVGVGYGQAFGTICIIS-- 132
            ||||||||||.|.||..|.|:::||:.:|||||:|.:..| .:.|.|.|:||    .:|.|:|
Zfish    74 NGGGAFLIPYFIFLFGGGLPVFFLEVALGQFTSEGGITCWEKLCPIFTGIGY----ASIVIVSLL 134

  Fly   133 --YYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSL-ANESARNLS 192
              ||..:||..|||||..||.||||:.|.::|.  |||.       |.|....:| |..:|.|.:
Zfish   135 NIYYIVILAWGLYYLFQCFQPELPWASCNNKWNTENCVE-------DTLRRNKTLWAAANATNFT 192

  Fly   193 GIVANDETEKLQSSSELYFLNVVIKEKLDISDG---VGDPDWKLTLALFVAWVVIFLVIMRGVKS 254
            ..|           :|.:..||     |.||||   ||...|.|.|.|...||:.|..:.:||||
Zfish   193 SPV-----------TEFWERNV-----LSISDGIEEVGHVKWDLALCLLAMWVICFFCVWKGVKS 241

  Fly   255 SGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGS 319
            :||..|..|.||:|:|.|||:|.|||.||.:||.|:|.|....|.:|.||.:|..|.|||.|:..
Zfish   242 TGKVVYVTATFPFVMLIVLLVRGVTLPGAAEGIKFYLYPNVTRLGDPEVWIDAGTQIFFSYAICL 306

  Fly   320 GPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLA 384
            |.:....|||::.:..|||.:::..|::.||.:.|..||::||.:|....:: |.||..||.|||
Zfish   307 GAMTSLGSYNKYKYNCYRDCLLLGGLNSATSFVSGFAIFSVLGFMAQEQGVD-IADVAESGPGLA 370

  Fly   385 FISYPDAISKFQAVPQLFSVLFFFMLFVLGIGS-IVALQSTIVTIICDQF-----KGWKYWKVAL 443
            ||:||.|:: ...:|..:::|||.||.:||:.| .|.::..|.::: |.:     ||  |.:...
Zfish   371 FIAYPKAVT-MMPLPTFWAILFFIMLLLLGLDSQFVEVEGQITSLV-DLYPSFLRKG--YRREIF 431

  Fly   444 TTSVC--GFLMGLVYVTPGGQWILTLVDFYGGTYVVFI-LAIFELAGIVWVYGLQNFCDDIEFMC 505
            ...||  .:|:||..||.||.::..|.|:|..:.|..: :|.||...:.||||..||.|.||.|.
Zfish   432 IAIVCFVSYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECIAVAWVYGADNFYDAIEEMI 496

  Fly   506 NRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELY-FPEAANIAGWLL 557
            ..|.:.:.:..|:..||.:.:..||:|:|...|::|:::| :|:.:...||.|
Zfish   497 GYRPNPWMKWSWTVVTPFLCVGCFIFSLVKYAPLRYNKIYEYPDWSIGVGWTL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	204/512 (40%)
slc6a6b	NP_001032750.1	SLC6sbd_TauT	41..582	CDD:271398	214/541 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920