DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a1l

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_021330952.1	Gene:	slc6a1l / 568985	ZFINID:	ZDB-GENE-041210-296	Length:	578	Species:	Danio rerio

Alignment Length:	546	Identity:	185/546 - (33%)
Similarity:	301/546 - (55%)	Gaps:	45/546 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFL 86
            |:...|:.:.:.|  :|.:|....:||:||:..::|||||||||:...:||||||||||...|..
Zfish    13 NSIPVEEKENKIP--DRGSWKGKFDFLLSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFTTLVF 75

  Fly    87 IGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQS 151
            .|.|::.||..:||:||.|.:.:|.::|...|||......:..:..||..::|..|||||.|.::
Zfish    76 AGIPLFLLETALGQYTSVGGLGVWKLIPMMKGVGLAAVVLSFWLNIYYIIIIAWALYYLFSSLKA 140

  Fly   152 ELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVI 216
            ||||..|.:.|.          .|...:..||.:.:  |||..|           :|.:..|:
Zfish   141 ELPWQTCDNPWN----------TDRCFSNYSLLDTT--NLSSAV-----------TEFWERNM-- 180

  Fly   217 KEKLDISDGVGDPD---WKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAV 278
               ..:::|:.:|.   |.|...|.::|::::..|.:||:.:||..||.|.:||.:||:|..|.|
Zfish   181 ---HQLTNGLEEPGELRWPLVGTLALSWILVYFSIWKGVEWTGKVVYFSATYPYFMLFILFFRGV 242

  Fly   279 TLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVT 343
            ||.||.||:||::.|.:.:||...||.:|..|.|||..:|.|.:|...|||.|::.:|||::||.
Zfish   243 TLPGAIDGVLFYITPNFNKLLKSEVWLDAATQIFFSYGLGLGSLIALGSYNSFNNNVYRDSVIVC 307

  Fly   344 TLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFF 408
            .:::.||:..||.||:|:|.::: :....|.::..||.||||::||.|:::. .:..|:::|||.
Zfish   308 CINSCTSMFAGIVIFSIVGFMSY-ITKRPIEELAASGPGLAFLAYPQAVTQL-PMSSLWAILFFS 370

  Fly   409 MLFVLGIGSIVALQSTIVTIICDQF-----KGWKYWKVALTTSVCGFLMGLVYVTPGGQWILTLV 468
            ||.:||:.|........:|.:.|::     |..|.:  .|...:..|::|...:|.||.::..|.
Zfish   371 MLMMLGLDSQFCTVEGFITALMDEYPTVLRKRKKIF--ILIVCLVSFIIGFSNITQGGLYVFKLF 433

  Fly   469 DFY--GGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIY 531
            |:|  .|..::| |..||...|.|.||.:.|..:||.|...|...:|:.||.:|||.:.:.:|.:
Zfish   434 DYYSASGMCLLF-LVFFETISIAWFYGAEKFYKNIEEMIGYRPCGFWKQCWIYFTPTICLGVFTF 497

  Fly   532 SMVTIEPIKYSELYFPEAANIAGWLL 557
            |.:.:.|:...:..:|......|||:
Zfish   498 SAIEMTPLTLGKYVYPAWGQGVGWLM 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	175/502 (35%)
slc6a1l	XP_021330952.1	SLC5-6-like_sbd	15..558	CDD:320982	184/544 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820