DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NAAT1 and Slc6a12

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_059031.1	Gene:	Slc6a12 / 50676	RGDID:	620255	Length:	628	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	214/613 - (34%)
Similarity:	323/613 - (52%)	Gaps:	54/613 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQF 101
            :|..|.|.:||::|.....:|||||||||:..|:||||||.|||.|..|..|.|:::||:.:||:
  Rat    49 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQY 113

  Fly   102 TSQGTVKIW-SVVPGFVGVGYGQAFGTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWT-- 163
            :|||:|..| .:.|...|:|.........:..||..:||..|:|||.||..||||:.|.:.|.
  Rat   114 SSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTE 178

  Fly   164 NCV------NSRPQEYVDNLLTGVSLANESARNLSGIVANDETEKLQSSSELYFLNVVIKEKLDI 222
            :||      ::|...|.:|..:.|....|  |.:.||.:.                        |
  Rat   179 HCVDFLNYSSTRAASYSENFTSPVMEFWE--RRVLGITSG------------------------I 217

  Fly   223 SDGVGDPDWKLTLALFVAWVVIFLVIMRGVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGI 287
            .| :|...|:|.|.|.:||::.:..|.:||||:||..||.|.|||::|.:||||.|||.||..||
  Rat   218 HD-LGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGI 281

  Fly   288 LFFLEPQWGELLNPTVWKEAVVQCFFSLAVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLL 352
            :|:|:|....|.:|.||.:|..|.|||.|:..|.:....|||::.:..|||::.:..|::.||.:
  Rat   282 VFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFV 346

  Fly   353 GGITIFAILGNLAHNLQIENIRDVVRSGTGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGS 417
            .|..:|:|||.:|....:. |.:|..||.|||||::|.|:: ...:.||:|.|||.||..||:.|
  Rat   347 AGFVVFSILGFMAQEQGVP-ISEVAESGPGLAFIAFPKAVT-MMPLSQLWSCLFFLMLLFLGLDS 409

  Fly   418 IVALQSTIVTIICDQF------KGWKYWKVALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYV 476
            .......:||...|.|      :|.:...:.....|| :||||:.||.||.:|..|.|:|..:.:
  Rat   410 QFVCMECLVTASMDMFPQQLRKRGRRELLILAVAIVC-YLMGLLLVTEGGMYIFQLFDYYASSGI 473

  Fly   477 -VFILAIFELAGIVWVYGLQNFCDDIEFMCNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIK 540
             :..|::||:..|.||||...|.|::|.|...|.....::.|.|.||.:.:..|.:|:....|:|
  Rat   474 CLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLK 538

  Fly   541 YSELY-FPEAANIAGWLLFAIGAAQFPLWGLWYISRHPQGTYWKSLKASLKPSDRWGPANPEIRR 604
            |:.:| :|......||||.....|..||:.:..:.: .||::.|.|:..:.|.    |:.|:..|
  Rat   539 YNNVYIYPSWGYSIGWLLAFSSMACVPLFIIITLLK-TQGSFKKRLQRLITPD----PSLPQPGR 598

  Fly   605 EWVIFKNQKAAQRATQKDTSKLGFFWRK 632
            ...  ::..:||..:.....:....|.|
  Rat   599 RSP--QDGSSAQNCSTSPVKQELIAWEK 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	188/508 (37%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:294310	206/570 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820