DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and slc6a2

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	590	Identity:	224/590 - (37%)
Similarity:	336/590 - (56%)	Gaps:	60/590 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELKGVQPSNGS--SNGSGNGATNAASTEKTDAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRF 64
            |..|||.:|.|  ::.|....|:|:..|        .||..||..::||:|.|..:|.|.|||||
Zfish    34 EQNGVQYTNSSVVASPSSRACTSASGEE--------IERETWGKKMDFLLSVIGFAVDLANVWRF 90

  Fly    65 PFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTIC 129
            |:..|:||||||||||::.||:.|.|::|:|:.:||:..:|...:|.:.|.|.||||     |:.
Zfish    91 PYLCYKNGGGAFLIPYVLFLFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGY-----TVI 150

  Fly   130 IIS-----YYSSLLALTLYYLFVSFQSELPWSYCRDEWT--NCVNSRPQEYVDNLLTGVSLANES 187
            :|:     ||:.::|.:||||:.|..|||||.:|.:.|.  ||.                    .
Zfish   151 VIALYVGFYYNVIIAWSLYYLYASLTSELPWLHCNNPWNSPNCT--------------------E 195

  Fly   188 ARNLSGIVANDETE----KLQSSSELYFLNVVIKEKLDISDGVGD---PDWKLTLALFVAWVVIF 245
            .::::|.|..:.|.    |...::|.|...|:...:   |.|:||   |.|:||:.|.|...:::
Zfish   196 PKDINGTVLGNGTSYAKYKNTPAAEFYERGVLHSHE---SKGIGDLGLPRWELTICLVVVAFILY 257

  Fly   246 LVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQ 310
            ..:.:|||||||..|..|..||:||.|||||.:||.||.:||..:|.....:|.||.||.:|..|
Zfish   258 FSLWKGVKSSGKVVYITATMPYIVLLVLLIRGITLPGAMNGIRAYLHIDLKKLNNPQVWIDAATQ 322

  Fly   311 CFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRD 375
            .||||..|.|.:|.|:|||:|::..||||::.:|::.:||...|..||::||.:|...:: ||:|
Zfish   323 IFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCVTSFFSGFAIFSVLGYMAEQHKV-NIKD 386

  Fly   376 VVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYWK 440
            |...|.||.|:.||:|||..... ..|:::||.||..|||.|.:.....::|.:.|.||..|..:
Zfish   387 VATEGAGLVFVIYPEAISTLPGA-TFFAIVFFIMLLTLGIDSSMGGMEAVLTGLSDDFKILKRNR 450

  Fly   441 VALT--TSVCGFLMGLVYVTPGGQWILTLVDFY-GGTYVVFILAIFELAGIVWVYGLQNFCDDIE 502
            ...|  |.|..|||.|:.||.||.::|||:|.| .||.::|.: :||..|:.|.||:..|.:|||
Zfish   451 KLFTFATVVGTFLMALLCVTNGGIYVLTLLDKYAAGTSILFGV-LFEAIGVSWFYGVDRFSEDIE 514

  Fly   503 FMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQF-P 566
            .|...:..:|||:||.|.:|..::::.|.|:||...:.|.|..||..|::.||.: |:.:..| |
Zfish   515 RMMGFKPGIYWRLCWKFVSPAFLLLVVIASIVTSGRLTYDEYVFPYWADMLGWSI-ALSSMLFVP 578

  Fly   567 LWGLW 571
            .:.::
Zfish   579 FYAIY 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	199/509 (39%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	213/552 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920