DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NAAT1 and slc6a1b

DIOPT Version :9

Sequence 1:	NP_572219.1	Gene:	NAAT1 / 31457	FlyBaseID:	FBgn0029762	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001007363.1	Gene:	slc6a1b / 492490	ZFINID:	ZDB-GENE-041114-57	Length:	600	Species:	Danio rerio

Alignment Length:	608	Identity:	208/608 - (34%)
Similarity:	334/608 - (54%)	Gaps:	51/608 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELKGVQPSNGSSNGSGNGATNAASTEKT-----DAEKPTAERTNWGNGLEFLMSCISVSVGLGN 60
            |...|.:.|:|......|.|..|....||     ..:|...:|..|....:||:||:..::||||
Zfish     1 MATNGTKASDGHVLTEVNEAPTANDKPKTLVVKVQKKKELPDRETWQGKFDFLLSCVGYAIGLGN 65

  Fly    61 VWRFPFTAYENGGGAFLIPYIIVLFLIGKPMYYLEMIMGQFTSQGTVKIWSVVPGFVGVGYGQAF 125
            |||||:...:||||||||||.:.|...|.|:::||..:||:||.|.:.:|.:.|.|.|||...|.
Zfish    66 VWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVWKLAPMFKGVGLAAAV 130

  Fly   126 GTICIISYYSSLLALTLYYLFVSFQSELPWSYCRDEWTNCVNSRPQEYVDNLLTGVSLANESARN 190
            .:..:..||..::|..:|||:.||.::|||..|.:.|.          .|...:..|:||  ..|
Zfish   131 LSFWLNIYYIVIIAWAIYYLYNSFTTDLPWKSCDNPWN----------TDKCFSNYSMAN--IGN 183

  Fly   191 LSGIVANDETEKLQSSSELYFLNVVIKEKLDISDGVGDP-DWKLTLA--LFVAWVVIFLVIMRGV 252
            ::..|.           |.:..|:     ..::||:..| :.:|.||  |.:|||:::..|.:||
Zfish   184 MTSAVV-----------EFWERNM-----HQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGV 232

  Fly   253 KSSGKAAYFLALFPYVVLFVLLIRAVTLEGARDGILFFLEPQWGELLNPTVWKEAVVQCFFSLAV 317
            ..:||..||.|.:||.:||:|.||.|||.||::||||::.|::.:|....||.:|..|.|||..:
Zfish   233 GWTGKVVYFSATYPYFMLFILFIRGVTLPGAKEGILFYVTPEFSKLKESEVWLDAATQIFFSYGL 297

  Fly   318 GSGPIIMFASYNRFDHGIYRDAMIVTTLDTLTSLLGGITIFAILGNLAHNLQIENIRDVVRSGTG 382
            |.|.:|...|||.|::.:|:|::||..:::.||:..|..||:|:|.:|| :....|.||..||.|
Zfish   298 GLGSLIALGSYNPFNNNVYKDSIIVCCINSFTSMFAGFVIFSIVGFMAH-ITKRPIADVAASGPG 361

  Fly   383 LAFISYPDAISKFQAVPQLFSVLFFFMLFVLGIGSIVALQSTIVTIICDQF----KGWKYWKVAL 443
            |||::||:|:::....| |::||||.||.:|||.|........:|.:.|:|    :|.:...:|:
Zfish   362 LAFLAYPEAVTQLPISP-LWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFPRALRGRREIFIAV 425

  Fly   444 TTSVC--GFLMGLVYVTPGGQWILTLVDFY--GGTYVVFILAIFELAGIVWVYGLQNFCDDIEFM 504
               ||  .:|:||..:|.||.::..|.|:|  .|..::| |..||...|.|.||:..|..::|.|
Zfish   426 ---VCLVSYLIGLSNITQGGLYVFKLFDYYSASGMCLLF-LVFFECVSISWFYGVNKFYGNLEEM 486

  Fly   505 CNRRVSLYWRVCWSFFTPVMMIIIFIYSMVTIEPIKYSELYFPEAANIAGWLLFAIGAAQFPLWG 569
            ...:..::|::||..|||:::..:|::|.|.:.|:..:...||:.....||.:........|.:
Zfish   487 IGYKPCIWWKLCWVVFTPLIVAGVFLFSAVQMVPLTLNNYVFPKWGQGVGWCMALSSMVLIPGY- 550

  Fly   570 LWYISRHPQGTYWKSLKASLKPS 592
            :.|:....:|:|.:.|:..::|:
Zfish   551 MGYMFLTLKGSYKERLRIMIQPT 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NAAT1	NP_572219.1	SLC6sbd	40..533	CDD:271359	184/503 (37%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:294310	207/607 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820