DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NAAT1 and slc6a5

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001009557.1	Gene:	slc6a5 / 494450	ZFINID:	ZDB-GENE-050105-2	Length:	786	Species:	Danio rerio

Alignment Length:	613	Identity:	231/613 - (37%)
Similarity:	346/613 - (56%)	Gaps:	46/613 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GATNAASTEKT----------DAEKPTAERTNWGNGLEFLMSCISVSVGLGNVWRFPFTAYENGG 73
            |......|:.|          |.......|.||.|.|:|::|.:..:||||||||||:.|::|||
Zfish   148 GTVTGPPTDDTGRLFQDDDDDDGGDENKARGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGG 212

  Fly    74 GAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAFGTICIISYYSSLL 138
            |||||||:|:|.|.|.|::.||:.:|||.|||.|.:|..:|...|.|......::.|..||:.::
Zfish   213 GAFLIPYLIMLGLAGIPIFLLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNIIM 277

  Fly   139 ALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYV--------DNLLTGVS-----LANESARN 190
            ..||||||.|.:..|||:.|::|| |.|..:.::.:        |..:|.:.     |:.....|
Zfish   278 CWTLYYLFASLKETLPWATCKNEW-NTVECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVGN 341

  Fly   191 LSGI--VANDETEKLQSSSELYFLNVVIKEKLDISDGV---GDPDWKLTLALFVAWVVIFLVIMR 250
            ||.:  |..|....:..|.|.:..||     |.||.|:   ||..|.|...||:||::::..:.:
Zfish   342 LSKLLNVTVDNKTYVSPSEEYFKYNV-----LHISKGIEYPGDIRWPLAACLFLAWLIVYASLAK 401

  Fly   251 GVKSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSL 315
            |:|||||..||.|.||||||.:||||.|||.||..|||:|:.|:|.:|.:..|||:|..|.||||
Zfish   402 GIKSSGKVVYFTATFPYVVLVILLIRGVTLPGAGSGILYFITPKWEKLNDAKVWKDAATQIFFSL 466

  Fly   316 AVGSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSG 380
            :...|.:|..:|||:|.:..|||.:|||..::.||:..|..||:::|.:||.|::. |..|...|
Zfish   467 SAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHELKVP-IESVADEG 530

  Fly   381 TGLAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQFKGWKYWK----- 440
            .|:||:.||:|:::....| .::::||.||..||:.::.|...||||.:.|:|.  ||.:
Zfish   531 PGIAFVVYPEALTRLPLSP-FWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFP--KYLRKHKPQ 592

  Fly   441 VALTTSVCGFLMGLVYVTPGGQWILTLVDFYGGTYVVFILAIFELAGIVWVYGLQNFCDDIEFMC 505
            ..|...:..|::|...:|..|.::|.|||.:..:|.:.|:|||||.||.::||||.||:|||.|.
Zfish   593 FTLVCCLSFFVLGFPMITESGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMI 657

  Fly   506 NRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWGL 570
            ..:.:.:|||||:|.||.::..|...|:...:.:.|.:..:|..:.:.|||:........|:  :
Zfish   658 GFQPNKFWRVCWAFVTPTILTFILALSLYQWKVMTYEDYTYPNWSMVLGWLMVICSVIWIPI--M 720

  Fly   571 WYISRH-PQGTYWKSLKASLKPSDRWGP 597
            :.|..| ..|:..:.||....|...|||
Zfish   721 FAIKMHLAPGSLIERLKLVCSPQPDWGP 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	210/515 (41%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:294310	227/584 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920